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A dog or a cat has an incidentally detected heart murmur if the murmur is an unexpected discovery during a veterinary consultation that was not initially focused on the cardiovascular system. This document presents approaches for managing dogs and cats that have incidentally-detected heart murmurs, with an emphasis on murmur characteristics, signalment profiling, and multifactorial decision-making to choose an optimal course for a given patient.
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1076 Vet Med Today: Reference Point JAVMA, Vol 246, No. 10, May 15, 2015
dog or a cat has an incidentally detected heart
murmur if the murmur is an unexpected discov-
ery during a veterinary consultation that was not ini-
tially focused on the cardiovascular system. Common
examples include auscultation of a murmur during an
annual wellness examination, prior to general anesthe-
sia, or during evaluation of a patient for a noncardiac
medical condition.
Successful management of an animal with an inci-
dentally detected heart murmur requires a correct diag-
nosis to accomplish the goals of accurate prognostica-
tion, appropriate initiation of treatment if needed, and
having a satisfied client who fully understands the im-
plications of the murmur, including the impact of the
underlying disorder on the animal’s health. This docu-
ment provides current information by species and age
group to help veterinarians make appropriate decisions
and initial diagnostic plans after incidental detection of
a murmur in a dog or cat.
An incidentally detected heart murmur might or
might not require further diagnostic investigation. De-
finitive diagnosis of the cause of a murmur benefits the
patient because it serves as the basis for providing an
appropriate level of treatment and monitoring. It also
provides value for the client (by allowing an accurate
assessment of presence and severity of disease in the
pet and its prognosis) and for the veterinarian (by cor-
roborating or expanding on auscultatory findings and
on understanding of the impact that a given condition
can have on the patient). In general, the veterinarian
who has detected a murmur is in the best position to
develop the initial diagnostic and case management
Management of incidentally detected
heart murmurs in dogs and cats
plans in conjunction with the client, given the veteri-
narian’s familiarity with the patient, the client, and the
characteristics of the murmur as determined by careful
The first and often most challenging step is to de-
termine the clinical importance of a murmur. Its char-
acteristics may suggest that it most likely results from
a cardiovascular lesion (termed pathological murmur)
or that it most likely is associated with a structurally
normal heart (termed nonpathological murmur). The
terms nonpathological murmur, functional murmur,
innocent murmur, and flow murmur are similar inas-
much as they all signify that a murmur is not caused
by a structural cardiovascular lesion; however, each has
a specific meaning (Figure 1).
In this document, non-
pathological murmur will be used as the principal term
to describe murmurs that are not associated with struc-
tural cardiovascular lesions.
Veterinarians investigating the clinical importance
of a heart murmur should optimally include the follow-
ing steps in the patient’s evaluation:
Determine, by careful auscultation, whether the
murmur is most likely to be pathological or non-
pathological (Appendices 1 and 2).
A veterinar-
ian’s ability to make this determination increases
with experience in auscultation of dogs,
but often
it is not possible to classify systolic murmurs of in-
tensity grades 1/6 through 3/6 as clearly pathologi-
cal or nonpathological in cats.
When auscultation reveals that the murmur is con-
vincingly nonpathological, identify and address the
systemic disorder likely causing the murmur (eg,
anemia), if any. In the absence of a systemic cause,
the purpose of further cardiovascular diagnostic
tests is confirmation that the heart is structurally
Reference Point
CHF Congestive heart failure
CKCS Cavalier King Charles Spaniel
DCM Dilated cardiomyopathy
DMVD Degenerative or myxomatous
atrioventricular valve disease
NT-proBNP Amino-terminal pro-B-type natriuretic
VHS Vertebral heart score
VSD Ventricular septal defect
From the Department of Companion Animals, Atlantic Veterinary College,
University of Prince Edward Island, Charlottetown, PE C1A 4P3, Canada
(Côté); Upstate Veterinary Specialties, 222 Troy Schenectady Rd, Latham,
NY 12110 (Edwards); VetCorp Inc, PO Box 1946, Mammoth Lakes, CA
93546 (Ettinger); the Department of Clinical Sciences and Services, Royal
Veterinary College, University of London, Hatfield, Hertfordshire, AL9
7TA, England (Luis Fuentes); VCA Animal Care Center of Sonoma Coun-
ty, 6470 Redwood Dr, Rohnert Park, CA 94928 (MacDonald); the Depart-
ment of Veterinary Clinical Sciences, College of Veterinary Medicine, The
Ohio State University, Columbus, OH 43210 (Scansen); the Department
of Small Animal Services, College of Veterinary Medicine, Oregon State
University, Corvallis, OR 97331 (Sisson); and the Department of Small
Animal Clinical Sciences, Virginia-Maryland Regional College of Veteri-
nary Medicine, Virginia Polytechnic Institute and State University, Blacks-
burg, VA 24061 (Abbott).
Prepared by the Working Group of the American College of Veterinary Internal
Medicine Specialty of Cardiology on Incidentally Detected Heart Murmurs.
Address correspondence to Dr. Côté (
Etienne Côté, DVM; N. Joel Edwards, DVM; Stephen J. Ettinger, DVM; Virginia Luis Fuentes, VetMB, PhD;
Kristin A. MacDonald,
DVM, PhD; Brian A. Scansen, DVM, MS; D. David Sisson, DVM; Jonathan A. Abbott, DVM
JAVMA, Vol 246, No. 10, May 15, 2015 Vet Med Today: Reference Point 1077
When auscultation reveals that the murmur is patho-
logical, or could be either pathological or nonpatho-
logical, use additional information to prioritize dif-
ferential diagnoses according to likelihood and refine
the initial case management plan. This should in-
clude assessment of all of the murmur’s auscultatory
features (eg, where it is heard the loudest [point of
maximal intensity: right or left side of the thorax,
over the base or apex of the heart], whether it radiates
and if so, to which regions of the thorax [or beyond],
the frequency characteristics and sound quality of the
murmur, and whether it is limited to systole). Con-
currently, findings from the remainder of the physical
examination, particularly mucous membrane color,
femoral pulse quality, heart rate and rhythm, and re-
spiratory rate should be considered carefully. Finally,
the patient’s age, breed, sex, and body size can help
the veterinarian consider certain disorders to be more
plausible, or less so, in a specific patient (signalment
profiling). Together, these elements should be used
for creating a differential diagnosis list ranging from
most likely to least likely conditions.
Several important factors then help the veterinar-
ian and client determine whether cardiovascular diag-
nostic testing will be pursued. Indications for further
testing include suspicion of a pathological murmur on
the basis of auscultatory features or difficulty in in-
terpreting the murmur; presence of additional abnor-
mal heart sounds; detection of overt clinical signs that
could be referable to cardiac disease; need to investigate
whether a new murmur is associated with other, seem-
ingly unrelated, findings (eg, shifting leg lameness that
could be associated with infective endocarditis); client
concern, anxiety, or desire to be fully aware of the cause
of the murmur and associated prognosis and treatment
options; the animal’s intended use; whether an event
or intervention that could increase the risk of arrhyth-
mia, CHF, or thromboembolism (eg, general anesthesia
or plane travel) is imminent; and the availability, cost,
and perceived value of diagnostic tests (Figure 2). Two
patients could have identical heart murmurs but be
evaluated differently on the basis of differences in these
factors. Ultimately, the murmur must be evaluated to a
degree that is appropriate for the patient and acceptable
to the veterinarian and the client (Figure 3).
Heart Murmurs in Puppies
Dogs can be considered pediatric patients when
they are between 6 weeks of age and the age of full adult
height and normal organ physiology (6 months in toy
breeds; 1 year in giant breeds).
Nonpathological mur-
murs are commonly recognized in puppies, although
objective information on prevalence and temporal evo-
lution is scarce.
The characteristics of nonpathological
murmurs are described (Appendix 1); anecdotally, the
often-noted musical qualities of nonpathological mur-
Figure 1—Nomenclature of pathological and nonpathological heart murmurs.
1078 Vet Med Today: Reference Point JAVMA, Vol 246, No. 10, May 15, 2015
murs detected in human patients are less commonly
identified in dogs. Nonpathological murmurs also can
be caused by such systemic disturbances as anemia,
and evaluation for noncardiac disorders is warranted in
puppies with incidentally detected murmurs and a his-
tory or physical examination findings consistent with
noncardiac disease.
