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Clinicaf Triaf of the Phytoestrogen-rich
Herb, Pueraria
mirifrca as a Crude Drug in the Tleatment
of
Symptoms
Yeraiing Muangman, M.D.*
Wichai Cherdshewasart,
D.Sc**
in Menopausal Women
pos&.or, phyldrosen-d.h
rh.r h.rb
P'.Nkanile
twh:r.Kvto
Krua) infivc rco,j. votune.B
d in..tud.
drus chrrty inproved
dt!
jGE
rnd synpbm dat.d
,
lrut'ddn,
d..p disrd.., skin drynd,
hjd blmd .hotdker,
G odr.r
physiotogisr
sbtu.fb.fou. dor.bs or.n'b.nr In
lourrolunb
b.dnpLe aom-y.'r b{Fedod ,id
harlrhr dos r.d ws round b n'i
0 m3 4!r, orherdar rdr 20
d!r,
F.
mdnrb3. Tnde dds n.e.rddy.
&d eL s
phyhrns.n.bim.nt
ot m
i.ri.HqnGnr.innin!.{4!ln#n'ttrlt,F
trrL.!d! }di,nnrr,1!
mdnunii$1.Trr'ri!n!r
hlnarltqaAlda{.
Ad*t"dd1dql,
lr!/a1L1sr,1ttd.
enarolittun,s
':lnrtnbr
la4aa,'alniifitivl1
Atut6nn.1dsi..tr1r$rn!tu1ivo1ir,
fitArnlzsaa $ 3aa4as.
nrf, nbrMrn6nnroimu!Filqrlrlroii1(wtr#loisli1n!iun!'o!ii{l]!ht
iiidTklnLoilon{{rir
p!e€,a
mtit€ rtnnmiLriiom!
hfii1.liinn,r.llhiomi
s hu nuir
.i(ni1imi!.rrMssri! nriri!rnltir!filr:ir60!,i!
ornahllln nr:tunred10
lodnvra-!'b[n!it:oi!I,liiMosih'Aor0!
!'y ir6oM:lJi!ne!fu
"';n!.tinr:4do!
bbljjim'
'D.puktdt
.! su(o Frcntt .4
M.dicrz,
4Depatnflt
a! Riot
e\
FQutft of scnne.
chltatonskatlt u^tu.dt,
Baryt'L tB3a, fhoib,n.
inf, o!r$irNiini!$6sx!1lrnifl
r11llooderi!{c
'ddllwlswiqin'doi
vir;u!du6:1r
i!fum1rmdi'iMu6!1 lioiun':mlmfi
n,iofur!a
L6su oldrliara.
diudl.ttdrtaourwrur
nhrron{#r mrlfln r0"!.!i1!Toin!mri!
6mwis'i1itd fnN!.'1lrllnti1frtuU
a !6!!Fniatun:
,00 !n
Inilafirod!
3 ftlt.dh$tiiafit!
ri:ioNL'6o
,00 !n. tlL&iu
6i!6: ,o lirq bi1qm1;!v6i6n
s '6i! milltlt1liurdr.iti
lravinrntrn:liitnodivilldLnllnlnmdlin
urin!md!mm'6r!iir3!
INTRODUCTTON
d
vcd rmm d.crcaFd brood
etuog.n lavek amons
middle .ged fcmalca
Esrosen RePhccmcir
T.erapy
(ERT)
has becn enployed
1o
probd
and
suci 6
lir*ryle chms6 wd.
ptuposd ro minimize
thc nenopausl symphmdr
nl rheEpi*,
q\pccially
soy
pmducb {hich
6ibii
signlfican!
lcvck or
phyro.dlos.ns, nsmely
rcfiavoicr,
*erc shown b be nor
oily.ftedive ii
P ,irf.a
(Airy
sha{
d suvdabadhu) or
vhib Kwao Kna s a Thri
iidisercus herb wi6
'
rnd nenrr. The
hcd ea lisr broush(o
ptrblic
a!
remior ii I932
by a rpon $ar fte lubctu$
mor ot
rnjnal cxpe meni rrd
dliiical tial in a hospibl by
ad m inBrcrins
,lcoholi. cflde ertrer or
rhc hc6 .
such hud,n benefit
ws also coinmcd
by am&er
nudy,'.
Th. hdb Ms inirially
r.osiized N ,!t c
!psr',
and vas linally idcdificd
otrd d.arly e$
bblkhcd s Pcu.ra
rtifa
r.
