Anti-inflammatory effects of Allium Sativum (Garlic) in experimental rats
Background and Objectives: Non-steroid anti-inflammatory drugs (NSAIDs) are known to cause adverse effects. On the other hand, garlic is believed to have hypolipidaemic, antibacterial, anti-rheumatic and anti-inflammatory properties. Hence present study was undertaken to know the Anti-inflammatory effect of allium sativum in Albino Rats. Materials and Methods: A total of 36 rats were randomized into two groups of 18 each to be utilized by acute (Carrageenin induced paw edema) and chronic (Cotton pellet induced granuloma) inflammatory models. Further within each group the animals were randomly allocated to the control, standard (Piroxicam) and test (Garlic) drug groups. The rats were fed respective drugs orally 1 hour prior to experimentation. Reduction in paw edema size was recorded at four hours and in dry granuloma weight on 8th day after sacrificing the animal. To compare the reductions among three groups, one-way ANOVA was performed. Results: The effect of the test drug in terms of percent inhibition was found to be about 50% in acute and 21% in chronic models. Also, the acute effect was similar to standard drug. Conclusion: In view of the side effects of NSAIDs and corticosteroids, it may be envisaged that garlic can be used as an adjuvant in the inflammatory disorders.