Pathological murmurs in puppies typically result
from congenital heart malformations. The overall prev-
alence of congenital heart disease has been estimated to
be 4.6 to 8.5 per thousand in clinical populations.
most common congenital heart defects reported in dogs
in the United States include pulmonic stenosis, sub-
valvular aortic stenosis, patent ductus arteriosus, and
Similar findings have been reported for dogs in
Europe, with variations including a high prevalence of
atrial septal defects in France and mitral valve dyspla-
sia in the United Kingdom and France. Although par-
ticular breeds can be predisposed as a group to certain
congenital malformations, the examiner must guard
Figure 2—Illustration depicting degree of importance and likely benefit of cardiovascular diagnostic testing in dogs and cats with
incidentally detected heart murmurs. As the features of a given case move from left to right in the 6 categories shown, the expected
importance and yield of diagnostic tests increase. *Examples of activities that could lead to cardiovascular stress include airplane travel
and general anesthesia.
JAVMA, Vol 246, No. 10, May 15, 2015 Vet Med Today: Reference Point 1079
against applying such generalizations too rigorously to
individual animals.
As mentioned for veterinary patients in general,
the examination is intended to differentiate pathologi-
cal from nonpathological murmurs, and in the case of
pathological murmurs, to narrow down the differential
diagnosis. Two common scenarios are described in the
following sections as practical examples.
Figure 3—Flow diagram of the general approach to evaluation of incidentally detected heart murmurs in dogs and cats. *Circumstances
in which echocardiography of a patient with a convincingly nonpathological murmur could be warranted include plans to breed the ani-
mal or a client’s desire to confirm or refute structural cardiac disease. †Tests should be selected on the basis of logistical limitations and
expected diagnostic yield. PMI = Point of maximal intensity.
1080 Vet Med Today: Reference Point JAVMA, Vol 246, No. 10, May 15, 2015
Scenario 1: A diagnostic evaluation beyond the
physical examination is indicated—Young dogs with
incidentally detected heart murmurs that warrant fur-
ther investigation include those with a continuous
murmur, a diastolic murmur, a murmur that obscures
the second (or both) heart sounds, a murmur accom-
panied by transient abnormal heart sounds (eg, a split
second heart sound), a murmur that radiates to the
carotid region, a systolic murmur best heard at the left
apex over the mitral valve area, or a murmur that is
best heard on the right hemithorax regardless of the
intensity grade of the murmur. In addition, further in-
vestigation is warranted for young dogs with systolic
murmurs of grade 3/6 or louder with a point of maxi-
mal intensity over the left heart base. Any murmur in
a dog that is directly related (eg, parent, offspring, or
sibling) to a dog with known congenital heart disease
warrants further investigation, even if the character-
istics of the murmur suggest it is a nonpathological
murmur, as is common in several breeds.
tional indications for further evaluation include the
finding of a soft murmur in association with abnor-
mal pulsations or distension of jugular veins, abnor-
malities of the femoral arterial pulse (eg, bounding,
or hypokinetic and delayed [parvus et tardus] pulse),
evidence of poor peripheral perfusion, abnormalities
of mucous membrane color, or a cardiac arrhythmia
other than respiratory sinus arrhythmia.
Many young dogs with serious congenital heart de-
fects that have no obvious clinical signs will have easily rec-
ognizable abnormalities on ECG or thoracic radiographs.
Although these methods may offer useful ancillary infor-
mation, they cannot provide a definitive etiologic diagnosis
of the murmur. For example, in a study
to assess the use
of survey radiography for diagnosis of congenital cardiac
anomalies in dogs, the differential diagnoses included the
correct diagnosis for only 21 to 23 of 57 (37% to 40%)
dogs with congenital heart disease. For evaluation of young
dogs, the diagnostic yield of echocardiography is superior
to that of radiographic examination in that it is more likely
to provide information needed to identify a congenital heart
defect and enables the clinician to better assess disease se-
verity, the occurrence of multiple defects, and the suitability
of surgical or medical treatment, and to establish a more ac-
curate prognosis. Echocardiography should be performed
by a cardiologist for greatest accuracy.
The accuracy of
high-resolution Doppler echocardiography for the identifi-
cation of congenital heart defects is well established.
Scenario 2: A diagnostic evaluation beyond the
physical examination may or may not be indicated or
can be deferred—In a young dog, a grade 1/6 to 2/6,
short-duration, systolic heart murmur (eg, a midsystol-
ic murmur with clearly audible first and second heart
sounds) that is localized to the region of the left heart
base is typically nonpathological. Such a finding would
not necessarily indicate the need for diagnostic tests but
would warrant a discussion with the client regarding the
advisability of further evaluation. Considerations would
include complete identification and description of the
murmur’s characteristics, the breed of dog and its athleti-
cism or intended purpose (breeding, field trial, or other),
and the concerns and desires of the client (Figure 2).
With auscultation alone, it is difficult or impos-
sible to distinguish a nonpathological murmur from a
murmur with similar characteristics that is caused by a
trivial congenital lesion. This issue has little practical
importance in management of most dogs; a very mild
subaortic stenosis lesion, for example, would not be
expected to substantially impact the health of a given
patient. In a situation such as this, watchful waiting
can be a reasonable approach if additional features of
the case suggest that the importance of further diagnos-
tic testing will be low (Figure 2). However, such dogs
should not be bred until a definitive diagnosis is estab-
lished, which usually requires a complete echocardio-
graphic examination.
Heart Murmurs in Adult Dogs
Systolic murmurs are more common than diastolic
or continuous murmurs in adult dogs. Diastolic or con-
tinuous murmurs are invariably pathological and in all
cases should be investigated with echocardiography,
considering that these dogs can benefit from definitive
clinical diagnosis and treatment (eg, confirmation and
treatment of infective endocarditis or surgical or cathe-
ter-based closure of patent ductus arteriosus).
When a veterinarian detects a systolic murmur inci-
dentally, it is appropriate to seek a second opinion from
a cardiologist, who may make an assessment on the ba-
sis of auscultation or, if deemed necessary, echocardiog-
raphy. This approach may not be feasible for every pet
owner, however. A skilled veterinarian often can make a
provisional diagnosis on the basis of history and a physi-
cal examination that includes careful cardiac ausculta-
tion. For some clients and their pets, this approach can
be sufficient, whereas for others it might not be (Figure
2). Nonpathological systolic ejection murmurs (Appen-
dix 1) may be due to identifiable extracardiac disorders,
for which an in-depth cardiac evaluation is not needed.
When such a murmur is detected incidentally in adult
dogs and a plausible systemic cause is identified, the
evaluative approach can proceed as described in scenar-
io 2 for pediatric dogs with murmurs that may or may
not require further cardiovascular system testing. It is
expected that the murmur will resolve with normaliza-
tion of the systemic disturbance, and if not, cardiovas-
cular diagnostic testing should be performed.
Acoustic features of a murmur may further narrow
down the differential diagnosis at the time of ausculta-
tion. Ventricular septal defect and DMVD are examples
of disorders that cause so-called plateau-shaped sys-
tolic murmurs, which are named this way because of
their phonocardiographic appearance. Plateau-shaped
murmurs are recognized on auscultation by a similar
sound intensity throughout systole, and, typically, their
obliteration of the second heart sound. Conversely, sub-
aortic stenosis and pulmonic stenosis are examples of
disorders that cause systolic ejection murmurs. Ejection
murmurs have a crescendo (ie, increase in loudness dur-
ing systole) or crescendo-decrescendo (ie, loudest dur-
ing midsystole) character and do not typically interfere
with audibility of the second heart sound. In some adult
dogs, the sound intensity profile of a murmur—corre-
sponding to its phonocardiographic shape—can be dif-
JAVMA, Vol 246, No. 10, May 15, 2015 Vet Med Today: Reference Point 1081
ficult to discern on auscultation, making the auditory
distinction between plateau murmurs and ejection mur-
murs difficult. If auscultation results are ambiguous in
this respect, further diagnostic testing is justified.
The location of a murmur’s point of maximal inten-
sity also is helpful for identifying the likely cause of the
murmur. For example, an investigation
of the diagnos-
tic accuracy of auscultation for identification of mitral
regurgitation in Whippets revealed that auscultation of
any murmur was associated with very low specificity:
false-positive diagnoses of mitral regurgitation were
made for 166 of 186 (89%) dogs with murmurs. Partly,
this likely reflected the high prevalence of functional
left basilar murmurs in Whippets; indeed, when only
those murmurs heard over the left cardiac apex were
considered, indices of diagnostic accuracy substantially
improved and the frequency of false-positive diagnoses
decreased to 15 of 186 (8%).
Finally, murmur intensity, or loudness, is of some
limited benefit in determining severity of mitral valvu-
lar regurgitation in adult small-breed dogs with DMVD.