Acrive inFedici6
vd. isolrtd and 3ed-
i'rd rrcm the herb,l
rtrbei dd vs round b co
M
efi@r s cponed rom rhe nudics
ii inD'rurc te
'irbnnej|andovuelodizednb'"'Averyrner
edms rqdt
els obraiied tom r dinj6l
tid ii iin.
'ie
ingrudicn fiom r 'i4ie muld be admjnF
']!idzii,dsidaii,eenhrein,oumedml. ninficin'r,
senisritr!!,
pucrdin!
and k*rkhrrin! The
phy.
pEv.d
6one
los.l! Drid,.ii wa ftponed b have
infrui..il$n.iis
rcriviry-, inhibirory mrion on
iiducd luig mebd6is" and on spcciric
fuhs..
riciryr. censr.in
Ntr
sho*n
ro havc , icgativc a
brcasi c er celr
prolirmtjoii'rl s ftll s rcduc
tosen supplcnciarnd
an ad{n.op.msn asenr}.
rovdiis {,ion."
p
sirsGrcr *a sho*n b rcdu@
hciicn
pmndc
hypcalasian
r!
and inhibil hum
.olon camer
crcwrh{.
d
lere
m,nficoumcsh
r.d
rtifk wi'h r lons his'ory or consunption @ord.
med ormenopruel symprors,
rhis
pr.limii&y
cliii
cil tial vj'h c u'int.!
iiT hsi romon could help
eriluds ib
p{bdi,l u$ tor lo is renn
phyroshsetr
innitu,
ftrll'sle chndhil. such a tialcoull
MATERIALS AND MEIIIODS
rhD fHh ruber or r ,titm uhjYar
cxduded,Fiveecepledvolunben{crelheou'Pa.
liefuo'RinalhibodjHospirlF&u]ly.fM.ilicilc,
MahidolUnNesitn Bm8to[,T
b,]l,id, wi$ri rgc
bin. haendocrit, blood
urd nihscn, dtudiiind,
scoT,scPr..ho|csml.tic|ycsidssidmiidy
sis Tbc *h.bd
voluiEA had ro be i0 r noflil
hcald
enh ionnsl blood ch.mical milysn resulrs.
llrey
vcr lcrb,lry inromed rbour the debil of rhe
rhe 126 month lte
volude6 hd sisicd, vn!c[
1rrebody
weishr. heth', br
,wrillft
hlpsirsorddvolhtcswcrcrccordcdltr$prior'o
3.2 Mldiclr
In..ni€q
@ns
wid,
$ijdad
qusrioN
ju(
enoi
b 'ic rs, $
bn
pc.idd,
rid
4
rhd
sid ofrh. tzd nonrh E{
RESULTS
yerr
ludy rom fivc scrcdcd vornihn,tu
jndjyi.
ks, bcjshr I 47
n, rrad exp.n.ned amenonho.a
pe
.xhibil.d as hol flus|ts, iiNtdioi, s|ccP di$rdq
loblbloodcouil,idblodd.hchislryala]Fn'*.8
iod, ir *rs fouid
6!!
urd plriofs
appdire incE?sed,
'hebodyweighindtsdby0s|qsdENeEd
rmm ho' nushc, fflshrioi 3nd skin dryrcs
(4pc.
riod.
the recorded nenopausar symproms showcd
rior, sl*pdnord*, and skin dryi*s
Tod
blood
counlandb|oodch.nkl-yamlysjsrcv.a|edlhdlhc
rrr
pdjcrr's
iccordcd weighr i.qeNd
by 0.5 ks
m:in!rq';nNiinixsurnl]lllrtiinl'f
oodliniqij
riod,
rhc fs.ial skm had b40N
tum
llrlc
rhd
hody
flrbodyveishriocrcNedby
3kB
sibrcrssvsre
.hohicror rcver
tnif 247 ro 205
q* (
r?.0% dc
[g$dc(mi@o|d'cmd[trulo{Amlob
pEviouny co'ded reovc.y
rbm mcnopausrsymP.
rhoeiforTmoifis'*d$bmn@nbhgn$4ery
(PDA
I'sdi.D) l3
yeirs
ago.
lodlho rcgularly su,-
un.lrhecidol
rz nonh.Ir vas round rhdJ*P
.bsn( and 6d
vohihr feh d'ar she !a ii a
sodd
rlon
pdiod,
aod rhus, was dasifidd
*olico'ienor
loblb|o0dcoun[lndbLdoddtfktrf,ana|ysisverc
iod,ftchrof
rsrc|[diid€asdby2.5cm.stunil
nu
conplcrior of r[c 4imonth red
P
dy$riaws iiv$rigded'nd vhireblood.ells(6.r0
cdls/HPF)weEroudinurire.shew6tatd'b
ofioxrcin
ror
7
days ad sc
rymprom
vs
errmr
.ryan'yeswcEDomdexccllbloodcholAlero|
At@r
conprerion
oroE
2i
modh Ed
p*
'|e9'9mdhipci(flnfddcsmdih.bodyweigb'
Afrd cohprcrioi of rhc
3d
hood rn
po.
nnfy,n'ysnulciormslcx.cp|bloodchdl4.
kindThcbodyweigh'hadin.f*dlbylkg{hlh
'ioi orr 4i4t.a
code drug.ic sunmart{d
m
ljde erf{ts r soi,naiz.d ri llbG
2.
