ArticlePublisher preview available
To read the full-text of this research, you can request a copy directly from the authors.

Abstract

Behavioral economic demand analyses that quantify the relationship between the consumption of a commodity and its price have proven useful in studying the reinforcing efficacy of many commodities, including drugs of abuse. An exponential equation proposed by Hursh and Silberberg (2008) has proven useful in quantifying the dissociable components of demand intensity and demand elasticity, but is limited as an analysis technique by the inability to correctly analyze consumption values of zero. We examined an exponentiated version of this equation that retains all the beneficial features of the original Hursh and Silberberg equation, but can accommodate consumption values of zero and improves its fit to the data. In Experiment 1, we compared the modified equation with the unmodified equation under different treatments of zero values in cigarette consumption data collected online from 272 participants. We found that the unmodified equation produces different results depending on how zeros are treated, while the exponentiated version incorporates zeros into the analysis, accounts for more variance, and is better able to estimate actual unconstrained consumption as reported by participants. In Experiment 2, we simulated 1,000 datasets with demand parameters known a priori and compared the equation fits. Results indicated that the exponentiated equation was better able to replicate the true values from which the test data were simulated. We conclude that an exponentiated version of the Hursh and Silberberg equation provides better fits to the data, is able to fit all consumption values including zero, and more accurately produces true parameter values. (PsycINFO Database Record (c) 2015 APA, all rights reserved).
A Modified Exponential Behavioral Economic Demand Model to Better
Describe Consumption Data
Mikhail N. Koffarnus, Christopher T. Franck, Jeffrey S. Stein, and Warren K. Bickel
Virginia Tech
Behavioral economic demand analyses that quantify the relationship between the consumption of a
commodity and its price have proven useful in studying the reinforcing efficacy of many commodities,
including drugs of abuse. An exponential equation proposed by Hursh and Silberberg (2008) has proven
useful in quantifying the dissociable components of demand intensity and demand elasticity, but is
limited as an analysis technique by the inability to correctly analyze consumption values of zero. We
examined an exponentiated version of this equation that retains all the beneficial features of the original
Hursh and Silberberg equation, but can accommodate consumption values of zero and improves its fit to
the data. In Experiment 1, we compared the modified equation with the unmodified equation under
different treatments of zero values in cigarette consumption data collected online from 272 participants.
We found that the unmodified equation produces different results depending on how zeros are treated,
while the exponentiated version incorporates zeros into the analysis, accounts for more variance, and is
better able to estimate actual unconstrained consumption as reported by participants. In Experiment 2, we
simulated 1,000 datasets with demand parameters known a priori and compared the equation fits. Results
indicated that the exponentiated equation was better able to replicate the true values from which the test
data were simulated. We conclude that an exponentiated version of the Hursh and Silberberg equation
provides better fits to the data, is able to fit all consumption values including zero, and more accurately
produces true parameter values.
Keywords: behavioral economics, demand analysis, cigarette consumption, data simulation, exponential
demand
Behavioral economic demand analyses describe the relationship
between the price (including monetary cost and/or effort) of a com-
modity and the amount of that commodity that is consumed. Such
analyses have been successful in quantifying the reinforcing efficacy
of commodities including drugs of abuse, and have been shown to be
related to other markers of addiction (Bickel, Johnson, Koffarnus,
MacKillop, & Murphy, 2014;MacKillop & Murphy, 2007). Hursh
and Silberberg (2008) proposed a now widely used equation (Equa-
tion 6 in the source paper) to be fitted to consumption data across a
range of prices:
log10Qlog10Q0k(e⫺␣Q0C1) (1)
where Qis consumption of a given commodity at price C,Q
0
is
derived consumption as price approaches zero, is demand elas-
ticity, and kis the span of the function in log
10
units. This equation
has a number of attractive features for the analysis of behavioral
economic demand data, and has become widely used as a result. It
allows for the independent measure of demand intensity (Q
0
) and
demand elasticity () for inferential and descriptive statistics.
