Ranked lists of genes altered by aging in both human and mouse tissues. Tables display age-associated expression patterns for ranked lists of the top 50 genes most strongly (A) increased by aging across all human tissues, (B) decreased by aging across all human tissues, (C) increased by aging in human skin (both sexes), (D) decreased by aging in human skin (both sexes), (E) increased by aging ... [Show full abstract] across all mouse tissues, (F) decreased by aging across all mouse tissues, (G) increased by aging in mouse skin (both sexes) and (H) decreased by aging in mouse skin (both sexes). In each figure (A)–(H), age-associated gene expression patterns in human tissues are displayed in the left panel, and age-associated gene expression patterns in mouse tissues are displayed in the right panel. Ranked lists include only orthologous genes that are shared between humans and mice (and thus may differ from those presented in Figures S1 and S10). In (A), (B), (E) and (F), genes have been ranked according to the total number of significant results observed for a given gene across human and mouse tissues (i.e., the total number of up-triangles per row or the total number of down-triangles per row). Tables (C), (D), (G) and (H) list genes most strongly regulated by aging in skin specifically, with genes first filtered to include only genes significantly altered by age in both sexes of a given species (P<0.05), and then ranked according to the estimated 40-year or 2-year fold-change (old/young; averaged between males and females).