DISCUSSION
of,? drira dlrive wi.hi.nr w6
Gscd id tlr
m.iorthom synproms
rne En was d.sisnEd
tor 4
The resulrs
(Tabr.
r)
4vcared rhar rwo
ai *hscm
uooN ro fte crude dng $d rdncd.d
4ri6e ouryar wrchai
nr .xhibnd hphrc
efrE6
phyro{roseis
fton
orh* sourc*
T
he rophic
dleds
qere
mcr likely rtrliy ruicoonal
jt
rhc ubrur
rhe nsina ws iod
^ r sisn orrdveBe clld
(Tabte
2). r' wa non rikcry b
cux from cdvi.'t ,ndlor
'fth
rindiic hcrps.offm
fid srosen 6.prd
(ER)
p
k
pcso'
in 'he rMa csjl{
q qgin.r
riniic
ard m rcsesd b
p
''ri6a
pby'cnrcsft
as
!dr.
T.hle
1, Nunbrorssd
surfdrins
wi
irinr\ninNnAnirNdE{!l}rinnul
lrrslen0xd!
305 i':tui dd:,'!,ll! Ln$irii
;
he advcAD
eflmb ,trer ron monrhs omumphon or P rirtr.a crude
or brear nsues b rq
nird.c
nhybshsqs
by {
risid, N rrMys mors by sroc$
i's'
prior
b ,he
hs rspoi$ 'o P attnn
rrcdnsnr
Such
lccumuLni.! wduld dcfinircly c
rbat ERlr is
prescd
abundm'ly ii 'heskio md 'lus
ryp. oi c\poNc ir rry uo(ruu i.r
r
nr rfca phyroA
s'ogei 's
pry'osbecis
no'i r 4t./r4
qrurd
'inyorsksen
rheirfluciceof
P/,rt.anpon
oood
of
rhc crudc dru3 dsiLd |n,m P ,rirrc,
oL
'iijlynishchnggniLdlya'Ibcdo$o'|000ng/
ds4eof|0mdl00mg/tg3w{lii*d{,sc{m.
nod wihDr
aiy $rioN idvere efrcds otu orrhc
ns6isrqlinM6nirorurit!1n:;ifi
ar\ihroalo:rNgr
307
1,:iitri !'enL, ii,
'i*Arinri
P ,i4r.a
rhyro6toscN
lko exhibncd
hor flNh$ in
3 cd*,
wqc ttrlly rccovcd
'nd F
rL,cd
by
a
hdd
mood
io d'o$ 4 d{c
a wdr *
bdtr .ppdirc
ii one cac
T
hcsc lLndin$
we had
lqy imporr(
in mcnopasil
womci
as $6s tom
bd mNd tr frsh,ioi
id orv
'nsEd rhc
$bi.d
iilcso,somcmiiorbdicfireffldslcrca|sol'ouod
rhi
rh! nude druP
could exhibn
n'oE bc
n dMi
,dvctrelliscllidconsudpliotr'Forgxanple.dE
v's dsJricd d adyd.
crred ii ooc
hxnd as ir did
also bc
rc.ognyd
I tophic cffsr
ir rhe othd
hrnd
pdcmia Thc 6tsr
sLe iDdcrc
was cl.silicd
is
r rtirr(cul'ilarwidit
III coda
sie
nili.rnlimoudofisonavoicainily?aibyhjgh
ssiry
ddded rodineLy
by $n
mchodr
'!r.