Generally, this equation also describes demand data well and
accounts for a high proportion of the variance of consumption data
across a variety of contexts, procedures, and species (Hursh &
Silberberg, 2008;Koffarnus, Hall, & Winger, 2012;Koffarnus,
Wilson, & Bickel, 2015;Roma, Kaminski, Spiga, Ator, & Hursh,
2010). Demand intensity is often assessed in hypothetical purchase
task data without curve fitting by asking participants their level of
consumption without cost or other constraints. Outside hypothet-
ical purchase task assessments, however, unconstrained consump-
tion data are often unavailable and must be estimated from the
available data. Demand elasticity can be assessed on a point-to-
point basis without curve fitting, but these analyses are highly
sensitive to outliers in the data and do not provide a single measure
of overall demand elasticity. Furthermore, nonlinear regression
models allow for the inclusion of all consumption data in statistical
models, accounting for within-subject variability and consistency
in any statistical conclusions that are made.
The treatment of zero consumption values is one issue that has
arisen in our own and others’ research (e.g., Galuska, Banna,
Willse, Yahyavi-Firouz-Abadi, & See, 2011;Koffarnus et al.,
2012;Koffarnus et al., 2015;MacKillop et al., 2012;Yu, Liu,
Collins, Vincent, & Epstein, 2014). Fitting Equation 1 necessitates
log-transforming consumption values, as represented by the log Q
This article was published Online First August 17, 2015.
Mikhail N. Koffarnus, Virginia Tech Carilion Research Institute, Virginia
Tech; Christopher T. Franck, Virginia Tech Carilion Research Institute, Vir-
ginia Tech and Department of Statistics, Virginia Tech; Jeffrey S. Stein and
Warren K. Bickel, Virginia Tech Carilion Research Institute, Virginia Tech.
Supported by the National Cancer Institute (Grant U19 CA15734502).
None of the authors have any real or potential conflict(s) of interest,
including financial, personal, or other relationships with organizations or
pharmaceutical/biomedical companies that may inappropriately influence
the research and interpretation of the findings.
Correspondence concerning this article should be addressed to Mikhail
N. Koffarnus, PhD, VA Tech Carilion Research Institute, 2 Riverside
Circle, Roanoke, VA 24016. E-mail: mickyk@vt.edu
This document is copyrighted by the American Psychological Association or one of its allied publishers.
This article is intended solely for the personal use of the individual user and is not to be disseminated broadly.
Experimental and Clinical Psychopharmacology © 2015 American Psychological Association
2015, Vol. 23, No. 6, 504–512 1064-1297/15/$12.00 http://dx.doi.org/10.1037/pha0000045
504
... Moreover, researchers use non-linear demand curve modeling (e.g., Hursh & Silberberg, 2008;Koffarnus et al., 2015) to derive an alpha parameter (α) that reflects the rate of change in elasticity or the change in consumption as a function of price increases. ...
... We modeled demand curves using GraphPad Prism 9 software (GraphPad Software, San Diego, California). Given that all-zero and all-same consumption would represent valid responses to some of the vignettes, we derived α using the exponentiated demand curve equation provided by Koffarnus et al. (2015) in GraphPad Prism 9 (GraphPad Software, San Diego, California). The model provides a unique advantage over the Hursh & Silberberg (2008) model, given that the former can accommodate zeroes while the latter cannot. ...
... Data points reflect mean consumption at each price. Curve reflects nonlinear demand curve model generated by Koffarnus et al. (2015) equation. Note. ...
Thesis
Full-text available
Given the expanding legal cannabis market in the US, it is important to understand how cannabis use is impacted by various contexts. Therefore, this study examined the influence of cannabis cues and cannabis use context on demand for cannabis in a sample of 79 community adults. The effects of cannabis cues on self-reported craving and demand for cannabis were explored using a 2 x 2 repeated measures ANOVA, with time (baseline 1 vs. baseline 2) and cue condition (cannabis or neutral cues) as factors. Additionally, the impact of cannabis-use context (driving and sleep) on cannabis demand was investigated using a 2 x 2 x 2 repeated measures ANOVA, with context, cue condition, and block order as factors. Results showed that exposure to cannabis cues increased self-reported craving for cannabis but did not significantly affect demand for cannabis. In the driving context, participants exhibited a significant reduction in cannabis demand, characterized by lower intensity, breakpoint, Omax, and Pmax, as well as higher α. However, the sleep context did not exert a significant effect on cannabis demand. These findings suggest that cannabis use behavior is sensitive to contingencies surrounding driving after cannabis use and that public policy may effectively influence cannabis consumption in driving contexts. Furthermore, the study highlights the need for further research to corroborate the results, understand their implications for public health and policy, and gain a deeper understanding of the influence of cannabis cues on demand prior to sleep.
