Long-term Outcomes of Toddlers With Autism Spectrum Disorders Exposed to Short-term Intervention

ArticleinPediatrics 130(Supplement):S186-S190 · November 2012with3 Reads
DOI: 10.1542/peds.2012-0900Q
Objectives: To examine long-term outcomes of toddlers with autism spectrum disorder (ASD) who received a 6-month early intervention at age 2. Methods: Forty-eight toddlers diagnosed with an ASD received a 6-month evidence-based intervention. Cognitive (IQ) and communication ability, as well as severity of autism symptoms, were assessed by using standardized measures at preintervention (Time 1 [T1]; mean [M] age = 27 months), postintervention (T2; M age = 35 months), short-term follow-up (T3; M age = 41 months), and long-term follow-up (T4; M age = 72 months). Results: From pre- to postintervention, significant gains in IQ and Vineland Communication domain standard scores as well as a reduction in ASD severity were achieved (all P < .01). Between T2 and T3, the 6-month period immediately after completion of the intervention, IQ and Communication scores stabilized and ASD severity increased significantly (P < .05). During the long-term follow-up period (T3-T4), IQ and Communication scores significantly increased again, but ASD severity increased significantly as well (all P < .05). For overall trajectory (T1-T4), robust gains were observed for both IQ and communication; ASD severity did not change. Conclusions: Findings highlight the potential for positive long-term outcomes in toddlers with ASD. Additional research is needed to understand the relation between early exposure to uninterrupted intervention and developmental gains, and whether initial reduction in ASD symptom severity can be sustained through targeted intervention.
    • "Moderate benefits were reported for IQ, language, joint attention and anxiety however the strength of the findings was weak (Keen et al. 2010; Dawson et al. 2010 Dawson et al. , 2012 Fava et al. 2011; Aldred et al. 2012; Strauss et al. 2012; Landa et al. 2011 Landa et al. , 2012 Roberts et al. 2011; Peters-Scheffer et al. 2013; Schreibman et al. 2014). Some studies reported positive outcomes for both social skills (Koenig et al. 2010; Williams et al. 2012) and play-based interventions (Goods et al. 2013; Kasari et al. 2010; Ingersoll 2010a Ingersoll , 2010b ). "
    [Show description] [Hide description] DESCRIPTION: Draft MS (part 2) discussing UK ASD research and implications of DSM5, RDoC and the IACC
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    • "Early intervention is a key prognostic indicator of more positive outcomes in youth with ASD (Corsello 2005; Itzchak and Zachor 2011; Woods and Wetherby 2003). Although various early intervention programs currently exist and comparative efficacy research is mixed, reported positive outcomes include gains in cognitive functioning (Landa and Kalb 2012; Sallows and Graupner 2005), communication (Landa and Kalb 2012; Woods and Wetherby 2003), adaptive behavior (Eikeseth et al. 2012; Reichow 2012), and fewer social problems and problem behaviors (Eikeseth et al. 2007). "
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    • "The current professional consensus is that early diagnosis and subsequent early treatment of autism spectrum disorder (ASD) can facilitate development and learning [1, 2], reduce the need for treatment later in life [3, 4], and improve longterm prognosis in adulthood [5, 6]. However, not all families with children with ASD necessarily get timely access to treatment and other support. "
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