The Internet of things and services (IOT/IOS) as well as Industrial Internet and Industry 4.0 assume networked products, systems, and service in the future. The value proportion of electronics and software will continually increase with these kinds of products and embedded services. When products communicate with one another over the Internet, we refer Cyberphysical Systems or Cybertronic Systems. The development of these new systems will bring several consequences: interdisciplinary, regional, and organizationally distributed and integrated product development, a rethinking of current construction methods, processes, IT solutions, and organizational forms as well as the demand for consistent process chains based on digital models in the requirement definition, system architecture, product development, simulation, product planning, production, and service. Furthermore, planning and design procedures of all disciplines—mechanical, electronic, and software—must be put to the test and their suitability for a new process model for product, system, and service development checked in order to transit them to a common, integrated, and interdisciplinary method, process, and IT solution approach. This approach to the digitalization of product development is called Engineering 4.0. The methodologies of systems engineering (SE), model-based systems engineering (MBSE) and systems thinking form the foundations. Digitalization of products and product development means a transformation process which rearranges the classic limits of a fragmented and competitive IT solution world, a departure from silo thinking to a consistent, integrational solution approach for engineering. A lightweight and federated engineering backbone (→ System Lifecycle Management, SysLM) will take on the role of data and process integration for the entire product lifecycle, including operations. This chapter will present the foundations, framework conditions, and drivers of digitalization and derive an adjusted construction methodology from the results of this for the development of cybertronic products and systems.