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Histopathological and histochemical changes in the skin of Black Bengal Goats with induced sarcoptic mange infection

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Abstract

The histo-pathological changes in the skin of black Bengal breed goat experimentally infected with Sarcoptes scabiei var. caprae was studied. The sections revealed invasion of the parasites, acanthosis, hyperkeratosis and parakeratosis in the epidermal layers. Acute haemorrhagic changes and cellular infiltration were also observed. In few places, hyperplastic changes in sebaceous glands were also observed. There was increased storage of keratin and prekeratin in stratum spinosum, in comparison to the healthy control skin. Where as melanin storage in the layer of stratum malpighii was reduced in the infected skin in comparison to healthy control skin.
... Haematological findings of lowered hemoglobin and hematocrit with granulocytic leukocytosis observed in goats were in agreement with the findings of Sengupta et al. (2008) in experimentally induced mange in Black Bengal goats and Vishe et al. (2012) in Surati buffaloes and buffalo calves. The findings of anemia were also in agreement with the findings of De and Dey (2010) as well as Parmar and Chandra (2018) in goats and sheep, respectively. ...
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A flock of Osmanabadi goats (n=20) was presented to the clinics with the history of hair loss, intense pruritus, decrease in body weight and eventual mortality of four kids since last month. Clinical examination revealed tachycardia, tachypnea and pale mucosae. Marked focal to generalized alopecia was noticed over the face, ears, around eyes and neck with concurrent crusting, hyperkeratosis, thickening and folding of affected skin along with severe pruritus. In few animals, the lesions were extended over shoulder and thoraco-abdominal region, limbs and scrotum. Haematological analysis revealed marked granulocytic leukocytosis and anemia. Skin scrapping examination revealed presence of numerous Sarcoptes scabiei mites and their eggs. All the affected goats were treated with two doses of ivermectin @ 0.2 mg/kg subcutaneously at weekly intervals along with antihistaminic and multivitamin for 5 days, haematinics for 15 days. Appreciable response to the therapy was observed in treated flock by fortnight with marked resolution of clinical signs after one month of therapy in terms of regrowth of hairs, subsidence of crusting, hyperkeratosis and skin thickening accompanied with enhanced skin pliability and shine. Similarly, improved haemogram and increased weight gain in kids was observed signifying the encouraging response to the therapy.
Article
Sarcoptic mange is an extremely common contagious skin disease caused by the mite Sarcoptes scabiei and affecting all domestic animals through host-adapted variants. It impacts health, productivity and economy of livestock through high morbidity and even mortality. Reports in literature indicate widespread prevalence in practically every part of the country. The problem is more common in young animals. Clinico-pathological and haemato biochemical changes cover a wide spectrum. Diagnosis based on demonstration of mites is often difficult. Successful detection of specific antibody to S. scabiei inmange-affected dogs, pigs and in human scabies, holds promise for development of reliable serological tests. For therapy, reported success of indigenous formulations and herbals has resulted in a trend for their usage as safe, cost-effective and easily-available alternatives. Development of a vaccine for prophylaxis seems to be a distinct possibility through the application of molecular tools and improved techniques now available. In this review, reference has also been made to recent reports on salient aspects of human scabies - a common dermatologic problem whose incidence and severity are on the rise due to AIDS and use of immunosuppressants.
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Present study investigated the prevalence and hemato-biochemical changes observed in the mange infested Surti buffaloes and buffalo calves. For prevalence study a total of 401 animals were screened for the infection for a period of one year. Systematic and detailed appraisal of haemato-biochemical profiles as well as skin scrapping specimens were carried out in seventy five cases. Hematological analyses of blood samples were done to evaluate changes in Hb, PCV, TEC, TLC and DLC counts. Biochemical analyses of serum samples were done to determine the concentrations of total protein, albumin, globulin, A:G ratio and serum zinc levels by Atomic Absorption Spectrophotometer (AAS). Infestation was found to be high in winter season. Infestation caused anaemia, increased TLC with eosinophilia. There was decrease in total protein as well as zinc concentration in serum in infested buffaloes.
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