Overall, adult small-breed dogs typically have a larger
amount of mitral regurgitation if the murmur is louder
(corresponding to a higher grade).
This generaliza-
tion, however, cannot be used for providing a precise
prognosis for individual patients because body condi-
tion, orientation of the regurgitant jet, and sympathetic
activation may alter a murmur’s grade irrespective of
the severity of DMVD.
Some veterinary cardiologists deliberately auscult
adult dogs at rest and again immediately after exercise
as a means of identifying flow-dependent or heart rate–
associated murmurs. For example, whereas 68 of 100
(68%) auscultations in 19 Boxers revealed a murmur at
rest, 95 (95%) of auscultations of the same dogs revealed
a murmur after the dogs had 3 minutes of exercise in 1
Furthermore, murmur intensity increased after
exercise; 2 of 100 (2%) murmurs were grade 3/6 with
exercise, compared with 0 (0%) at rest; 74 (74%) were
grade 2/6 after exercise, compared with 24 (24%) at rest;
and 19 (19%) were grade 1/6 after exercise, compared
with 44 (44%) at rest.
The practice of auscultation af-
ter physical exercise increases the rate of detection of
pathological murmurs and nonpathological murmurs.
Therefore, it may be considered when the veterinarian
and the client understand that the emergence of a new
murmur at a higher heart rate is not a conclusive find-
ing, but justification for additional diagnostic testing.
In an adult dog, systolic murmurs heard loudest
over the left cardiac apex are most commonly caused
by mitral regurgitation; in turn, the most frequent cause
of mitral regurgitation is DMVD, but DCM, infective
endocarditis, and congenital mitral valve dysplasia are
also recognized causes of mitral regurgitation. Systolic
murmurs heard best over the left heart base are man-
aged in adult dogs as described for puppies. Systolic
murmurs that are loudest over the right hemithorax are
most commonly caused by tricuspid valve regurgitation
(with or without pulmonary hypertension), subaortic
stenosis, or VSD, and further evaluation should be con-
sidered on the basis of concomitant factors (Figure 2).
In conjunction with the features of the murmur,
signalment profiling can be helpful. The simple process
of evaluating the murmur’s characteristics together with
the patient’s signalment narrows the differential diagno-
sis and helps the practitioner select appropriate diag-
nostic tests (Figures 4 and 5). This process is illustrated
with 2 examples.
Example 1: Evaluation of a small-breed (< 20 kg
[44 lb]) adult dog with a systolic murmur loudest over
the left apex—This type of murmur may be pathological
(eg, DMVD, mitral valve dysplasia, or infective endocar-
ditis of the mitral valve) or nonpathological (eg, anemia
or breed-associated or individual variation). Auscultatory
features of the murmur help make this distinction (Ap-
pendix 1), as do extracardiac observations (eg, pallor, sug-
gesting anemia) and the prevalence of specific disorders
in the patient’s breed. If uncertainty persists despite these
observations, or if the murmur is convincingly pathologi-
cal, additional investigation is justified (Figure 3).
Echocardiography provides a more precise and
more accurate diagnosis of the cause of a murmur than
does radiographic examination and is advised; however,
thoracic radiography often is performed first because of
lower cost, greater availability than echocardiography,
and ability to identify pulmonary and vascular abnor-
malities. Absence of radiographic evidence of cardio-
megaly in an adult dog with a systolic left apical mur-
mur suggests a nonpathological murmur, mild heart
disease (eg, early stage of DMVD), or heart disease
that may be clinically important but not yet associated
with cardiomegaly (eg, infective endocarditis). In adult
small-breed dogs with incidentally detected murmurs,
clinically important heart disease is uncommon if tho-
racic radiographic findings are normal. The decision to
pursue further diagnostic testing should be based on
assessment of all factors that pertain to the case (Fig-
ure 2). Echocardiography performed by a cardiologist
is the gold standard for identifying the cause of such
Assessment of circulating NT-proBNP con-
centrations provides additional information of limited
value in this situation; for example, in a study
of dogs
with preclinical DMVD, the median NT-proBNP con-
centration was significantly (P < 0.001) higher in dogs
with cardiomegaly than in those with a cardiac silhou-
ette of normal size.
However, the range of results was
broad, and many clinical results can be expected to fall
in a range of overlap between radiographically normal
heart size and cardiomegaly, conferring limited use for
clinical decision making for individual patients.
In adult small-breed dogs with incidentally detected
murmurs, serial follow-up of cardiac size on thoracic
radiographs can be a useful tool to monitor disease pro-
gression (Figure 4). For example, CKCS with DMVD
may have a VHS that is stable and may not have clinical
signs for years, followed by a rapid increase in VHS and,
eventually, the development of CHF. In a longitudinal
study of 94 CKCS with DMVD, the median VHS was 11
at 3.5 to 4 years, 11 at 2.5 to 3 years, 11.25 at 1.5 to 2
years, and 11.7 at 0.5 to 1 year before diagnosis of CHF;
at the onset of CHF, the median VHS had increased to
Thus, in a typical case, an unchanging VHS of
10.6 to 11.3 in an adult CKCS with an incidentally iden-
tified left apical systolic murmur is unlikely to reflect ex-
tensive cardiac changes or imminent CHF.
1082 Vet Med Today: Reference Point JAVMA, Vol 246, No. 10, May 15, 2015
Example 2: Assessment of a large-breed ( 20 kg)
adult dog with a systolic murmur loudest over the
left apex—The causes of left apical systolic murmurs
in large-breed dogs are similar to those for small-breed
dogs. However, the prevalences of individual diseases in
the 2 populations generally are very different, and fewer
conclusions may be reached confidently on the basis of
physical examination results alone for large-breed dogs.
Indeed, differentiation between the principal causes of
left apical systolic murmurs in large-breed dogs via aus-
cultation alone is unreliable, and thoracic radiographs
may reveal few or no abnormalities in the early stages
of disease. Therefore, the single best diagnostic test for
evaluating an adult large-breed dog with an incidentally
discovered murmur is echocardiography (Figure 5).
Nonpathological murmurs must be considered
first, and their point of maximal intensity is rarely the
cardiac apex. If nonpathological murmurs are consid-
ered less likely on the basis of auscultatory features
(Appendix 1) and the rest of the physical examination
does not reveal a likely basis for a nonpathological mur-
mur, a pathological murmur is more likely and further
diagnostic testing is recommended. In adult large-breed
dogs, disorders that produce systolic murmurs that are
loudest over the left apex include DCM,
mitral valve
dysplasia, DMVD of large-breed dogs,
and infective
endocarditis. In large-breed dogs, DCM and DMVD
often produce soft, systolic, plateau-type murmurs, de-
spite a potentially aggressive disease course over time.
If the dog’s breed or other features suggest a particular
disorder, the differential diagnosis may be narrowed or
better prioritized, but not to the point of eliminating the
need for echocardiography in adult large-breed dogs.
Inevitably, the distinction between large- and
small-breed dogs involves overlap with dogs of an in-
termediate body size. It is also possible for small-breed
dogs to develop heart diseases that occur more com-
monly in large-breed dogs, and vice versa. Therefore,
the examples provided here should be considered to of-
fer general diagnostic approaches that need to be modi-
fied when individual variations are encountered.
Heart Murmurs in Geriatric Dogs
A geriatric animal is one that has entered the last
25% of the average expected lifespan for the species and
Figure 4—Flow diagram of a diagnostic testing approach for assessment of an adult small-breed (< 20 kg [44 lb]) dog with an incidentally
detected left apical systolic heart murmur and no overt signs of CHF. *Relevant conditions include chronic kidney disease, adrenal gland
disease, or diabetes mellitus. †Recommended for patients that have comorbidities or that are receiving treatment for CHF, cardiac ar-
rhythmias, myocardial systolic dysfunction, or any combination of these disorders. ABP = Arterial blood pressure measurement. SBA =
Serum biochemical analysis. UA = Urinalysis.
JAVMA, Vol 246, No. 10, May 15, 2015 Vet Med Today: Reference Point 1083
In this age group, murmurs due to congeni-
tal heart disease are identified occasionally,
but those
caused by adult-onset heart disease are much more
prevalent. Features of the cardiac auscultation and the
rest of the physical examination are at the core of an
accurate differential diagnosis. Characterization of the
murmur’s sound quality, point of maximal intensity, and
timing allow a skilled veterinarian to differentiate ini-
tially between findings suggestive of common disorders
versus those that suggest unusual disorders. For exam-
ple, a 10-year-old Dachshund with an incidentally de-
tected, grade 4/6 systolic left apical murmur most likely
has DMVD, but an otherwise similar dog with a grade
4/6 left basilar systolic murmur that radiates to the ca-
rotid region almost certainly has a disorder other than
DMVD. In each case, the veterinarian’s confidence in the
presumptive diagnosis helps guide the client’s decision
on whether to pursue diagnostic testing (Figure 2).