... For the demand phase, daily infusions and responses were recorded. Consumption was calculated infusions earned multiplied by the dose, and demand curves were calculated according to the exponentiated demand equation (Koffarnus et al., 2015a), a simple mathematical re-expression of the exponential model of demand that does not require log transformations and thus replacements or exclusions of zero values (Hursh and Silberberg, 2008): ...
... The advantages of utilizing NLME analyses over typical ANOVAs are that it allows for independent measurement of demand intensity (Q 0 ) and demand elasticity (α) for inferential and descriptive statistics. Further, this equation describes demand data well and has been utilized across a number of species including rats and humans (Koffarnus et al., 2015a(Koffarnus et al., , 2015bMaher et al., 2021;Powell et al., 2019). Graphing was performed in Prism 10.1 (Graphpad Software, San Diego, CA). ...
Article
Full-text available
Rates of tobacco and alcohol use in women are rising, and women are more vulnerable than men to escalating tobacco and alcohol use. Many women use hormonal birth control, with the oral contraceptive pill being the most prevalent. Oral contraceptives contain both a progestin (synthetic progesterone) and a synthetic estrogen (ethinyl estradiol; EE) and are contraindicated for women over 35 years who smoke. Despite this, no studies have examined how synthetic contraceptive hormones impact this pattern of polysubstance use in females. To address this critical gap in the field, we treated ovary-intact female rats with either sesame oil (vehicle), the progestin levonorgestrel (LEVO; contained in formulations such as Alesse®), or the combination of EE+LEVO in addition to either undergoing single (nicotine or saline) or polydrug (nicotine and ethanol; EtOH) self-administration (SA) in a sequential use model. Rats preferred EtOH over water following extended EtOH drinking experience as well as after nicotine or saline SA experience, and rats undergoing only nicotine SA (water controls) consumed more nicotine as compared to rats co-using EtOH and nicotine. Importantly, this effect was occluded in groups treated with contraceptive hormones. In the sequential use group, both LEVO alone and the EE+LEVO combination occluded the ability of nicotine to decrease EtOH consumption. Interestingly, demand experiments suggest an economic substitute effect between nicotine and EtOH. Together, we show that chronic synthetic hormone exposure impacts nicotine and EtOH sequential use, demonstrating the crucial need to understand how chronic use of different contraceptive formulations alter patterns of polydrug use in women.
... These parameters were calculated for each participant using the Foster and Reed Excel tool (Foster et al., 2020). Finally, participant-level derived behavioral economic parameters of Q0 (derived intensity) and alpha (rate of change in elasticity) were produced using the exponentiated demand function of Koffarnus et al. (2015) (6), Q = Q0 * 10^(k(ê(−alpha * Q0 * C) -1)), with the zero euro price replaced with 0.01, and the span parameter (k) set to *p < 0.05; ***p < 0.0001. AUDIT, Alcohol Use Disorder Identification Test. ...
... Our Comparison between means were performed using ANOVA. Q0 and alpha represent the derived indices of demand intensity and rate of change in elasticity, respectively, produced from fits of the Koffarnus et al. (2015) exponentiated demand equation to the participant-level demand data Observed intensity represents reported consumption at zero price; breakpoint-0 is the first price at which consumption is suppressed; breakpoint-1 is the last price of non-zero consumption; observed Omax is the maximum product of price × consumption; and observed Pmax is the price at which observed Omax occurs. Group 4 displayed significantly higher demand intensity (both observed and derived) compared with group 3 suggesting a more problematic use of alcohol in group 4, as seen in other population with AUD. ...
