Article

Hiperplasia tímica en una paciente con enfermedad de Graves

Sección de Endocrinología y Nutrición. Complejo Hospitalario de Burgos. Burgos. España
Endocrinología y Nutrición 02/2009; 56(2). DOI: 10.1016/S1575-0922(09)70557-1
Source: OAI

ABSTRACT

Existe una relación conocida entre hiperplasia tímica (HT) e hipertiroidismo. En la mayor parte de los casos el agrandamiento del timo es mínimo; sin embargo, de forma infrecuente se puede presentar como una masa mediastínica anterior. Es importante conocer la naturaleza benigna de la HT en este contexto y su regresión tras tratar el hipertiroidismo para evitar una intervención quirúrgica innecesaria. Presentamos el caso de una paciente con HT e hipertiroidismo por enfermedad de Graves.

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    ABSTRACT: Thymus hyperplasia and Graves' disease association is not well known and is probably not incidental. We report the case of a young woman affected with Graves' disease in which a retrosternal mass was disclosed during a neck ultrasonographic-examination and confirmed by chest CT-examination. Follow-up ultrasound survey showed a decrease in the thymic mass size. Because of various antithyroid drugs allergy, a surgical procedure was performed, during which both her thyroid and thymic mass were removed. The histopathologic examination of this mass confirmed the hyperplasic nature of the thymic bulging. Ninety-one cases of thymus hyperplasia and Graves' disease association have been reported in literature, of which 20 were histologically confirmed. Among these cases 35 showed a thymic mass regression under medical treatment alone. Accordingly, surgical procedures are most frequently unnecessary in such associations because of the thymic mass decrease incurred by antithyroid drug treatment.
    Full-text · Article · Jul 2011 · Annales d Endocrinologie