Geriatric small-breed dogs with murmurs common-
ly have DMVD, particularly if the murmur is systolic and
Figure 5—Flow diagram of a diagnostic testing approach for assessment of an adult large-breed ( 20 kg) dog with an incidentally
detected left apical systolic heart murmur and no overt signs of CHF. It should be noted that, in the absence of echocardiography, the
cause of most systolic murmurs in large-breed dogs cannot be determined definitively; thoracic radiography then becomes the most
important test to evaluate for cardiomegaly or evidence of CHF. Recommendations are provided for the most common causes of mur-
murs in adult dogs; others are possible but less prevalent. ‡In specific cases, measurement of analyte concentrations can be beneficial.
LA = Left atrium. Lab = Laboratory tests. T
= Thyroxine concentration. XR = Radiography. See Figure 4 for remainder of key.
1084 Vet Med Today: Reference Point JAVMA, Vol 246, No. 10, May 15, 2015
loudest over the left apex.
The demarcation between
adult and geriatric age groups must be considered indis-
tinct, and different breeds have characteristic prevalenc-
es of murmurs that span the adult and geriatric age cat-
egories. Results of 1 retrospective study
indicated that
a left apical systolic murmur develops in approximately
20% of each of the following dog breeds by these median
ages: CKCS by 4 years of age, Shih Tzus by 8.6 years
of age, Dachshunds by 9.5 years of age, Bichon Frisés
by 10.4 years of age, Miniature Poodles by 11.1 years
of age, Yorkshire Terriers by 12.7 years of age, and Lha-
sa Apsos by 13.2 years of age, with DMVD as the most
likely cause. Thus in geriatric dogs, or any adult dogs
of unknown age, signalment profiling is a useful tool in
developing and prioritizing differential diagnoses. This
process helps the veterinarian offer general guidance to a
client but does not replace the information provided by
thoracic radiography, echocardiography, or both.
In the absence of any other clinical signs possibly
related to heart disease, geriatric small-breed dogs with
systolic murmurs that have a point of maximal intensity
over the left apex can be evaluated by thoracic radiogra-
phy. As mentioned for adult small-breed dogs (example
1), thoracic radiographs can provide important prog-
nostic and therapeutic information for patients with
presumed or confirmed DMVD: a cardiac silhouette of
normal size and shape in a dog that has no overt signs
of decompensated heart disease is consistent with mild
DMVD, and no treatment currently available appears to
alter the progression of DMVD at this stage. Addition-
ally, such radiographs may then provide baseline infor-
mation for comparison as the disease progresses.
Echocardiography can provide clinically important
information about any geriatric dog with an inciden-
tally detected murmur. It is especially warranted if the
murmur has a point of maximal intensity over the right
hemithorax or is equally loud on the right and left sides
of the thorax; is loudest over the heart base; radiates
to the thoracic inlet, carotid arteries, or both; or is dia-
stolic or continuous. An echocardiogram is indicated
in a geriatric dog with a murmur that is accompanied
by a cardiac arrhythmia other than respiratory sinus
arrhythmia, distension or abnormal pulsations of the
jugular veins, or abnormalities of the femoral arterial
pulse. A murmur that is recent in onset and coexists
with vague systemic signs justifies diagnostic testing to
address the possibility of infective endocarditis.
A left apical systolic murmur might be detected in-
cidentally in a geriatric small-breed dog with signs the
client attributes to aging, including exercise intolerance
and decreased interaction with people, but such signs
can be caused by heart disease. In this instance, thoracic
radiographs and clinicopathologic tests (eg, CBC, serum
biochemical analysis, and urinalysis as appropriate) are
warranted; a radiographically normal cardiac size less-
ens the likelihood of a cardiogenic basis for the signs,
whereas cardiomegaly should prompt a recommenda-
tion for echocardiography to differentiate structural
heart disease from a large cardiac silhouette caused by
innocuous technical or individual animal factors.
In medium-, large-, and giant-breed geriatric dogs
with incidentally detected left apical systolic murmurs,
it is important to consider that the murmur may be
caused by such disorders as DMVD, which can progress
more rapidly in large- than in small-breed dogs; DCM;
or infective endocarditis. Therefore, in dogs that weigh
approximately 20 kg or more, a left apical systolic mur-
mur should prompt a recommendation for echocar-
diography as the initial diagnostic test of choice.
Heart murmurs that are convincingly nonpatho-
logical on the basis of a thorough auscultation are by
definition not caused by structural heart disease and
therefore do not require radiographic or echocardio-
graphic evaluation. As noted previously, it may be diffi-
cult to differentiate nonpathological murmurs from soft
pathological murmurs, and any uncertainty warrants
additional evaluation as appropriate for the signalment
of the patient; auscultation by a cardiologist or echo-
cardiography would be logical choices in this context.
Heart Murmurs in Kittens
The pediatric age group for cats can be considered
to include patients 6 months of age,
which is roughly
analogous to the pediatric population in human medi-
cine. In these young cats, the prevalence of congenital
heart disease has been estimated at 1.6% and 5% in adop-
tion centers and the referral setting, respectively.
It is
important to consider that young cats may have heart
diseases commonly recognized in adult cats (notably
hypertrophic cardiomyopathy), and that nonpathologi-
cal murmurs can occur in cats of any age.
In young cats, a nonpathological murmur may be
caused by systemic disturbances (eg, anemia) or iatro-
genic factors (eg, excitement) or can be detected in pa-
tients with no identifiable systemic or structural cardio-
vascular disorder.
Murmurs attributable to anemia may
be somewhat easier to recognize in young cats because
they often have a Hct that is below laboratory reference
intervals for adult cats and have a thin chest wall. These
murmurs are high-frequency, mid-systolic (whereby
the first and second heart sounds still are heard clearly),
and often soft and variable in their intensity depending
on the severity of the anemia but seldom of grade > 2/6.
They often are best heard at the left heart base or apex.
Concurrent findings of pallor or other physical abnor-
malities should be evaluated because the murmur, in
such instances, might be only 1 indicator of a systemic
The specific characteristics that separate patho-
logical and nonpathological murmurs fail to reliably
do so in most cats with grade 1/6 to 3/6 systolic mur-
murs. This uncertainty can be addressed with 1 of 3 ap-
proaches: further cardiovascular diagnostic testing, (eg,
Doppler echocardiography), second-opinion auscul-
tation by a cardiologist, or simple reexamination and
reauscultation, typically after a period of 2 to 4 weeks.
A pediatric stethoscope is often helpful for accurate
auscultation of kittens and small cats. The course to be
pursued should be decided on the basis of perceived ad-
vantages and liabilities of each approach and is a matter
for discussion between the veterinarian and the client
according to several important criteria (Figure 2). A
persistent, soft, left parasternal murmur may be either
pathological or nonpathological, and this distinction
is best made by Doppler echocardiography. As another
example, there is a greater incentive to obtain an echo-
cardiographic diagnosis when a murmur is detected in-
JAVMA, Vol 246, No. 10, May 15, 2015 Vet Med Today: Reference Point 1085
cidentally in a young cat that is a member of a breeding
colony or is scheduled to undergo general anesthesia,
to assist with breeding decisions and anesthetic plan-
ning, respectively.
When young cats have incidentally detected mur-
murs with clearly pathological characteristics (Appen-
dix 1), diagnostic testing is warranted. Except for most
cases of patent ductus arteriosus in cats with normal
pulmonary artery pressures, where a continuous mur-
mur is evident,
congenital cardiac malformations in
cats generally produce a systolic murmur. Murmur in-
tensity and location, while helpful for narrowing the
differential diagnosis list, have limited value regarding
specific diagnosis and prognosis in cats. Cats with clini-
cally unimportant VSDs routinely have loud (eg, grade
5/6) systolic murmurs, and murmur intensity cannot
be used for judging lesion severity. In this age group,
2-D and Doppler echocardiography by a cardiologist
are recommended for diagnosis and prognosis because
they are the most effective means of identifying the le-
sion and its degree of severity, concurrent defects, risk
of complications, need and options for corrective treat-
ment, and broad prognosis. Thoracic radiographs are of
value, and a cardiac silhouette of normal size, in the ab-
sence of evidence of pulmonary abnormalities, provides
some reassurance that severe congenital heart disease is
unlikely. However, assessment of cardiac size on tho-
racic radiographs in young cats can have limited accu-
racy; structural heart disease can be wrongly suspected
if peritoneopericardial diaphragmatic hernia causes a
large cardiac silhouette in a cat with a normal heart, and
conversely, it may be missed if the murmur is caused by
a congenital malformation that causes concentric ven-
tricular hypertrophy.
