Almost two decades after the liberalization of the Tunisian economy, regional disparities have been accentuated severely and are expected to grow further. The existing gap between the coastal regions and those inland is showing high inequality in terms of levels of income, growth, unemployment, productivity and poverty. The industry in the littoral regions remains the most competitive leading the Tunisian industry, while other regions in the interior lag behind with fewer strategic competences and skills and medium or even low performance. Hence, the process of regional convergence has been broken rather than achieved. The purpose of this research is to assess and quantify the macroeconomic and microeconomic impacts of seven economic policies which aiming to reduce regional disparities in Tunisia. For that purpose, we will use a micro-macro based approach with two interconnected models: A multiregional dynamic general-equilibrium model and a micro-simulation model. The implementation of these two models has enabled a projection exercise and simulation one. The first exercise studied the future evolution of the Tunisian economy in its national and regional dimensions without any economic and / or exogenous shock reforms. The results show that the littoral-internal cleavage is expected to increase if corrective measures will not be implemented. Simulation results show that trade liberalization policy benefits more to coastal regions. However, to stimulate growth performance on behalf of inland regions, positive discrimination action policies, as public and especially private investment increase, will be necessary. Moreover, reducing the economic gap performance between the coast and the interior can be done quickly through a major technological change for regions in the interior. All scenarios in this study reject the possibility of trade-off between growth and regional poverty and thus confirm the potential for pro-poor growth.