This chapter reviews the literature on work–family interventions focusing on linkages to evidence-based employee health and well-being outcomes and on return on investment (ROI) in organizations. Work–family interventions include, but are not limited to, alternative work arrangements, family supportive supervisor behavior training, work redesign to increase schedule control, and the provision of ... [Show full abstract] dependent care supports. Work–family interventions have the goal of reducing work–family conflict and in turn increasing the health and well-being of employees and the organizations in which they work (Kossek, Hammer, Kelly, and Moen, 2014). Sixteen studies were identified that meet our criteria. The chapter provides a discussion of establishing the work–family intervention value proposition with a focus on ROI, concluding with a discussion of approaches and guidelines for future work–family intervention research and practice.