Heart Murmurs in Adult and Geriatric Cats
Systolic murmurs are common in overtly healthy
adult cats and have been reported to affect 16 of 103
(16%) to 44 of 100 (44%) cats ausculted by veterinar-
ians in hospital and shelter settings.
The frequency
of murmur detection appears to increase with repeated
and with stimulation of the cat.
Among adult cats with incidentally detected mur-
murs but no overt clinical signs, the prevalence of heart
disease has been reported as 16 of 103 (16%) to 44 of
57 (77%), varying by geographic location, examiners,
and study methods.
The most common underly-
ing heart disease in adult cats is hypertrophic cardiomy-
opathy (found in 15/103 [15%] to 38/61 [62%] of adult
cats with incidentally detected murmurs), and the most
common nonpathological murmur is caused by dynamic
right ventricular outflow tract obstruction (8/103 [8%]
to 9/57 [16%] of adult cats with incidentally detected
Subjectively, there is extensive overlap be-
tween the auscultatory characteristics of murmurs caused
by cardiomyopathy and those resulting from nonpatho-
logical murmurs in cats, and generally, these cannot be
differentiated from each other by auscultation alone. Aus-
cultation of other cardiac abnormalities such as a gallop
sound or arrhythmia might be even more valuable than
the detection of a murmur for identifying cats at increased
risk for CHF or arterial thromboembolism.
Clients might not recognize clinical signs initial-
ly, but a veterinarian can detect extracardiac physical
findings that suggest a systemic disorder, and a client
could then realize retrospectively that clinical signs
were present after they have resolved with treatment.
This scenario is particularly relevant for geriatric cats,
in which hyperthyroidism, other disorders causing sys-
temic hypertension, and anemia are more prevalent
than in younger cats and can cause a nonpathological
murmur that resolves with identification and treatment
of the underlying disorder (Figure 6).
Before auscultation, important features of the physi-
cal examination include precordial palpation, because an
increase in the force of the cardiac beat at the apex can
occur with cardiomegaly or with diseases such as hyper-
thyroidism that are associated with high cardiac output,
and a thrill indicates a murmur grade 5/6; mucous
membrane color, because pallor could suggest anemia as
the cause of a murmur; evaluation of the neck for jugular
distension and the abdomen for ascites, both of which
are very uncommon in overtly healthy cats; and pulse
quality, which is highly variable in cats.
A systematic evaluation of the murmur’s character-
istics is indicated when a heart murmur is detected in a
cat. The small size of the heart in cats can make specific
distinctions between sounds with greatest intensity at the
apex or base challenging in some; a common oversight
is failure to auscult parasternally and over the sternum
specifically. In cats, murmurs are often labile, changing
in intensity with excitement or heart rate, or simply in-
creasing or decreasing in intensity over time.
finding has little diagnostic value because it may occur
with pathological or nonpathological murmurs.
alization can narrow the differential diagnosis list in some
patients. For example, right-sided systolic murmurs in
adult cats are more commonly caused by dynamic right
ventricular outflow tract obstruction, hypertrophic ob-
structive cardiomyopathy, or congenital malformations
(notably tricuspid dysplasia and VSD).
Thoracic radiography can be helpful for detection
of advanced cardiac disorders: a VHS > 9.3 in cats is
strongly associated with cardiac disease as a cause for
However, in cats with incidentally detected
murmurs (where clinical signs are absent by definition),
a higher rate of false-negative results could be expected
than for cats with signs referable to the cardiovascular
system. Measurement of circulating NT-proBNP concen-
tration also has value for detection of occult cardiomy-
opathy; in 1 study,
a result < 50 pmol/L indicated car-
diomyopathy was very unlikely, whereas a result > 100
pmol/L suggested cardiomyopathy was present.Thoracic
radiography, NT-proBNP testing, or both may be useful
when client limitations (financial, logistic, geographic, or
other) prevent the cat from undergoing complete 2-D and
Doppler echocardiography (Figure 6). Echocardiography
is considered the diagnostic test of choice for pinpointing
the cause of a murmur. Furthermore, echocardiography
was found to have superior results, compared with radi-
ography (28% to 72% accuracy) or ECG (12% to 60%
accuracy) for identifying left atrial enlargement in cats,
and left atrial enlargement is probably the most impor-
tant risk factor for adverse cardiac events and shortened
survival among many types of heart diseases of cats.
1086 Vet Med Today: Reference Point JAVMA, Vol 246, No. 10, May 15, 2015
Areas of Uncertainty
Many aspects of heart murmur assessment deserve
greater attention. The following specific areas represent
points that are especially relevant to a clinical setting.
Overlap between healthy animals with nonpatho-
logical murmurs and animals with mild forms of heart
disease—It can be challenging even for experienced car-
diologists to differentiate healthy animals with nonpatho-
logical heart murmurs from those with mild outflow
tract obstruction or other subtle structural heart lesions.
Breed-associated overlap between physiologic variants
and pathological lesions has been investigated in Boxers,
Whippets, and other breeds.
It may not be important
to differentiate functional murmurs from murmurs asso-
ciated with mild forms of heart disease in pet animals, as
their management will be similar. It can be more impor-
Figure 6—Flow diagram depicting a general diagnostic testing approach for assessment of an adult (> 6 months of age) cat with an
incidentally detected heart murmur. Dashed lines indicate areas of investigation or controversy where several approaches are possible.
*Echocardiography may still be considered if other features support it. †Circulating concentration (pmol/L). RI = Reference interval. See
Figures 4 and 5 for remainder of key.
JAVMA, Vol 246, No. 10, May 15, 2015 Vet Med Today: Reference Point 1087
tant to make this distinction in breeding animals, how-
ever, because an affected animal may have clinically un-
important heart disease but be capable of transmitting a
predisposition to developing heart disease to its progeny.
Integration and value of newer diagnostic tests
Diagnostic tests of blood, serum, or plasma (eg, circulat-
ing concentrations of biomarkers for cardiac disease) of-
fer the promise of information obtained without requir-
ing referral for echocardiographic evaluation, although
the cause of a heart murmur cannot be concluded from
evaluation of bloodborne cardiac biomarkers alone. In-
vestigations of such assays in large series of animals with
similar murmurs would be useful; for example, differ-
ences may be detectable between dogs with pathological
murmurs and dogs with nonpathological murmurs of
similar intensity and character. Furthermore, assessment
of the role of circulating biomarker assays as one of mul-
tiple components of a diagnostic evaluation (eg, assess-
ment of thoracic radiographs and serum biomarker con-
centrations together, compared with echocardiographic
examination) in dogs or cats with incidentally detected
murmurs could be of clinical benefit.
Outcome evaluation—The authors are aware of no
specific studies that describe the long-term outcomes of
dogs or cats that underwent diagnostic evaluation of in-
cidentally detected heart murmurs, compared with those
in which murmurs were not evaluated further. Neverthe-
less, it is self-evident that failure to diagnose the cause of
a murmur can sometimes lead to a worse outcome. In 1
retrospective study,
dogs with severe pulmonic stenosis
that did not undergo balloon-valve dilation had a worse
outcome than those that did; the same results have been
found for dogs with corrected versus uncorrected patent
ductus arteriosus in multiple studies.
Failure to iden-
tify advanced cardiac disease prior to general anesthesia
or IV fluid therapy can result in unexpected signs of CHF.
Conversely, failure to identify a murmur as nonpathologi-
cal (and therefore clinically benign) can lead to needless
owner anxiety and an unjustifiably guarded prognosis.
Whether the benefit of diagnosing the cause of a
murmur is distributed equally across different diseases,
species and breeds, and murmur types is not known.
Similarly, many other important questions remain, in-
cluding which subgroups of patients receive the great-
est long-term benefit from diagnostic testing, the rec-
ommended interval and methods for follow-up, and the
costs and benefits of reevaluation at various intervals.
It is easy to recommend that all patients with inciden-
tally detected heart murmurs undergo echocardiography.
