Effect of oral L-carnitine supplementation on sleep quality in hemodialysis patients

Abstract

Background & Purpose: Poor sleep quality is common among hemodialysis patients. On the other hand, hemodialysis patients are encountered with carnitine deficiency. L-carnitine is a dietary supplement that has various metabolic functions and decreases the complications during dialysis. The purpose of this study was to determine the effect of oral L-carnitine supplementation on sleep quality in hemodialysis patients.
Materials & Methods: In this double blind randomized clinical trial, 59 qualified hemodialysis patients were gone under investigation in Imam Khomeini Hospital in Shirvan during 2013. Patients were divided into intervention and control groups by permutation blocking method. Patients in the intervention group received 500 mg of L-carnitine supplement twice a day, and the placebo group was similarly taking placebo for 12 weeks. Tools for data collection consist of demographic form and Pittsburgh Sleep Quality Index which were completed before and after the intervention. Data were analyzed with SPSS statistical software version 11.5 and using independent t-test, Mann-Whitney test, chi-square, Fisher, Wilcoxon tests, Analysis of Covariance and significance level of P0.05.
Results: Before intervention, the mean PSQI scores were 9.6±4.2 and 10.1±4.13, respectively in the drug group and the placebo group and, after the intervention, the scores were, respectively, 6.4±2/8 and 9/7±3/48 that showed significant differences in both groups, compared to baseline(P0.05). Also, The PSQI score decreased by 33% in the intervention group and by 3/9% in the control group. Based on the Pittsburgh Sleep Quality Index, the lower score demonstrates a better condition of sleep qualiy.
Conclusion: This study showed that oral L-carnitine supplementation can improve sleep quality in hemodialysis patients.
Keywords
HEMODIALYSIS; L; CARNITINE; SLEEP QUALITY

Full text

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

   

   
   
       
      
    




    
      



         
     


      
    

 



 

       




     
 
     

       
      


         
    
    
 

   
    


  

       
     


    

  

     

 
 



       

    





   
  
       
  

     


  
     
   
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
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
     
   
 


       


-
  

        


     
       
    
        

     

     
 
 -
CE-

        
       

        

  

    


   


    
 
 



 
       


     
 
 
    

      
  
 


       


       

     
 



        
.    
 
        

   

AB 
       
   .  

 

        

    


-



      
      
    





    
       

-
       
   
<P
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
   






   ±  
    ±  

     
      
      
      

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        ±
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  P).   
       
± ±   
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      
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



     
         
      
-
        
      
      
       
      -
       

 
 

     
     
     

       

CC
      
      
C

       
    
      

  

     BMI 

        
       


       
     
     . 
     
    
       
   
     
     ±
±     



        
       


      
     


       
 <P  

       
      
       




      

    
     
      

     
      
    

      



-
       




     -
      

  




      
       
.   medsab.Rec.92.24
      
 
    IRCT2014030516848N1
    
  
      


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References 1. Elder SJ, Pisoni RL, Akizawa T, Fissell R, Andreucci VE, Fukuhara S, et al. Sleep quality predicts quality
of life and mortality risk in haemodialysis patients: results from the Dialysis Outcomes and Practice Patterns
Study (DOPPS). Nephrol Dial Transplant. 2008; 23(3): 998-1004.
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Quarterly Journal of Sabzevar University of Medical Sciences, Volume 22, Number 3, July & August 2015

Effect of oral L-carnitine supplementation on sleep quality
in hemodialysis patients.
Zahra Estaji
MSc of Nursing, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Bahman Jaafari
Internist, Dialysis Unit, Imam Khomeini Hospital, Shirvan.
Mohammad Hassan Rakhshani
Assistant Professor, Department of Biostatistics, School of public health, Sabzevar University of Medical Sciences,
Sabzevar,Iran.
Maryam Hatami
Master Student of Critical Care Nursing, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Received:09/02/2015, Revised:08/03/2015, Accepted:22/04/2015
Abstract
Background & Purpose: Poor sleep quality is common among
hemodialysis patients. On the other hand, hemodialysis patients
are encountered with carnitine deficiency. L-carnitine is a dietary
supplement that has various metabolic functions and decreases
the complications during dialysis. The purpose of this study was
to determine the effect of oral L-carnitine supplementation on
sleep quality in hemodialysis patients.
Materials & Methods: In this double blind randomized clinical
trial, 59 qualified hemodialysis patients were gone under
investigation in Imam Khomeini Hospital in Shirvan during 2013.
Patients were divided into intervention and control groups by
permutation blocking method. Patients in the intervention group
received 500 mg of L-carnitine supplement twice a day, and the
placebo group was similarly taking placebo for 12 weeks. Tools
for data collection consist of demographic form and Pittsburgh
Sleep Quality Index which were completed before and after the
intervention. Data were analyzed with SPSS statistical software
version 11.5 and using independent t-test, Mann-Whitney test,
chi-square, Fisher, Wilcoxon tests, Analysis of Covariance and
significance level of P0.05.
Results: Before intervention, the mean PSQI scores were
9.6±4.2 and 10.1±4.13, respectively in the drug group and the
placebo group and, after the intervention, the scores were,
respectively, 6.4±2/8 and 9/7±3/48 that showed significant
differences in both groups, compared to baseline(P0.05). Also,
The PSQI score decreased by 33% in the intervention group and
by 3/9% in the control group. Based on the Pittsburgh Sleep
Quality Index, the lower score demonstrates a better condition of
sleep qualiy.
Conclusion: This study showed that oral L-carnitine
supplementation can improve sleep quality in hemodialysis
patients.
Keywords: Hemodialysis, L-carnitine, Sleep quality
Corresponding author:
Maryam Hatami,
Sabzevar University of Medical
Sciences. Sabzevar, Iran.
E-mail: Erfan_sahel@yahoo.com