Article
Full-text available
Background: Binge drinking (BD) among students is a frequent alcohol consumption pattern that produces adverse consequences. A widely discussed difficulty in the scientific community is defining and characterizing BD patterns. This study aimed to find homogenous drinking groups and then provide a new tool, based on a model that includes several key factors of BD, to assess the severity of BD regardless of the individual’s gender. Methods: Using the learning sample (N1 = 1,271), a K-means clustering algorithm and a partial proportional odds model (PPOM) were used to isolate drinking and behavioral key factors, create homogenous groups of drinkers, and estimate the probability of belonging to these groups. Robustness of our findings were evaluated with Two validations samples (N2 = 2,310, N3 = 120) of French university students (aged 18–25 years) were anonymously investigated via demographic and alcohol consumption questionnaires (AUDIT, AUQ, Alcohol Purchase Task for behavioral economic indices). Results: The K-means revealed four homogeneous groups, based on drinking profiles: low-risk, hazardous, binge, and high-intensity BD. The PPOM generated the probability of each participant, self-identified as either male or female, to belong to one of these groups. Our results were confirmed in two validation samples, and we observed differences between the 4 drinking groups in terms of consumption consequences and behavioral economic demand indices. Conclusion: Our model reveals a progressive severity in the drinking pattern and its consequences and may better characterize binge drinking among university student samples. This model provides a new tool for assessing the severity of binge drinking and illustrates that frequency of drinking behavior and particularly drunkenness are central features of a binge drinking model.
... The exponentiated model of demand was used (Eq. 1; Koffarnus et al., 2015). The same method was used to fit curves to both aggregated and individual data. ...
Article
This study applied behavioral economic methods to assess the effects of regulatory cost on demand for the opportunity to practice behavior analysis in Ontario using a hypothetical purchase task. The provincial government of Ontario recently passed legislation to expand the psychology regulatory body to include behavior analysts. Professional regulation has been a key longstanding priority for many professionals in the province and the Ontario Association for Behaviour Analysis (ONTABA, 2021) alike. This is an important step in public protection policy, the professionalization of the practice of applied behavior analysis (ABA), and standards of practice in the province. This study aimed to inform part of the process using an operant demand framework because fees are required to operate regulatory bodies, which implies that professionals interested in becoming regulated health professionals must pay initial and ongoing fees. Demand was analyzed using the exponentiated model of demand. Participants included 60 practitioners, who indicated they were board certified behavior analysts and Ontario residents. The findings indicated that participants’ mean Pmax value (the price at which consumption becomes elastic) was $624.65 at the aggregate level. These results may indicate Ontario behavior analysts’ perceptions of the acceptability of varying costs associated with regulation. Further, the study demonstrates the applied utility of behavioral economic methods to assess demand for commodities within behavior analysis.
... These indices were chosen for parsimony, as they are better established predictors of alcohol involvement (Martínez-Loredo et al., 2021). We also included the derived index of elasticity, α, using Koffarnus et al. (2015) exponentiated demand curve equation using a k value of 4.00, determined using a model-building approach that tested model fit across four potential k values. All data were screened through the Stein et al.'s (2015) three-criterion algorithm, with a more lenient criteria for the identification of reversals (two or more). ...
Article
Objective: Population drinking trends show clear developmental periodicity, with steep increases in harmful alcohol use from ages 18 to 22 followed by a gradual decline across the 20s, albeit with persistent problematic use in a subgroup of individuals. Cross-sectional studies implicate behavioral economic indicators of alcohol overvaluation (high alcohol demand) and lack of alternative substance-free reinforcers (high proportionate alcohol-related reinforcement) as potential predictors of change during this developmental window, but longitudinal evidence is sparse. Method: Using a sample of emerging adults (N = 497, Mage = 22.61 years, 62% female, 48.69% White, 40.44% Black), this study examined prospective, bidirectional relations between both past-week heavy drinking days (HDD) and alcohol problems and proportionate alcohol-related reinforcement (reinforcement ratio), alcohol demand intensity (consumption at zero price), alcohol demand Omax (maximum expenditure), and change in demand elasticity (rate of change in consumption across escalating price) over five assessments (every 4 months) using random intercept cross-lagged panel models. Results: Alcohol problems and HDD decreased across assessments. Significant between-person effects indicated that each behavioral economic variable was associated with increased drinking risk. Change in reinforcement ratio was positively associated with decreases in alcohol problems. Multigroup invariance modeling revealed distinct risk pathways in that change in demand intensity and Omax predicted change in alcohol problems for male participants and change in intensity predicted change in alcohol problems for non-White participants. Conclusion: The study provides consistent support for proportionate alcohol-related reinforcement and mixed support for demand as within-person predictors of reductions in drinking. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
