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Abstract

Active immunization of children has been proven very effective in elimination of life threatening complications of many infectious diseases in developed countries. However, as vaccination-preventable infectious diseases and their complications have become rare, the interest focuses on immunization-related adverse reactions. Unfortunately, fear of vaccination-related adverse effects can led to decreased vaccination coverage and subsequent epidemics of infectious diseases. This review includes reports about possible side effects following vaccinations in children with neurological disorders and also published recommendations about vaccinating children with neurological disorders. From all international published data anyone can conclude that vaccines are safer than ever before, but the challenge remains to convey this message to society.
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... L'ADEM post vaccinale è un evento molto raro, compare tra 2 giorni e 4 settimane 35 dopo la somministrazione del vaccino e rappresenta meno del 5% dei casi di ADEM. 43 Prima della somministrazione di altri vaccini deve essere effettuata una attenta valutazione da parte del medico vaccinatore in collaborazione con lo specialista neurologo che tenga conto in particolare del tipo di vaccino che ha prodotto l'evento acuto, dell'andamento a medio lungo termine dell'evento acuto, dell'età del soggetto ed in particolare del tempo trascorso dall'evento acuto, del tipo di vaccino che dovrebbe essere somministrato e del suo specifico rischio-beneficio, facendo riferimento ai criteri riportati nell'introduzione. Inoltre data la possibile condizione di ADEM multifasico si consiglia controllo degli anticorpi liquorali anti-neurone nel tempo a seguito di un primo evento acuto per miglior stima del rapporto rischio-beneficio. ...
... 2-4 mesi) hanno un rischio più basso di avere una convulsione così come di avere altre reazioni avverse. 43,63 Nota 3: una valutazione della letteratura disponibile ha escluso una significativa efficacia della profilassi con paracetamolo somministrato prima della vaccinazione e ogni 4-6 ore per le 24 ore successive nei bambini che hanno una storia personale o familiare di convulsioni febbrili. Pertanto la profilassi farmacologica non è indicata. ...
... 2-4 mesi) hanno un rischio più basso di avere una convulsione così come di avere altre reazioni avverse. 43,63 Crisi d'ansia tutti si ...
... Also, Alguacil-Ramos et al. [17] reported that diphtheria, tetanus, and acellular pertussis (DTaP) had the highest AEFI reported in Spanish children (96.6/100,000 doses). Gkampeta et al. [18] reviewed the association of vaccines with an elevated risk of febrile events. They pointed to seizures after DTP and MMR among the most frequently cited adverse vaccine events in the literature. ...
... It seems that the MMR vaccination is not associated with occurrence of seizures in the first year of life. However, delayed vaccination post 15 months is associated with more postvaccination seizures [18]. Thomas et al. [19] reviewed the AEFIs associated with YF vaccines and reported no cases in children and infants in active surveillance studies. ...
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