A true understanding of the realities and imperatives of
clinical practice says otherwise. This report is intended to
provide a summary of the patient-, client-, and veterinarian-
based factors that can help attending veterinarians recom-
mend whether or not to pursue further diagnostic evalua-
tion of patients with incidentally detected murmurs and the
advantages and suitability of various diagnostic approaches.
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tected heart murmurs in dogs and cats and a client information
sheet are posted with the article at
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1088 Vet Med Today: Reference Point JAVMA, Vol 246, No. 10, May 15, 2015
Appendix 1
Criteria for helping differentiate nonpathological from pathological heart murmurs in dogs and cats.
Appendix 2
Heart murmur grading scale.
Grade Features of cardiac auscultation and palpation
1/6 Nearly imperceptible, may be heard with very careful auscultation in a quiet environment; always focal
2/6 Heard readily but very soft; always focal
3/6 Heard readily, moderate intensity; usually regional (can be heard in several auscultatory regions of the heart)
4/6 Heard readily, loud, and usually radiates widely (can be heard in most or all auscultatory regions of the heart), but without a
palpable thrill
5/6 Heard readily, loud, and associated with a precordial thrill, but the murmur is not heard with the stethoscope lifted off the surface
of the thorax
6/6 Heard readily, loud, associated with a precordial thrill, and the murmur remains audible with the stethoscope lifted 1 cm off the
surface of the thorax
(Modified from Ettinger SJ, Suter PF. Heart sounds and phonocardiography. In: Canine cardiology. St Louis: Saunders-Elsevier, 1970;12–39.
Reprinted with permission.)
Descriptor A nonpathological murmur is more likely A pathological murmur is more likely
Sensitive The murmur is absent or much softer at rest than with The murmur is present at rest or with activity; it can be
excitement or exercise; it changes with position or heard at all times
phase of respiration
Short The murmur is of short duration, predominantly heard in The murmur remains loud through most of systole
early or midsystole
Single There are no other associated abnormal heart sounds or Additional auscultatory abnormalities are present, there
physical examination abnormalities; no clicks, gallops, are other abnormalities on physical examination, or both
or arrhythmias are heard
Small The murmur is localized to the left heart base or to 1 location; The murmur radiates from the point of maximal intensity
it does not radiate
Soft The murmur is soft or quiet; generally grade 1/6 or 2/6 The murmur is loud (ie, grade 3/6 or louder)
Systolic The murmur duration is limited to midsystole The murmur is continuous or a diastolic component
is also audible
Evaluation of murmurs with the 6-S rubric can be a useful means to help determine the need for additional diagnostic testing. It is imortant
to note that pathological murmurs may, if caused by lesions that generate minimal turbulence, be mistaken for nonpathological murmurs. (Modi-
fied from Bronzetti G, Corzani A. The seven “S” murmurs: an alliteration about innocent murmurs in cardiac auscultation. Clin Pediatr (Phila)
2010;49:713, © 2010 by SAGE Publications. Reprinted by permission of SAGE Publications.)
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... Most puppies with a congenital heart disease show no clinical signs of their heart disease when they are examined by a first opinion veterinary practitioner at the first veterinary health screening at about 6-8 weeks of age [1][2][3][4][5][6][7][8][9][10][11]. The presence of a cardiac murmur at the screening examination is often the only clue that a congenital cardiac anomaly might be present [1][2][3][4][5][6][7][8][9][10][11]. ...
... Most puppies with a congenital heart disease show no clinical signs of their heart disease when they are examined by a first opinion veterinary practitioner at the first veterinary health screening at about 6-8 weeks of age [1][2][3][4][5][6][7][8][9][10][11]. The presence of a cardiac murmur at the screening examination is often the only clue that a congenital cardiac anomaly might be present [1][2][3][4][5][6][7][8][9][10][11]. Although the prevalence of congenital cardiac anomalies in the general mixed breed canine population is very low [10], non-pathological cardiac murmurs are common findings in clinically healthy puppies at the age of about seven weeks (15-31%) [11][12][13]. ...
... Although the prevalence of congenital cardiac anomalies in the general mixed breed canine population is very low [10], non-pathological cardiac murmurs are common findings in clinically healthy puppies at the age of about seven weeks (15-31%) [11][12][13]. Differentiating pathological from non-pathological murmurs can be challenging, if not impossible, based on auscultation alone, especially in cases of soft systolic murmurs [1,11]. This initial differentiation is, however, crucial in deciding whether or not to recommend referral of a puppy with a suspected pathological murmur to a veterinary cardiology specialist, since congenital cardiac anomalies can be associated with high morbidity and mortality [2-5, 7-9, 14-16]. ...
Full-text available
Background Cardiac auscultation is an important screening test at the first health examination of puppies because most clinically relevant congenital cardiac anomalies cause a loud murmur from birth. This retrospective study aimed to investigate the age at which dogs with suspected congenital cardiac anomalies were referred to a veterinary cardiology specialist for murmur investigation. A secondary aim was to establish the time interval between the visit to the cardiologist and the first available murmur documentation. The digital archive of a veterinary teaching hospital was searched for dogs with congenital cardiac anomalies and puppies with innocent murmurs during a 5-year period. Dogs had to be referred because of a murmur, and they had to undergo physical examination and echocardiography by a veterinary cardiology specialist. The health certificate section of the pet passport, and the medical records from the referring veterinarian, were reviewed to identify the date when the murmur was first documented. Results Of the 271 included dogs, 94% had a congenital cardiac anomaly and 6% had an innocent murmur. The dogs’ median age was 190 days when they were examined by the cardiologist. Only 10% of the dogs were referred by the breeder’s veterinarian, while 90% of the dogs were referred by the new owner’s veterinarian. The median age of the first available murmur documentation by a first opinion veterinary practitioner was 95 days. Conclusions Only 10% of the puppies in the present study were referred to a veterinary cardiology specialist for murmur investigation before they were sold to a new owner. Referral prior to re-homing would have been feasible if the murmur had been detected and documented by the breeder’s veterinarian, if referral was offered by the breeder’s veterinarian and the referral was accepted by the breeder.
... The innocent murmur is a common physiological finding in puppies, generally as a result of physiologic anemia. Rising hematocrit in growing puppies can explain the spontaneous disappearance of innocent murmurs with aging [4]. ...
... Once the presence of a murmur has been identified, the aim for the veterinarian during the pre-purchase (clinical) examination is to determine the existence, severity, and exact origin of the underlying cardiac disease. Furthermore, the veterinarian should be required to perform the necessary diagnostic procedures such as echocardiography, which is considered the initial diagnostic test of choice and gold standard for identifying the cause of a cardiac murmur [4], and/or other tests (thoracic radiography, electrocardiography, etc.). ...
... This is strongly related to the blood velocity at the site of origin of the murmur and is classified as high, medium, or low. The murmurs that originate from mitral valve insufficiency typically have a high pitch [7], while the murmurs originating from aortic stenosis typically have a low or medium pitch [4,[8][9][10]]. The quality (or timbre) of the heart murmurs indicates the type of sound, which can be soft, harsh, rumbling, musical or a mixture of these. The shape, also referred to as configuration, indicates the intensity that it assumes during the cardiac cycle; therefore, a murmur may be crescendo, decrescendo, crescendo-decrescendo or plateau. ...
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The detection of a congenital heart defect at purchase is an important step in early detection from a clinical and legal standpoint. Indeed, some cardiac abnormalities may be corrected with surgery, and very often, treatment needs to be performed early before congestive heart failure or irreversible heart damage can occur. From a legal viewpoint, if the defect is revealed in a newly purchased puppy, the buyer may be required to return it and receive compensation. Puppies affected with congenital heart defects are likely to die prematurely, causing emotional suffering to the owner. Furthermore, by considering breed predisposition, early recognition allows breeders to avoid breeding from particular dogs with genetic defects and prevent the continuation of genetic defects in breeding lines. Given gaps in the literature about the recognition of murmurs in the puppy trade, the present article describes how to identify a heart murmur in a puppy during a pre-purchase examination and its significance from a clinical and legal viewpoint. In the canine population, the prevalence of cardiac defects ranges between 0.13 and 1.6%. Pulmonic stenosis is the most common defect found in puppies, followed by patent ductus arteriosus, subaortic stenosis, and ventricular septal defect. On the basis of the above considerations, the veterinarian should recognize and identify the murmur following a protocol for routine examination of puppies involved in trade.