Article
Background Behavioral economic research has revealed significant increases in alcohol demand following exposure to alcohol‐related cues. Prior research has focused exclusively on nontreatment‐seeking heavy drinkers, included only male participants, or used heterogeneous methods. The current studies sought to replicate and extend existing findings in treatment‐seeking and nontreatment‐seeking heavy drinkers while also examining sex effects and moderation by alcohol use disorder (AUD) severity. Methods Study 1 included 117 nontreatment‐seeking heavy drinkers (51.5% women; M age 34.69; 56.4% AUD+), and Study 2 included 89 treatment‐seeking heavy drinkers with AUD (40.4% women; M age = 41.35). In both studies, alcohol demand was measured using a hypothetical alcohol purchase task (APT), and subjective alcohol craving was measured using visual analog scales. Measures were collected following exposure to neutral (water) cues in a standard room and alcohol cues in a bar lab. Results Alcohol demand (intensity, O max , breakpoint, and elasticity) and craving were significantly increased following alcohol cues compared to neutral cues ( p s < 0.005) with effect sizes ranging from small to large ( η p ² = 0.074–0.480). Participants with AUD (Study 1) or with higher AUD severity (Study 2) reported higher craving and higher demand for most indices (i.e., main effects; p s < 0.032, η p ² = 0.043–0.239). A larger alcohol cue increase in O max was found for AUD+ participants in Study 1 compared to non‐AUD participants ( p = 0.028, η p ² = 0.041) but not for any other indices in Study 1 or Study 2. There were no significant sex effects. Conclusions These findings replicate and extend prior research by offering additional insight into alcohol cue effects on the reinforcing value of alcohol and subjective motivation to drink. The results also suggest that sex and AUD severity do not meaningfully impact cue effects across most indices of demand.
Article
Climate change is a threat to current and future generations. One behavior change that may produce substantial emission reductions is a shift from using personal vehicles to public transportation. While the use of public transportation allows reductions in personal emissions, it is associated with extra time spent en route. Behavioral economic studies of demand have demonstrated the effects of delay on choice, but few have addressed the effects of delay on use of transportation modalities. Additionally, studies targeting environmentally relevant commodities have occasionally examined choice when outcomes are framed as being environmentally beneficial, but this is likely not representative of naturalistic choice opportunities where framing is absent. The purpose of the current study was to demonstrate the effects of time as a cost on the hypothetical use of public transportation, and to evaluate the effects of a framing manipulation on participants’ responses. We found that participants’ reported use of public transportation was sensitive to time as a cost, that environmental framing increased reported use relative to previous neutral framing, but that the sequence of framing conditions moderated changes in responses.
Article
Background In October 2021, a legal framework that regulates cannabis for recreational purposes in Spain was proposed, but research on its potential impacts on cannabis use is currently limited. This study examined the reliability and discriminant validity of two Marijuana Purchase Tasks (MPTs) for measuring hypothetical legal and illegal cannabis demand, and to examine differences in demand of both commodities in young adults at hazardous vs. non-hazardous cannabis use risk levels. Methods A total of 171 Spanish young adults [Mage= 19.82 (SD=1.81)] with past-month cannabis use participated in a cross-sectional study from September to November 2021. Two 27-item MPTs were used to estimate hypothetical demand for legal and illegal cannabis independently. The Cannabis Use Disorder Identification Test (CUDIT-R) was used to assess hazardous cannabis use and test for discriminant validity of the MPTs. Reliability analyses were conducted using Classical Test Theory (Cronbach’s alpha) and Item Response Theory (Item Information Functions). Results The MPT was reliable for measuring legal (α=.94) and illegal (α=.90) cannabis demand. Breakpoint (price at which demand ceases), and Pmax (price associated with maximum expenditure) were the most sensitive indicators to discriminate participants with different levels of the cannabis reinforcing trait. No significant differences between legal and illegal cannabis demand in the whole sample were observed, but hazardous vs. non-hazardous users showed higher legal and illegal demand, and decreased Breakpoint and Pmax if cannabis were legal vs illegal. Conclusion The MPT exhibits robust psychometric validity and may be useful to inform on cannabis regulatory science in Spain.
