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What is against the acceptance of hyperthermia?
... We also study the possible side-effects of the scattered radiation, [51], reduce the risk, and make the method as safe as possible. The acceptance of the new paradigm is a clear demand of the theory and the practice as well [52]. ...
A pilot study is performed for Peyronie’s disease by oncothermia principle with a specially
developed so called androthermia device. The case-studies and the preliminary efficacy results
are promising, and show the feasibility of the new method to treat Peyronie’s disease in various
stages.
... The control study five years later was disappointing [39]. What is the problem [40]? Why are conventional hyperthermia with high preciosity of focusing made by modern techniques of radiofrequency and microwave applications not able to serve the proper deep heating requests? ...
Oncothermia is a method of hyperthermia in oncology, controlling the locally applied deep-heat by selectively targeting the cellular membrane of the malignant cells. The selection of the method is based on various biophysical and biochemical achievements. There are various differences between the malignant and healthy cells, which could be used for their selection by heat targeting. The primary selection factor is a different metabolic activity which creates distinguishable environments of the malignant cells. The other factor is the clear difference of dielectric properties of the membrane and near membrane extracellular electrolytes, marking off the malignancies. There is also a structural factor also, which is clear in the different pathological patterns of the malignancy from their healthy counterparts. This last is described by fractal pattern evaluation technique, which dynamic time-fractal transformation is used for further discernment of the malignancy. My objective is to show a new heating method, which makes oncological hyperthermia controllable and effective.
... [82]; What is against the acceptance of hyperthermia? [83]; Progress in hyperthermia? [84]; Prostate cancer: hot, but hot enough? ...
The very first oncothermia application was electrochemotherapy (ECT) which we showed basically works on the effect of charges pumped into the target by an external electrode. This charge causes special cellular distortion in the target. Its selection was regulated by the invasive insertion of the electrodes. The target tissue in ECT is a part of the closed electric circuit, so it could be directly controlled by the circuit parameters! Neither magnetic nor antenna radiation applications have such possibilities; in those cases the target is independent from the generating electromagnetic source. So in our concept the conduction (as clear as possible) has a central role in treatment control. This was the starting point for electrohyperthermia, the root of the complex oncothermia method.
... However, doubts are fueling intensive debates about the possibilities of clinical hyperthermia [1].The main question, is open: "What is against the acceptance of hyperthermia?" [2]. ...
Hyperthermia method was “reborn” with the electromagnetic applications a century ago when deep heating became a realistic goal. The lack of its wide application is that the locally targeted volume has physiological consequences; the systemic control of the human body tries to compensate the active deviation from the homeostatic equilibrium. Clues for the success of the proper hyperthermia treatment are: (1) accurately select the tumor; (2) do not excite the homeostatic correction feedbacks (like blood-flow); (3) properly select the malignant cells; (4) use an effective cell-killing method for the malignant cells; (4) act on innate and adaptive immune system completing the job. Our objective is making the selected concentration of the electromagnetic energy on the sensitive points of the malignant cells, providing energy liberation in this cellular nanoscopic region by nanothermia (modulated electrothermia).
... Oncothermia formulated a new paradigm: [72], and made it clear "What is against the acceptance of hyperthermia?" [83]. The problem is the misleading aim of getting uncontrollable temperature as dose and ignoring the physiological reaction of the patients. ...
... What is the problem [40]? Why are conventional hyperthermia with high preciosity of focusing made by modern techniques of radiofrequency and microwave applications not able to serve the proper deep heating requests? ...
Oncothermia is a method of hyperthermia in oncology, controlling the locally applied deep heat by selectively targeting the cellular membrane of the malignant cells. The selection of the method is based on various biophysical and biochemical achievements. There are various differences between the malignant and healthy cells, which could be used for their selection by heat targeting. The primary selection factor is a different metabolic activity which creates distinguishable environments of the malignant cells. The other factor is the clear difference of dielectric properties of the membrane and near-membrane extracellular electrolytes, marking off the malignancies. There is also a structural factor, which is clear in the different pathological patterns of the malignancy from their healthy counterparts. This last is described by fractal pattern evaluation technique, in which dynamic time-fractal transformation is used for further discernment of the malignancy. My objective is to show a new heating method, which makes oncological hyperthermia controllable and effective.
