... Various isolated flavonoids have found to reversed reduced level of BDNF and shown anti-depressant action by increasing BDNF expression [1,30,145]. These flavonoids include hesperidine, apigenin, astilbin, baicalein, chrysin, dihydromyricetin, hyperoside, icariin, 7,8 dihydroxyflavone, myricetin, naringenin, naringenin, orientin, silibinin and 3,5,6,7,8,3′,4′-heptamethoxyflavone, etc. [1,41,49,54,55,60,61,68,80,87,92,94,104,122,128,136,137]. In pre-clinical studies, these flavonoids increased hippocampal BDNF level, modulate neuronal network, maintain neuronal plasticity and regulate neurogenesis, neuronal maturation and synaptogenesis in rodent brain [214][215][216]. ...