Article
Behavioral economic demand for cannabis is robustly associated with cannabis consumption and cannabis use disorder (CUD). However, few studies have examined the processes underlying individual differences in the relative valuation of cannabis (i.e., demand). This study examined associations between executive functions and cannabis demand among young adults who use cannabis. We also examined indirect associations of executive functions with cannabis consumption and CUD symptoms through cannabis demand. Young adults (N = 113; 58.4% female; mean age 22 years) completed a Marijuana Purchase Task. Participants also completed cognitive tasks assessing executive functions (set shifting, inhibitory control, working memory) and semistructured interviews assessing past 90-day cannabis consumption (number of grams used) and number of CUD symptoms. Poorer inhibitory control was significantly associated with greater Omax (peak expenditure on cannabis) and greater intensity (cannabis consumption at zero cost). Poorer working memory was significantly associated with lower elasticity (sensitivity of consumption to escalating cost). Lower inhibitory control was indirectly associated with greater cannabis consumption and CUD symptoms through greater Omax and intensity, and poorer working memory was indirectly associated with greater cannabis consumption and CUD symptoms through reduced elasticity. This study provides novel evidence that executive functions are associated with individual differences in cannabis demand. Moreover, these results suggest that cannabis demand could be a mechanism linking poorer executive functioning with heavier cannabis use and CUD, which should be confirmed in future longitudinal studies.
Article
Full-text available
The field of behavioral economics has made important inroads into the understanding of substance use disorders through the concept of reinforcer pathology. Reinforcer pathology refers to the joint effects of (a) the persistently high valuation of a reinforcer, broadly defined to include tangible commodities and experiences, and/or (b) the excessive preference for the immediate acquisition or consumption of a commodity despite long-term negative outcomes. From this perspective, reinforcer pathology results from the recursive interactions of endogenous person-level variables and exogenous environment-level factors. The current review describes the basic principles of behavioral economics that are central to reinforcer pathology, the processes that engender reinforcer pathology, and the approaches and procedures that can repair reinforcement pathologies. The overall goal of this review is to present a new understanding of substance use disorders as viewed by recent advances in behavioral economics.
Article
Full-text available
The application of economics principles to the analysis of behavior has yielded novel insights on value and choice across contexts ranging from laboratory animal research to clinical populations to national trends of global impact. Recent innovations in demand curve methods provide a credible means of quantitatively comparing qualitatively different reinforcers as well as quantifying the choice relations between concurrently available reinforcers. The potential of the behavioral economic approach to inform public policy is illustrated with examples from basic research, pre-clinical behavioral pharmacology, and clinical drug abuse research as well as emerging applications to public transportation and social behavior. Behavioral Economics can serve as a broadly applicable conceptual, methodological, and analytical framework for the development and evaluation of empirical public policy.
Article
Full-text available
Introduction: Varenicline (Chantix®) is an efficacious first-line medication for smoking cessation. Studies suggest that one mechanism by which varenicline facilitates sustained smoking abstinence is by reducing the likelihood of relapse to smoking when a lapse, or slip, occurs during a quit attempt. The present study extends this line of research by conducting a prospective laboratory study to examine the relapse prevention effects of varenicline following a programmed lapse. Methods: Daily smokers (N = 47) completed a 5-week outpatient study in which they were randomized to receive varenicline or placebo. The first week was a medication induction period that was immediately followed by a 4-week quit attempt. A programmed lapse (2 cigarettes smoked in the laboratory) occurred on the second day of the quit attempt. Results: Participants receiving varenicline were slower to relapse and had greater total abstinence rates following lapse exposure. Participants in the varenicline group rated lapse cigarettes lower on measures of reward and intoxication and showed increased behavioral economic demand elasticity for cigarettes (reduced cigarette purchasing at higher prices) compared with those receiving placebo. Conclusions: These results demonstrate a relapse prevention effect of varenicline following smoking lapse exposure and suggest that an attenuation of reward from smoking and the blunting of subjective effects of smoking may underlie and/or contribute to this effect.
Article
Methods for quantifying natural and drug reward in clinical and preclinical research often yield mixed results due to procedural limitations or differences between subject populations or treatments. However, the recently introduced “exponential model of demand” may serve as a unifying behavioral methodology for assessing reward and motivation. The model is rooted in behavioral economics and involves a single “price” (fixed‐ratio requirement) per unit of reinforcement per session across several sessions of increasing price. Rather than defining reinforcement as response output or absolute consumption at any one point, the “essential value” of the reinforcer is the rate of decrease in consumption across the range of prices. This change in demand elasticity is calculated in the model as a single value for each subject that is informative yet resilient to dose, potency, concentration, and endogenous biological/genetic confounds. The novel concept of “essential value” is arguably the most sophisticated, comprehensive, and realistic laboratory model of reward and motivation to date. Retrospective and recently collected data support the model's utility. Its impact could be significant for translational behavioral pharmacology, with applications to drug abuse, medications testing, and elucidating the neural and genetic mechanisms mediating reward using a homologous methodology within and across species.
