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Macro- and Microlevel of Noninvasive Examination of the Vascular System
Abstract
The problem of an adequate evaluation of the cerebral vascular system condition is inseparably connected with the evaluation of the whole hemodynamic system both at systemic and regional levels
... Such attitude toward angiology and angiotherapy may be explained by deliberate distraction from understanding of the cardiovascular pathology, as there is a large gap between the information about cardiovascular system studied at medical institutions and the real state that can be explored using current medical technologies. They just need deep understanding of these processes of adequate blood supply in the organism, which actually holds the livelihoods of all living organisms [8,[44][45][46][47][48][49][50][51][52][53][54][55]. ...
... Microcirculation was studied using the method of smart optical capillaroscopy making quantitative and qualitative analysis of the capillaroscopic images from the nail bed of the fourth finger of both hands -the projection of cortical brain areas [82] (Figure 1). Analysis of the images held with the assessment of overall blood supply shortage percent, percent of structural and functional disorders of microangioarchitectonics and percent of hydrophilic perivascular tissue by means of vascular screening technology [54,[83][84][85][86]. Recently DE-3 has increased reflecting patients with significant neurological deficits and requesting the effective treatment. ...
Review: Problems of effective correction and radical solving of cardiovascular disorders are not new. However, the statistic indexes of cardiovascular pathology are growing and they are considerably younger [1-6]; this testifies to lack of effective management strategy and tactics in fight against these diseases [7-13].
Today we can make a real estimation of achieved results: for the last 20-30 years many technologies are created for research of vascular system - USD of vessels, МRТ in angiomode; devices for correction of cardiac disorders are widely used - from numerous technologies for estimation of the heart structure to coronarography and coronarshunting; new fields of radical medicine are successfully implemented, such as cardiac surgery, angiosurgery, phlebology [14-16].
And at the same time, regardless of the most up-to-date technologies for vascular diagnostics and angiosurgery cardiovascular diseases gets top ranking regarding morbidity and death rate [6,9,17,18].
It can be explained by the fact that development and introduction in medical practice of modern vascular technologies are behind a steady tendency to progress and cardiovascular diseases strike younger people.
This dissonance testifies to insufficient knowledge and analysis at the application of new technological potential of visualization of the cardiovascular system at structural (in vitro and in vivo) and functional level - in vivo [7,9,10,12,17].
Our 20-year-old experience of research of vascular disorders and successful attempts of their correction [19] has shown that
1) There is a huge layer of unexplored hemodynamic parameters, which are important in the personalized treatment processes. However, long neglecting biomechanics in medicine [20] resulted into excessive emphasis on endothelial dysfunction and cellular metamorphosis beneficial for promoting pharmacological business. As a result, doctors are not ready to think logically with categories of circulation mechanics and applied hydro- and hemodynamics [21].
2) Physicians and medical staff don't have enough knowledge in angiology, hemodynamics, hydrodynamics, analytical angiocorrection, angiotherapy, treatment management on evidential basis. Without understanding the depth of hemodynamic laws and logics of pathological and sanogenic transformations in blood supply for organs and regional reservoirs as closed system of vascular tubes - vascular blood flow, it is impossible to perform personalized adequate treatment and predict positive outcomes [8,10].
3) There is an urgent need in development of vascular monitoring technologies based on principles of evidential medicine [2,7,8,10].
Monitoring dynamic changes in any medical process management, doctors may correct on time the decline from sanogenic blood restoration in a particular regional reservoir and logic of blood redistribution in different vascular reservoirs in a patient's body.
Keywords: Personalized treatment, Hemodynamics, Cardiovascular diseases, Angiocorrection, Hydrodynamic conflicts, Brain edema, Biomarkers, Angiomarkers, Intracranial hypertension, Vascular screening, Angiotherapy
... During 2010-2017, the methodology of USDG of major arteries and veins gradually developed into Angiomarker technology with the possibility of analysis of about 50 hemodynamic parameters that proved to be significant pathohemodynamic indicators of vascular blood flow disorders, in contrast to structural changes at the macro level [52,53,54,55,56,57,58]. ...
This monograph is devoted to a topical issue - applied angiology, the place of different diagnostic methods in the verification and objectification of vascular structural and functional disorders based on deep knowledge of authors - experts in applied hemodynamics, angiology, angiotherapy - Academician of the Ukrainian Academy of Technological Sciences, Professor, Doctor of Medical Science Ulyana Lushchyk and Professor, Doctor of Physical and Mathematical Sciences Viktor Novytsky and the team of scientists headed by them. Methods of objectification of the cardiovascular system, their advantages and limitations for certain segments of the cardiovascular system, their application in the visualization and monitoring of vascular changes at the macro- and microvascular levels are described in detail.
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