This paper presents a study of aircraft featuring truss-braced wing configurations that have been optimized for minimum fuel consumption using multidisciplinary design optimization. The investigation proceeds following an earlier Boeing SUGAR N+3 study, which selected the truss-braced wing concept as the most promising of several N+3 concept vehicles. This comes from the fact that a significantly higher aspect ratio wing could achieve substantial reductions in induced drag, but requires major structural changes to support such a large span. This problem was explored through the use of a multi-disciplinary design and analysis environment implemented in ModelCenter. Optimization was performed using ModelCenter’s Design Explorer and Darwin genetic algorithm optimizers. Using the multidisciplinary environment, a large multi-dimensional design space featuring design variables spread across the major aircraft design disciplines was explored. Configurations featuring a strut-braced wing, and truss-braced wings with one and two juries were evaluated for different span limits. Subsequently, different laminar wing design options were investigated in conjunction with lift augmentation system options. The multidisciplinary optimization used for this investigation was able to produce candidate designs with the desired attributes and performance improvements, while satisfying all relevant geometric and performance constraints.