Article
Behavioral economic demand curves (Hursh, Raslear, Shurtleff, Bauman, & Simmons, 1988) are innovative approaches to characterize the relationships between consumption of a substance and its price. In this article, we investigate common analytical issues in the use of behavioral economic demand curves, which can cause inconsistent interpretations of demand curves, and then we provide methodological suggestions to address those analytical issues. We first demonstrate that log transformation with different added values for handling zeros changes model parameter estimates dramatically. Second, demand curves are often analyzed using an overparameterized model that results in an inefficient use of the available data and a lack of assessment of the variability among individuals. To address these issues, we apply a nonlinear mixed effects model based on multivariate error structures that has not been used previously to analyze behavioral economic demand curves in the literature. We also propose analytical formulas for the relevant standard errors of derived values such as P max, O max, and elasticity. The proposed model stabilizes the derived values regardless of using different added increments and provides substantially smaller standard errors. We illustrate the data analysis procedure using data from a relative reinforcement efficacy study of simulated marijuana purchasing.
Article
Introduction: Cigarette demand, or the change in cigarette consumption as a function of price, is a measure of reinforcement that is associated with level of tobacco dependence and other clinically relevant measures, but the effects of experimentally controlled income on real-world cigarette consumption have not been examined. Methods: In this study, income available for cigarette purchases was manipulated to assess the effect on cigarette demand. Tobacco-dependent cigarette smokers (n = 15) who smoked 10-40 cigarettes per day completed a series of cigarette purchasing tasks under a variety of income conditions meant to mimic different weekly cigarette budgets: $280, approximately $127, $70, or approximately $32 per week. Prices of $0.12, $0.25, $0.50, and $1.00 per cigarette were assessed in each income condition. Participants were instructed to purchase as many cigarettes as they would like for the next week and to only consume cigarettes purchased in the context of the study. One price in 1 income condition was randomly chosen to be "real," and the cigarettes and the excess money in the budget for that condition were given to the participant. Results: Results indicate that demand elasticity was negatively correlated with income. Demand intensity (consumption at low prices) was unrelated to income condition and remained high across incomes. Conclusions: These results indicate that the amount of income that is available for cigarette purchases has a large effect on cigarette consumption, but only at high prices.
Article
This paper proposes an extension of generalized linear models to the analysis of longitudinal data. We introduce a class of estimating equations that give consistent estimates of the regression parameters and of their variance under mild assumptions about the time dependence. The estimating equations are derived without specifying the joint distribution of a subject's observations yet they reduce to the score equations for niultivariate Gaussian outcomes. Asymptotic theory is presented for the general class of estimators. Specific cases in which we assume independence, m-dependence and exchangeable correlation structures from each subject are discussed. Efficiency of the pioposecl estimators in two simple situations is considered. The approach is closely related to quasi-likelihood.
Article
Aims: Novel methods in behavioral economics permit the systematic assessment of the relationship between cigarette consumption and price. Towards informing tax policy, the goals of this study were to conduct a high-resolution analysis of cigarette demand in a large sample of adult smokers and to use the data to estimate the effects of tax increases in 10 US States. Design: In-person descriptive survey assessment. Setting: Academic departments at three universities. Participants: Adult daily smokers (i.e. more than five cigarettes/day; 18+ years old; ≥8th grade education); n = 1056. Measurements: Estimated cigarette demand, demographics, expired carbon monoxide. Findings: The cigarette demand curve exhibited highly variable levels of price sensitivity, especially in the form of 'left-digit effects' (i.e. very high price sensitivity as pack prices transitioned from one whole number to the next; e.g. $5.80-6/pack). A $1 tax increase in the 10 states was projected to reduce the economic burden of smoking by an average of $530.6 million (range: $93.6-976.5 million) and increase gross tax revenue by an average of 162% (range: 114-247%). Conclusions: Tobacco price sensitivity is non-linear across the demand curve and in particular for pack-level left-digit price transitions. Tax increases in US states with similar price and tax rates to the sample are projected to result in substantial decreases in smoking-related costs and substantial increases in tax revenues.