... Innocent cardiac murmurs are common findings in clinically healthy puppies that are presented to first opinion veterinary practices for health checks at 6-7 weeks of age. 1 Contrary to most pathological murmurs, innocent murmurs tend to be soft, localized in the left heart base, limited to early systole, and become undetectable spontaneously as the puppy ages. [2][3][4] A recent study showed a marked difference in the prevalence of soft systolic murmurs in clinically healthy puppies when they were assessed by first opinion veterinary practitioners and, on aver-This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2021 The Authors. ...
... Once a murmur was detected, the following variables were noted: timing (systolic, diastolic or continuous), the point of maximal intensity (left or right heart base or apex) and intensity (scale 1-6), as well as other characteristics, such as beat-tobeat variability in intensity, and musical character. [1][2][3][4][5] Special attention was also made to auscultating the left axilla to detect potential left-to-right shunting patent ductus arteriosus. ...
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Background: Spontaneous week-to-week variation in the presence and intensity of innocent cardiac murmurs in individual puppies is unknown. Methods: Sixty privately owned, clinically healthy Cairn terrier and Dachshund puppies between 4 and 8 weeks of age were included. All dogs underwent weekly cardiac auscultation at the breeders' home by a veterinary cardiology specialist using an acoustic stethoscope. On each occasion, a phonocardiogram was recorded with an electronic stethoscope. Furthermore, all dogs were auscultated once at a first opinion veterinary practise and once at the authors' institution, where they also underwent an echocardiographic examination. Results: Two-hundred and eighty-one auscultations were conducted on 32 Cairn terriers and 28 Dachshunds, at the breeders' homes. Innocent murmurs were detected in 19 puppies. Two of these puppies had a detectable murmur on each auscultation. In five of the puppies, the murmur became undetectable during the observation period and in 12 puppies the murmur was intermittently audible. Auscultation at the authors' institution had an unpredictable effect on murmur presence and intensity. Phonocardiography revealed murmurs in 42 puppies. Interpretation of phonocardiograms by two independent observers showed nearly perfect agreement (κ = 0.859). Conclusions: Remarkable and unpredictable spontaneous week-to-week variation was documented in the presence and intensity of innocent murmurs.
... 3 type of CHD. Recognising defects with known inheritance patterns can influence breeding recommendations (Cote et al. 2015a, Brambilla et al. 2020. For example, a screening programme to identify PS and SAS in Boxers in Italy led to a gradual reduction in the prevalence of the defects in the breed over many years (Bussadori et al. 2009, Menegazzo et al. 2012, Brambilla et al. 2020. ...
... Therefore, a non-pathologic murmur would be considered unlikely if the murmur is loud, louder on the right side of the thorax compared to the left, diastolic, continuous, if other heart sounds are noted (i.e. arrhythmia or gallop), or if the animal has clinical signs or abnormal diagnostic test results (thoracic radiographs, cardiac biomarker) (Cote et al. 2015a,b, Marinus et al. 2017 (Fig 1). The presence of a soft, systolic left basilar murmur does not exclude CHD and can lead to delayed diagnosis of CHD in some animals if is incorrectly diagnosed as a non-pathologic murmur (Cote et al. 2015a,b). ...
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Congenital heart disease is an important subset of all cardiovascular disease in dogs and cats that is present at birth and most often detected in young animals but can be diagnosed in adulthood. The range of abnormalities that can occur during development of the heart is vast incorporating simple and complex defects, varying degrees of severity and clinical presentations that include heart failure and cyanosis. While some defects do not result in morbidity in an individual animal, others cause severe clinical signs and death at a young age. Advances in imaging and expanding treatment options offer increasingly more possibilities in the diagnosis and management of congenital heart disease which is the focus of this review. The objective is to provide a broad overview of current practice and highlight key aspects to guide practitioners in their approach to congenital heart disease diagnosis and knowledge of available treatment options.
... As manifestações clínicas mais comuns de pacientes cardiopatas consistem em sopros, sons de galope e dispneia (Duler et al, 2019). Contudo, o sopro pode ser auscultado em gatos saudáveis, sendo considerados funcionais, e não relacionados a uma alteração cardíaca em si (Coté et al., 2015). Da mesma forma, gatos podem apresentar-se assintomáticos ao longo da vida e desenvolver o quadro de morte súbita Fox et al, 2018). ...
... Em relação aos sinais clínicos, os gatos que participaram do estudo apresentaram, em sua maioria, manifestações prévias condizentes com o relatado para pacientes cardiopatas (Nakamura et al., 2011;Coté et al., 2015;Duler et al, 2019). Casos mais graves estadiados em C e D, apresentaram insuficiência cardíaca congestiva e, consequentemente, tiveram reflexos negativos na sobrevida. ...
... It has been suggested that when advanced cardiac disease is missed before general anaesthesia or intravenous fluid therapy, unforeseen signs of congestive heart failure are likely to occur (Côté et al. 2015). The most common modifications in the AP in dogs with an audible cardiac murmur were administration of acepromazine instead of medetomidine or a reduction in medetomidine dose in the premedication phase. ...
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Objectives Identify whether pre‐anaesthetic clinical examination influences anaesthetic and analgesic agents and techniques protocol in dogs presented for general anaesthesia and sedation at a large referral hospital. Materials and Methods In this prospective clinical audit, 554 dogs, undergoing general anaesthesia or sedation for surgical, diagnostic or imaging procedures were included. Multiple attending anaesthetists completed a questionnaire divided into four sections (American Society of Anesthesiologists physical status classification, anaesthetic and analgesic agents and techniques protocol, pre‐anaesthetic clinical examination findings and changes made to the anaesthetic protocol). The attending anaesthetist was able to review the patient's history before planning the anaesthetic and analgesic agents and techniques protocol. The patients were examined and changes in American Society of Anesthesiologists physical status classification or anaesthetic protocol were recorded. Results The initial anaesthetic and analgesic agents and techniques protocol was altered in 23.3% (n=129/554) of cases following a pre‐anaesthetic clinical examination, but American Society of Anesthesiologists physical status reclassification occurred in only 8.0% (n=37/464) of cases. Multivariable logistic regression analysis showed that pre‐anaesthetic clinical examination performed by European College of Veterinary Anaesthesia and Analgesia diplomates (odds ratio 5.8, 95% confidence interval 2.0 to 17.2), compared to anaesthesia interns, and the presence of an audible heart murmur (odds ratio 2.4, 95% confidence interval 1.4 to 4.4) were factors linked to changes in anaesthetic and analgesic agents and techniques protocol, whereas for each one kilogram increase in patient's weight, the odds of a change in anaesthetic and analgesic agents and techniques protocol to occur decreased by 1.7% (odds ratio 0.98, 95% confidence interval 0.97 to 1.0). Clinical Significance Pre‐anaesthetic clinical examination has impact on American Society of Anesthesiologists physical status classification, therefore estimation of patient's anaesthetic risk, and influences anaesthetic and analgesic agents and techniques protocol choice.
... 12 A thorough cardiac auscultation is an essential part of a complete clinical exam, and accurate identification of abnormal heart sounds may aid recognition of underlying heart disease. 13,14 Annual auscultation is cited as an important monitoring tool in the ACVIM consensus statement on guidelines for the diagnosis and treatment of canine myxomatous mitral valve disease. 15 This recommendation is based on the assumption that the veterinary surgeon performing the clinical examination can adequately identify and classify the murmur. ...
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Background: Cardiac auscultation is an important part of the physical examination. This study evaluated cardiac auscultation skills in veterinary students and compared their abilities to recent veterinary graduates, referral hospital veterinary surgeons and veterinary cardiologists or cardiology residents. In addition it compared their self-predicted quiz scores to their actual scores, evaluating if they could accurately predict their own performance level. Methods: A digital recording device was used to record auscultation sounds from 12 different patients with a diagnosis confirmed by a board-certified veterinary cardiologist. The sound files and associated phonocardiograms were uploaded to a video sharing website. A cloud-based online multiple-choice quiz was generated and shared with final year veterinary students, recent veterinary graduates, referral hospital veterinary surgeons and veterinary cardiologists or cardiology residents. Results: There were 128 participants: 51 final year veterinary students, 62 recent veterinary graduates, and 10 referral hospital veterinary surgeons and five veterinary cardiologists or cardiology residents. No difference was found between the cardiac auscultation skills of recent veterinary graduates and final year veterinary students. Veterinary students' self-predicted scores were lower than actual scores. Conclusions: Recent veterinary graduates did not perform better than final year veterinary students in this study, suggesting that auscultation skills do not continue to improve in the first few years after graduation. Efforts should be made to maximise students' learning in cardiac auscultation skills. Veterinary students show a lack of confidence in cardiac auscultation skills.
