ArticlePDF Available

A Review on Giloy: The Magic Herb

Authors:
  • Amity University Lucknow

Abstract

INTRODUCTION Tinospora Cordifolia is a climbing shrub belongs to family Menispermaceae. It is commonly known as Guduchi, Amrita, Gurach, Tinospora. It is a large, glabrous deciduous climbing shrub. The stems are rather succulent with long filiform fleshy aerial roots form the branches. The bark is gray brown and watery. The leaves are membranous and cordate. The flowers small and greenish yellow. This herb is found throughout tropical asia ascending to a height of 300 mts.
A preview of the PDF is not available
... The reduction in eosinophil count, stimulation of B lymphocytes, macrophages, haemoglobin level, and polymorphonuclear leukocytes revealed this anti-HIV impact (Mittal et al., 2014) [33] . (Sarangi et al., 2013) [45] stated that people with HIV and other autoimmune disorders profit from Giloy. The conventional use of Giloy as an immune stimulant prompted researchers to investigate its effects on HIV patients. ...
... The reduction in eosinophil count, stimulation of B lymphocytes, macrophages, haemoglobin level, and polymorphonuclear leukocytes revealed this anti-HIV impact (Mittal et al., 2014) [33] . (Sarangi et al., 2013) [45] stated that people with HIV and other autoimmune disorders profit from Giloy. The conventional use of Giloy as an immune stimulant prompted researchers to investigate its effects on HIV patients. ...
Article
This review provides an overview of Tinospora cordifolia's morphology, pharmacological profile, and health benefits, along with its ethnobotanical usage, value-added products, and market product availability. The plant is extensively used in traditional Ayurvedic medicine for treating jaundice, rheumatism, urinary disorders, skin illnesses, diabetes, anaemia, inflammation, allergic conditions, anti-periodic, radioprotective qualities, and so on. It exhibits various therapeutic properties in treating metabolic problems as well as its potential as an immune booster, which has given it a considerable amount of scientific attention. It is worth using because it is quite efficient against a range of infections and is very economical.
Article
Full-text available
The oral administration of various extracts (hexane, ethyl acetate and methanol) of Tinospora cordifolia stem (TCS) were found to have potent antidiabetic activity that reduces blood sugar level in streptozotocin-(STZ) induced diabetic rats. In this study, the chronic (100 days) antihyperglycemic effect of the extracts at a dose of 250 mg/kg b.w.p.d of TCS were investigated. Insulin was used as a reference drug at a dose of 3 I.U/kg.b.w.p.d. Fasting blood glucose, glycosylated hemoglobin (HBA 1 C), serum insulin, C-peptide and liver enzymes levels were evaluated in normal, diabetic and treated rats. Supplementation of methanol extract significantly reduces the fasting blood glucose level when compared to other 2 extracts. Moreover this supplementation significantly decreases the glycosylated hemoglobin level as compare to diabetic control (p < 0.001), reduced glucokinase and increased glucose-6-phoaphatase activity were reversed significantly by the treatment of TCS methanol extract in respect to diabetic group. In the TCS treated groups, the insulin and C-peptide levels were improved which shows the regeneration of -cell which secretes insulin, histopathological studies of pancreas of TCS methanol extract treated groups substantiate the regenerating capacity of extract.
Article
Full-text available
To evaluate antidiabetic activity of chloroform extracts of Acacia arabica bark, Benincasa hispida fruit, Tinispora cordifolia stem, Ocimum sanctum areal parts and Jatropha curcus leaves. The chloroform extracts of Acacia arabica bark, Benincasa hispida fruit, Tinospora cordifolia stem, aerial part of Ocimum sanctum and Jatropha curcus leaves were evaluated at different doses (250 and 500 mg/kg body weight.) for antidiabetic potentials in alloxan induced diabetic albino rats. The extracts were administered for two weeks in different groups whereas tolbutamide (80 mg/kg body weight) was used as reference standard throughout study. The result of present study showed test compounds significantly decreases elevated level of serum glucose and also caused to reverse the cholesterol, triglyceride, HDL and LDL values when compared to untreated diabetic rats. Our finding indicates that different test extracts were able to ameliorate the derangements in lipid metabolism caused by diabetes mellitus in alloxan induced diabetic rats towards normal level.
Article
Full-text available
The primary objective of this investigation is to determine the deleterious effects of sub lethal gamma radiation on testes and their possible inhibition by Tinospora cordifolia extract (TCE). For this purpose, one group of male Swiss albino mice was exposed to 7.5 Gy gamma radiation to serve as the irradiated control, while the other group received TCE (75 mg/kg b. wt./day) orally for 5 consecutive days half an hr before irradiation to serve as experimental. Exposure of animals to 7.5 Gy gamma radiation resulted into significant decrease in body weight, tissue weight, testes- body weight ratio and tubular diameter up to 15 days of irradiation. Cent percent mortality was recorded by day 17th in irradiated control, whereas all animals survived in experimental group. TCE pretreatment rendered significant increase in body weight, tissue weight, testes- body weight ratio and tubular diameter at various intervals as compared to irradiated group. Radiation induced histological lesions in testicular architecture were observed more severe in irradiated control then the experimental. TCE administration before irradiation significantly ameliorated radiation induced elevation in lipid peroxidation and decline in glutathione concentration in testes. These observations indicate the radio- protective potential of Tinospora cordifolia root extract in testicular constituents against gamma irradiation in mice.
