While suicidologists have interpreted the motives and risk factors of suicide in numerous ways, the ultimate objective is to find a theory that explains the majority of the variance in suicidal behaviors. Durkheim's (1951 ) classical theory of social integration and regulation, explaining egoistic, altruistic, anomic and fatalistic suicide, is in theoretical and practical conflict with the psychopathological theories prevalent in today's world. However, substantial numbers of suicides, East and West, are carried out by individuals who appear to be socially integrated (Zhang, 2000; Zhang & Jin, 1998), and only a very small percentage of mentally ill people kill themselves (Mann, et al., 1999), although over 90% of suicides in the West have been diagnosed with mental disorders including major depression and alcohol or substance use disorders (NIMH, 2003). Also, in the Western world, individuals who are male, white or older are more likely to kill themselves than individuals who are female, black or younger. If the psychiatric model were valid, men, whites and older persons should be more abnormal psychologically than women, blacks and younger persons which is, of course, far from the truth (Thio, 2004). A psychiatric disorder may be a necessary condition for suicide, but it is definitely not sufficient, and in order to identify suicide risk factors, it is necessary to look beyond the presence of a major psychiatric syndrome (Mann, et al., 1999). Furthermore, most previous studies of suicide have been restricted to one domain of possible risk factors such as the social (Brent, et al., 1993; Chiles, et al., 1989; Daly, et al., 1986; Maris, 1997; Roy, 1985; Roy & Segal, 1995; Schulsinger & Kety, 1979; Zhang & Thomas, 1991), psychiatric (Kaplan & Harrow, 1996; Rich & Runeson, 1995; Strakowski, et al., 1996), or psychological (Beck, et al, 1985; Nordstrom, et al., 1995; Pokorny, 1983; Zhang & Jin, 1998). Most of those studies are generally from medical perspectives and are exploratory in nature. Mann and colleagues (1999) developed and tested a stress-diathesis theory of suicide, but it is only a clinical model based on and for psychiatric patients. Heeringen's (2003) psychobiological model of suicidal behavior that focuses on a state-trait interaction seems more generalizable, but again is neurobiological in nature. In order to overcoming these deficiencies, this chapter proposes a basic paradigm that incorporates the available theories, hypotheses and findings explaining suicide in the world today. The new paradigm is built on previous notions of anomie and strain (Durkheim 1951 ), although Merton's (1957) strain theory of deviance and crime and Agnew's (1992) general strain theory have not in the past included suicide as a target for explanation.