... (vii) What is against the acceptance of hyperthermia [33]? ...
Hyperthermia was the very first oncotherapy in human medicine based directly on sacral and philosophical roots in ancient cultures. The discovery of electromagnetism gave new hopes a century ago; however, up to now it has been suffering from lack of wide applications. Oncological hyperthermia struggles with multiple technical and medical problems which are far from the complete solution. Technically, the deep heating, the precise focusing, the technical control, and repeatability are challenging. The missing medical explanation of the phenomenon, together with the he missing measurable dose hinders the acceptance of hyperthermia. The contra-feedback of physiology mechanisms makes this method hardly controllable. Multiple, most promising results and studies are mixed together with some negatives and controversial consequences, causing huge fluctuations of its applications. There are positive and negative “believers” of the method, but the decisional facts are missing. A new way gives shape to the development: heating in nanorange, which could solve most of the open problems in oncological hyperthermia.
... (v) What is against the acceptance of hyperthermia [25]? ...
Hyperthermia is not a widely acknowledged treatment, and there is no consensus even among its users. Its effects are mostly acknowledged, but the clinical studies have many challenging problems. Numerous supporters believe hyperthermia is the future miracle of oncology, and more believe the complete opposite, regarding hyperthermia as ineffective and a dead-end among the methods of oncology. Both approaches are basically wrong. Hyperthermia is one of the tools of oncology, having many problems and requesting detailed research in labs and in clinics. Both believers, positive and negative are annoying: believers must not be the basis of any serious medical approach. The facts are necessary! In this book we try to collect these.
Introductory personal notes: My mother died of cancer …. She was young … She suffered horribly … She could not see me graduate … Many years afterwards, my sister was diagnosed with the same type of cancer … The prognosis was very bad … In the time of my sister’s illness oncothermia was already in use. My sister was rescued. She lives happily ….
Oncological hyperthermia is an ancient method that has been around for thousands of years. Despite this,oncological hyperthermia is still in the early stages of development.Like many such therapies,it lacks adequate treatment experience and long-range,comprehensive statistics that can help us optimize its use for all indications.The reason for this is simply explained by the reason that the overall heating of the locally targeted volume has no adequate harmony between physiology, thermodynamics and technical solutions.Selectively focused heating needs to be applied to the sensitive points of malignant cells in order to liberate energy in the nano-scale cellular region.The present article discusses the mechanisms of heating and the effects of hyperthermia in oncology,and provides a solution by Oncothermia (Nanothermia) which shows efficacy in a wide range of malignancies
Hyperthermia was the very first first oncotherapy in human medicine based directly on sacral and philosophical roots in ancient cultures. The discovery of electromagnetism gave new hopes a century ago, however until up to now it has been suffering from lack of wide applications. Oncological hyperthermia struggles with multiple technical and medical problems which are far from the complete solution. Technically the deepheating, the precise focusing, the technical control and repeatability are challenging. The missing medical explanation of the phenomena, the missing acceptable and measurable dose, and the contra-feedback of physiology mechanisms block its acceptance. Multiple, most promising results and studies are mixed together with some negatives and controversial consequences, causing huge fluctuations of its applications. There are positive and negative “believers” of the method, but the decisional facts are missing. A new way gives shape to the development: heating in nano-range, which could solve most of the open problems in oncological hyperthermia.
Oncothermia is a long-time applied method (since 1989) in oncology. Its clinical results excellently show its advantages, however the details of its mechanism are under investigation even today. The method is based on a self-selective process of energy concentration and targets the membrane of the malignant cell, using the temperature gradient and the beta-dispersion of the membrane proteins. To prove the theory we show the experimental evidences in vitro experiments where we showed the definite difference between the conventional heating and the oncothermia at the same temperature. In the next step, we studied some xenograft nude-mice models, verifying the temperature-dependent and non temperature dependent factors. In addition, the synergic effect with some chemotherapies were studied, having more efficacy of the oncothermia with drugs than the conventional heating. These experiments show the definite advantages of the oncothermia compared to its classical counterpart, acting on the same temperature. We have also proved the beneficial effect of oncothermia treatment in the veterinary practice Oncothermia is applied in numerous clinics and hospitals, and we would like to show some characteristic case-reports and also the clinical benefit on the survival time elongation of liver-, pancreas-, brain-, and lung-tumor-lesions.
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