Article
Efficacy of Tinospora cordifolia (Willd.) stem extracts (both aqueous and alcoholic) in differ- ent dosages (200 and 400 mg/ kg b.w) on blood lipid profile in streptozotocin induced dia- betic albino rats was investigated in this study. The drug was admi nistered orally for 10 days in 24 rats of 4 different groups treated with Tinospora cordifolia . Similarly, in another group of study consisting of 24 rats, the drug was administered orally for 30 days. Efficacy of Tinospora cordifolia in ameliorating the metabolic derangements in lipid metabolism caused by diabetes was compared with the Lante Zinc Insulin (6 Units / kg b.w. daily. i.p.) treated diabetic rats. Plasma total cholestero l, triglycerides, free fatty acids, phospholipids and lipoproteins like high density lipoprotein, low density lipoprotein and very low density lipoprotein -cholesterol levels were measured according to th e standard biochemical meth- ods. Drug treated diabetic animals sh owed a significant (p< 0.05) effect of Tinospora cordifo- lia on all these parameters compared to untrea ted animals. Treatment with insulin restored all these altered parameters to near normal leve ls in diabetic animals. Our results indicated that Tinospora cordifolia stem extract is able to ameliora te the derangements in lipid me- tabolism caused by diabetes mellitus in strepto zotocin induced diabetic rats towards normal level. Hence, this study may reveal the usef ulness and beneficial va lue of herbal drug Tino- spora cordifolia in treating hyperlipidemia. Keywords: Tinospora cordifolia , Diabetes mellitus, Streptozotocin, Meta bolic derangements, Hyperlipidemia
Article
The antidiabetic effects of hydroalcohiolic extracts of Acacia Arabica, Benincasa hispida , Tinispora cordifolia and Ocimum sanctum were investigated in diabetic rats. The Alloxan monohydrate was used to induce the diabetes in normal rats. The tolbutamide 80 mg/kg p.o. was used the standard antidiabetic throughout the study. Our results indicated that 250 and 500 mg/kg b.w. of all hydroalcoholic test extracts reversed the altered glucose, cholesterol, triglycerides, LDL and HDL levels in diabetic rats significantly and in dose dependent manner. Hence, the study reveals the usefulness and beneficial value of herbal drugs in the treatment of diabetes.
Article
The ethanol extracts of the roots of T. cordifolia Miers and C. asiatica Linn were observed to induce a marked protective action against an 8 h restraint stress induced ulcerization, the activity being comparable to that of diazepam.
Article
T. cordifolia (Guduchi) is a large, glabrous, perennial, deciduous, climbing shrub of weak and fleshy stem found throughout India. It is a widely used plant in folk and Ayurvedic systems of medicine. The chemical constituents reported from this shrub belong to different classes, such as alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoid, phenolics, aliphatic compounds and polysaccharides. Various properties of T. cordifolia, described in ancient texts of Ayurveda, like Rasayana, Sangrahi, Balya, Agnideepana, Tridoshshamaka, Dahnashaka, Mehnashaka, Kasa-swasahara, Pandunashaka, Kamla-Kushta-Vataraktanashaka, Jwarhara, Krimihara, Prameha, Arshnashaka, Kricch-Hridroganashak, etc., are acquiring scientific validity through modern research adopting "reverse pharmacological" approach. Potential medicinal properties reported by scientific research include anti-diabetic, antipyretic, antispasmodic, anti-inflammatory, anti-arthritic, antioxidant, anti-allergic, anti-stress, anti-leprotic, antimalarial, hepato-protective, immuno-modulatory and anti-neoplastic activities. This review brings together various properties and medicinal uses of T. cordifolia described in Ayurveda, along with phytochemical and pharmacological reports.
Article
To assess the safety and efficacy of TCE in human immuno-deficiency virus positive patients. Efficacy of Tinospora cordifolia extract (TCE) in HIV positive patients was assessed in randomized double blind placebo controlled trial. 68 HIV positive participants were randomly assigned to two groups to receive either TCE or placebo for six months. After clinical examination TLC, DLC, ESR, platelet count, hemoglobin and CD4 count were done. The hematological investigations were repeated at bimonthly intervals and CD4 count was repeated at the end of the study. Patients were clinically reviewed at monthly intervals for compliance, refill and ADR monitoring. The drugs were decoded at the end of the trial. TCE treatment caused significant reduction in eosinophil count and hemoglobin percentage. 60% patients receiving TCE and 20% on placebo reported decrease in the incidence of various symptoms associated with disease. Some of the common complaints reported by patients on TCE were anorexia, nausea, vomiting and weakness. Tinospora cordifolia extract, a plant derived immunostimulant, significantly affected the symptoms of HIV. This was validated by clinical evaluation. However not all of the objective parameters studied by us, back this up. Tinospora cordifolia could be used as an adjunct to HIV/AIDS management.