I vs
mii chenical
ndker rn rhd
dud. drus,
dd
prt
of
ftis iudy
.otrLd rcsulr
prnirlly fton rhe hish
koflrdc
6Ns' ir
c 4i4te sllils
wtrhai-trl
isoll orc
r'oh r ,tilim
qDu
al$ *h'br
ilfrcol
ahoui' ofesrqci. e
ati6cl
phyrcsrqctr
Drrird ii oeron4$l
wdH vi ' 'ne
lhm d
*togen could 6d
3 narunl choi*
lbr csrcser
sd
on rhs olhd
h'id, due ro thc
aeoihric effsb ot
phyroahscm which aE ncdiy
robtly domlnatd
phy
tocrogcn $
opl.'ncnarion
especi,lly
ge
n istcir
4 or r2
oodhs $udied
pqiod. Ii mry bc cAonrblc
bqrrrudc
dd 2 ,itirie
cul'ivtu wiclrar III
dddc
drus
d tlis dos may hc
ii rho high doeg€ rcvd
lid
thtrs
cxhjbns mainly
.ytoroxic or n0utll
bd r01
trophic efrcd ro
rh.
prc.xisrin!
brcd.yn
(ir
prcsd).Irar$dosmisimuhtrdcmcunnccorr
rcw brcfr.y$.
All animal rrcdcd
wirh x ,rrirt.4
or
mne\hl
rhe key chcnic,r
of P i,tlri.,
tso .i
hibitd
ro rcpon ol btu$r
cmcer o(unngiL!x!r,
a5 {dl xs rhccliric,i!i,l
witb mrc$td!
sough 'o concl
c 'ha' P ,t[rc,
.an
Prc'ed
orP t4f.a exhddnd'ry
'o the breasr er
wl'dn3.
pruscd rlr chorce olerodivc
t.dmenr lnr
lrh
,tro
m kr nrcnss Lhf
'hdc oI $y whid
s a
ror rcssrch.s b inv6'i3de
d.eply inb
P u tf.z
placen.d
rnmey
eRD
toi mercprsr
wonen
wirh r reduc.n
.ncrtIisk which h6 bcer
prcviotrdy
2lmoiT'ststAc.HufttrMPiysbdq4i3c
4B'idDD.UnbehDM'Lmd.d.|l|.aJDtbry
6 ADedM,i
A
Polhin
300iqdsic. e d. tuerer
6cBc) by ndoie lid
ion orc
phybqtdeis
x
AC(NOWLEDGEMDNTS
iso0avoneinalysiswirhrhc$dplcof
whn
(wao
Kna.
P z'i'.:6e .ultive wic[,i III. ro Rma'nibodi
krA A aPdLd rujurddoi r sBh sN Nd isl
s.rodtr.
w
Ddn M. Hodwcg w A^ cfosn.
'ri6dr@rta
0.4dm*)rrcnliairud,yidd
nituibr ft.n P@rcrb ainlro I Endotrhor
i
96r I
d|eqhtdft midbnontoidduEotbrcmor
PMdintt@
NliE te6a.1$, n1r11.
3dioi
or
P@en4 'r4.@ rcok zNdutu$i sqc
nom 0. ru'otr@a'b
uinl@ z NdudqEh sqc
d o
0.46iu'usti
ac-srrslhon*oie o
rnnnurqrinr:nn!n!oi!1drl!
rlrn!nD'r'o'0!'oni!E!
.sryeside
fren
Apronu tlt e Phrr€b4nq
P4Bt4r'dd@B
zNibd.rdssc
rrtT:12r
khi&H'Udug]r'fiEiKddPdmlioi.f&!d
son
filt
.ttas8
i ktBavuq Mlhdbr
n'
lFjffcih6lolofuyrcsje.{EiicPfotii|irs'J
vgn.sP'sJonorcE'co|diB.c[on[4d
FailiP'Moo-F
g.tMc.c.4z.d'|fre
ftsderA, Meilq ae
sorbreL- cddd
4i
j6b
Ed r cLii Nft De3 5rr 34 r43
do@obnd,esr*[ddidorbdoru sioleml
(piyb,cdD
tu de ldrher deiisn
pordrc
iy
vo Hdr RL, Fir cs. A'd AE.
0
sro$trd ml
aqd AB.
%D HdE n, corc rP. d d
04lsbrel
P4?e;o nr.trca. Irsk M. sc. Fftd.y of sdde
chddolgkdnUiidsi}sgngkor'frfuid'l9l
dcrcds dPcron niriir@. z N{mfond s.i c
chmal.@s.hhihvaT.sdiH.dd'IdddnadoD
ordcoqnicshl 6 'he&Mr rjlEmdr8
pdodpL
d K"ro K{/, P,.E& n,il.d.
trr
kmvD
wiiiu z. $j s. Mdiin s. d d. Enrce, d4br
(ER)
p,
a mdddioi oi ERd h 6e d.di Eoc Ndl
chihF,
s. cidihE@s P. RdhajaEoj s. dr.
rdti'y nudy of
P@Etu 'ind ^iry shiv d
ooi& frcn P@rcni tuitn od s.n dqht eli