Article

Effects of low molecular weight hyaluronic acid by oral intake to beautify skin: -Placebo-controlled double-blind comparative study-

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Abstract

Objectives: To investigate the safety and efficacy of hyaluronic acid for improving skin condition, a placebo-controlled double-blind comparative study was conducted in women who were concerned about wrinkles and dryness. Methods: Twenty-eight women were allocated to one of 2 groups receiving either a hyaluronic acid-containing diet or a placebo diet 3 times daily for 8 weeks. The daily intake of hyaluronic acid was 240 mg. The efficacy endpoints included skin moisture content, skin elasticity, and wrinkle characteristics based on skin replica analysis at baseline (before intake), and 4 and 8 weeks of intake. The safety endpoints included physiological, hematological, and blood biochemical adverse events. Results: The hyaluronic acid group (compared to the placebo group) showed a tendency toward improved skin moisture, had significantly improved skin elasticity at 8 weeks of intake compared with baseline, and had significantly improved mean maximum wrinkle depth at the corner of the right eye at 4 weeks of intake. Mean wrinkle area ratio and maximum wrinkle area ratio at the corner of the left eye were significantly increased at 4 and 8 weeks of intake compared with baseline in the placebo group, but not in the hyaluronic acid group. No adverse events related to food intake were observed, suggesting that intake of hyaluronic acid is safe. Conclusions The results suggest the efficacy of a diet containing hyaluronic acid for improving skin moisture, elasticity, and wrinkles.

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... The HA group presented with a significantly decreased maximum wrinkle mean depth compared with the placebo group (p < 0.01). 14 It is not confirmed whether the anti-wrinkle effect of oral HA is different depending on its MW or amount of intake. However, it is known that the bioavailability of HA differs depending on the molecular weight. ...
... A previous randomized controlled trial (RCT) study showed ingestion of the HA of MW 38 k suppressed wrinkles significantly compared with the placebo group. 14 In a previous oral administration study using labeled HA to confirm its localization by autoradiography in rats, it is suggested that HA was decomposed to low MW by intestinal bacteria, absorbed into the body, and some of decomposed HA was migrated to the skin. 18 For this reason, the efficacy of oral HA on wrinkles could not be different depending on the MW of HA. ...
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Background Hyaluronan (HA) has critical moisturizing property and high water retention capacity especially for human skin. This study aimed to evaluate the effect of oral intake of HA. Methods The mean molecular weight (MW) of HA is 2 k and 300 k. Sixty Japanese male and female subjects aged 22–59 years who presented with crow’s feet wrinkles were randomly assigned to the HA 2 k or HA 300 k at 120 mg/day or the placebo group. The subjects were administered HA at a rate of 120 mg/day or a placebo for 12 weeks. The skin wrinkles were evaluated by image analysis of skin wrinkle replicas, and their skin condition was evaluated using a questionnaire survey. Results During the study period, the HA groups showed better level of the whole sulcus volume ratio, wrinkle area ratio, and wrinkle volume ratio than the placebo group. After 8 weeks of ingestion, the HA 300 k group showed significantly diminished wrinkles compared with the placebo group. Skin luster and suppleness significantly improved after 12 weeks in all groups compared with the baseline. Conclusion The results suggest that oral HA (both HA 2 k and HA 300 k) inhibits skin wrinkles and improves skin condition.
... Para os critérios de elegibilidade, foram considerados de inclusão, os ensaios clínicos randomizados e estudos in vivo, e de exclusão, os estudos in vitro, literatura cinzenta e relatos de caso. [16]. O terceiro estudo foi desenvolvido com 28 mulheres japonesas, com idade entre 30 e 49 anos que apresentavam rugas periorbitais na face. ...
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Introdução: No corpo humano, o conteúdo total de ácido hialurônico (AH) encontrado é de aproximadamente 15g a cada 70kg e metade encontra-se na pele mais especificamente entre a derme e epiderme. Com o passar dos anos, observa-se um declínio da sua produção endógena alterando seu volume, hidratação, sustentação e elasticidade, deixando a pele com um aspecto mais envelhecido. Objetivo: Avaliar o impacto da suplementação oral do ácido hialurônico no envelhecimento cutâneo. Material e Método: Foi realizada uma revisão bibliográfica nas principais bases de dados em saúde MEDLINE, LILACS e SCIELO, utilizando os descritores em Ciências da Saúde (DeCS): ácido hialurônico, envelhecimento cutâneo e pele, nos idiomas português e inglês, considerando os últimos 5 anos. Resultado: Foram encontrados 51 estudos, 5 foram incluídos e 46 excluídos por não atenderem os critérios de elegibilidade. Os estudos observados sugerem que a ingestão de AH via oral aumenta a hidratação e diminui as linhas de expressão, sendo um possivel tratamento na prevenção do envelhecimento da pele. Sua utilização como suplemento oral também é relativamente nova em comparação com outros nutrientes usados para a pele seca e o seu envelhecimento. Conclusão: O AH possibilitou melhora na hidratação e na elasticidade da pele. Nesta revisão, a suplementação oral de diferentes doses e pesos moleculares apresentaram benefícios na saúde da pele. Entretanto, são necessários estudos clínicos randomizados para confirmar seus efeitos e estabelecer o peso molecular ideal, bem como, a dose adequada para minimizar os sinais clínicos do envelhecimento cutâneo.
... The verum group presented with a significantly decreased maximum wrinkle mean depth (p < .01) (Watanabe, Matsui, & Kondo, 2015). ...
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