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Background: Feline lower urinary tract disease (FLUTD) is a common disorder associated with the dysfunction of the urinary bladder or urethra in tomcats. Aim: A prospective study was carried out on the point prevalence and odds ratio (OR) of the FLUTD in Shirazi and Baladi tomcats at Ismailia Governorate, Egypt, recording the prominent clinical manifestation and identifying the antibiogram, virulence, and antimicrobial resistance genes of the causative microorganisms. Methods: A total number of 420 tomcats admitted to the veterinary clinics of Ismailia during the period June 2020 to May 2021 were examined for FLUTD. A total of 1,260 urine samples were collected and analyzed. Results: Hematuria, dysuria, and pollakiuria were the most evident signs recorded in a total of 120 tomcats diagnosed with FLUTD. The diagnosed cases of FLUTD were associated with causes like crystals (35.83%), pyogenic microorganisms (19.16%), and mixed cases (45.00%). The prevalence revealed highly significant (p < 0.01) increases in the cases caused by Escherichia coli, E. coli mixed cases, and calcium oxalate at >4 years; Staphylococcus aureus at ≤ 2 years; amorphous urate and phosphate at 2-4 and >4 years in Shirazi and ≤2 years in Baladi; triple phosphate at ≤2 years in Shirazi and >4 years in Baladi; and S. aureus mixed cases at ≤2 years. The OR of FLUTD revealed higher odds of associations with E. coli, E. coli mixed cases, S. aureus, amorphous urate, and triple phosphate, as well as lower odds with S. aureus, calcium oxalate, amorphous phosphate, and S. aureus mixed cases. Isolated E. coli revealed higher resistance to amoxicillin (AMX, 83.4%), ceftriaxone (83.4%), ceftazidime (CAZ, 75.0%), and cefoxitin (FOX, 50.0%), and S. aureus to oxacillin (100%), FOX (100%), AMX (85.8%), CAZ (76.2%), and FOX (50.0%). S. aureus-detected virulence genes were mecA, coa, spa, and tetK, and E. coli were fimH, iss, iutA, papC, blaTEM, blaCTX-M, and tetA. About 100% of E. coli and 76.1% of S. aureus isolates exhibited multidrug resistance. Conclusion: FLUTD in tomcats is associated with higher odds in E. coli, E. coli mixed cases, and triple phosphate at older ages (>4 years) with high antimicrobial resistance in the microbial isolates contributing to the disease.
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Left atrial (LA) enlargement, congestive heart failure (CHF), and aortic thromboembolism (ATE) are associated with decreased survival in cats with hypertrophic cardiomyopathy (HCM), but the prognostic value of echocardiographic variables has not been well characterized. We hypothesized that LA echocardiographic variables and assessment of left ventricular (LV) diastolic and systolic function would have prognostic value in cats with HCM. Two hundred eighty-two cats diagnosed with HCM. Clinical and echocardiographic records of affected cats seen at the Royal Veterinary College from 2004 to 2009 were retrospectively analyzed. Only cats with echocardiographic confirmation of LV diastolic wall thickness ≥6 mm were included. Outcomes were obtained from clinical records or referring veterinarians and owners. Deaths occurred in 164 cats, of which 107 were believed to have been cardiac deaths. Univariable predictors of an increased risk of cardiac death included older age, absence of a murmur, presence of a gallop sound or arrhythmia, presentation with either CHF or ATE, extreme LV hypertrophy (≥9.0 mm), LV fractional shortening (FS%) ≤30%, regional wall hypokinesis, increased left atrial size, decreased left atrial function, spontaneous echo-contrast/thrombus or both, absence of left ventricular outflow tract obstruction, and a restrictive diastolic filling pattern. Cox's proportional hazard analysis identified LA dysfunction, low LV systolic function, and extreme LV hypertrophy as independent predictors of decreased cardiac survival time. Echocardiographic measurement of LA function, extreme LV hypertrophy, and LV systolic function provides important prognostic information in cats with HCM.
Published information regarding survival and long-term cardiac remodeling after patent ductus arteriosus (PDA) closure in dogs is limited. To report outcome and identify prognostic variables in dogs with PDA, and to identify risk factors for persistent remodeling in dogs with a minimum of 12 months of follow-up after closure. Five hundred and twenty client-owned dogs. Retrospective review of medical records of 520 dogs with PDA. Outcome was determined by contacting owners and veterinarians. Dogs with PDA closure and ≥ 12 months of follow-up were asked to return for a re-evaluation. In multivariable analysis of 506 dogs not euthanized at the time of diagnosis, not having a PDA closure procedure negatively affected survival (HzR = 16.9, P < .001). In 444 dogs undergoing successful PDA closure, clinical signs at presentation (HzR = 17, P = .02), concurrent congenital heart disease (HD) (HzR = 4.8, P = .038), and severe mitral regurgitation (MR) documented within 24 hours of closure (HzR = 4.5, P = .028) negatively affected survival. Seventy-one dogs with ≥ 12 months follow-up demonstrated a significant reduction in radiographic and echocardiographic measures of heart size (P = 0) and increased incidence of acquired HD (P = .001) at re-evaluation. Dogs with increased left ventricular size and low fractional shortening at baseline were more likely to have persistent remodeling at re-evaluation. Patent ductus arteriosus closure confers important survival benefits and results in long-term reverse remodeling in most dogs. Clinical signs at presentation, concurrent congenital HD, and severe MR negatively affect survival. Increased left ventricular systolic dimensions and systolic dysfunction at baseline correlated significantly with persistent remodeling.
To determine whether a training course in focused echocardiography can improve the proficiency of noncardiology house officers in accurately interpreting cardiovascular disease and echocardiography findings in dogs entering the emergency room setting. Prospective, blinded, educational study. University veterinary teaching hospital. House officers underwent training in focused echocardiography. Fifteen dogs, including normal dogs and dogs with stable congenital or acquired cardiac disease, were used as study subjects during the laboratory session. A 6-hour curriculum on focused echocardiography was developed that included didactic lectures, clinical cases, and hands-on echocardiography. Pre- and postcourse written examinations were administered to participants. House officers attended didactic lectures that were subsequently followed by a hands-on laboratory session and practical examination, which involved performing transthoracic echocardiography on dogs with and without cardiovascular disease. Twenty-one house officers completed the focused echocardiography training course. Written examination scores were 57 ± 12% before and 75 ± 10% after training (P < 0.001). Following the course, 97% of participants in the practical examination were able to obtain the correct right parasternal short- or long-axis view. Posttraining, most participants correctly identified pleural effusion (90%) and pericardial effusion (95%) and discriminated normal atrial size from atrial enlargement (86%). However, successful identification of a cardiac mass, volume status, and ability to recognize a poor quality study as nondiagnostic remained relatively low. Most trainees responded that the length of hands-on laboratory training was too abbreviated and that the course should be > 6 hours. A focused echocardiography training course improved knowledge and yielded acceptable proficiency in some echocardiographic findings commonly identified in the emergency room. This training course was not able to provide the skills needed for house officers to accurately assess fluid volume status, identify cardiac masses, ventricular enlargement or hypertrophy, and certain cardiac diseases.
Objective: To assess the effectiveness of the vertebral heart scale (VHS) system to differentiate congestive heart failure from other causes of dyspnea in cats. Design: Retrospective case series. Animals: 67 cats with acute respiratory distress. Procedures: Medical records of client-owned cats evaluated on an emergency basis because of acute respiratory distress during a 1-year period were reviewed. For study inclusion, cats must have undergone evaluation with echocardiography and thoracic radiography within 12 hours after hospital admission. The VHS was calculated for each cat by 2 investigators. Signalment, physical examination, and echocardiographic findings were reviewed for each patient. Results: There was 83% agreement overall between the 2 investigators in assessment of cardiomegaly in cats with dyspnea (κ = 0.49). The VHS cutpoints were the same for both observers in terms of optimizing sensitivity and specificity. A VHS of > 8.0 vertebrae was the best cutpoint when screening for heart disease, whereas a VHS of > 9.3 vertebrae was very specific for the presence of heart disease. Measurements between 8.0 and 9.3 vertebrae suggested the cause of dyspnea was equivocal (ie, secondary to congestive heart failure or respiratory disease), in which case echocardiography would be most useful in providing additional diagnostic information. Conclusions and clinical relevance: Results suggested that the VHS system may be a useful tool to help differentiate cardiac from noncardiac causes of respiratory distress in cats in an emergency situation when an echocardiogram is not available or is not plausible in an unstable patient.