Intellectual property rights protection is at the forefront of some of the major controversies regarding the impact of globalization. African countries have in recent years participated to an unprecedented degree in both international and bilateral initiatives dealing with intellectual property. The negotiating positions have been varied and, from a regional perspective, have not been coherent at some levels, with different countries advancing different positions. African countries have adopted regional integration as a strategy to deal with the challenges of globalization. Regional integration is believed to increase negotiating capacities and competitiveness in global trade. It is also believed to improve access to foreign technology. The African Union is facilitating the establishment of a continental intellectual property body. Accordingly, the main aim of this article is to discuss the establishment of the Pan-African Intellectual Property Organization in line with the African Union's vision for regional integration.