In preparing the treatment of the Orchidaceae for the Flora of the Venezuelan Guayana, several new taxa have been detected. These include specimens from recently completed expeditions and earlier herbarium material. Reconsideration of generic boundaries within several subtribes has made necessary various nomenclatural changes. The following new taxa and combinations are proposed: Cleistes huberi, sp. nov.; C. rosea f. pallida, f. nov.; C. unifoliata, comb. nov.; Octomeria romerorum, sp. nov.; Pleurothallis deborana, sp. nov.; P. pemonum, sp. nov.; Stelis garayi, comb. nov.; Sobralia oliva-estevae, sp. nov. In addition, comments are supplied, where pertinent, on the affinities of the various taxa proposed.