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Hypoglycemic Effect of Hazelnut and its Effect on Some Sex Hormones in Alloxan Induced Diabetic in Female Rats

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Hazelnut is the second richest source of monounsaturated fatty acids among nuts and is rich in vitamins E and B6, phytosterols, folate, L-arginine, polyphenols and fiber. The present study aimed to investigate the hypoglycemic effect of hazelnut and its effect on some sex hormones in diabetic female rats. Animals were randomly assigned to five groups of equal number and weight. Group I, kept as a normal control group; Group II, kept as a diabetic control group, Groups III, IV and V, kept as diabetic groups and feeding supplemented diet with 5, 10 and 15% hazelnuts, respectively. Supplemented diet with 10% and 15% of hazelnut significantly lower food intake compare to the positive control group. Body weight gain significantly increased in treated diabetic group compare with the positive control group. Feeding supplemented diet with hazelnut at the three different levels caused significantly lower in concentrations of blood glucose, total lipids, triglycerides, total cholesterol, AST, ALT, blood urea nitrogen, uric acid and creatinine and significantly lower in levels of insulin, thyroid stimulating, follicle-stimulating and luteinizing hormones compared to that of untreated diabetic rats. Histological study showed hypertrophy and hyperplasia in beta-cells of islets of langerhans associated with pyknosis of their nuclei in positive control rats. Slight hypertrophy in islets of langerhans and congestion of pancreatic blood vessel was showed in pancreas sections of treated rats with 5 and 10% of hazelnut, respectively. However, rats treated with 15% of hazelnut showed apparent normal histological structure. Ovary sections of positive control rats showed dilation and congestion of blood vessel as well as interstitial connective tissue proliferation. Interstitial cells hyperplasia and follicles were showed in ovary of treated rats with 5 and 10% of hazelnut, respectively. Primary oocytes were showed in ovary sections of treated rats with 15% of hazelnut. In conclusions, hazelnut can be readily incorporated into healthy diet to its healthy effect benefits in diabetes and its complication.
... In another study using hamsters no significant in weight was observed throughout the experimental period (Caimari et al., 2015). However in a recent study Abeer and Amr (2013) examined the effect of dietary supplementation with hazelnut on food intake and body weight in a rat model of diabetes and reported that hazelnut-enriched diet caused a dose-related decrease in food intake and a significant decrease in body weight gain compared to rodents fed A. Mollica et al. Journal of Functional Foods 47 (2018) 562-574 normal diet. ...
... In this study the consumption of Italian hazelnut enriched diet resulted in a dose-related (0.5, 1%) increase in blood glucose levels compared to mice fed normal diet or HFD; while Turkish hazelnut-enriched diet had a normoglycaemic effect. These results corroborates a few studies in humans reporting that supplementation with hazelnut diet did not significantly alter blood glucose levels (Lima et al., 2017;Perna et al., 2016), although Abeer and Amr (2013) reported a hypoglycaemic effect of hazelnut-enriched diet in rats. Hazel-enriched diet mitigated also against HFD-induced alteration in liver weight, biochemistry and morphology as well as omental fat weight and morphometry (Turkish hazelnut), this corroborates the result of the study by Abeer and Amr (2013) that also reported similar effects albeit in diabetic rats. ...
... These results corroborates a few studies in humans reporting that supplementation with hazelnut diet did not significantly alter blood glucose levels (Lima et al., 2017;Perna et al., 2016), although Abeer and Amr (2013) reported a hypoglycaemic effect of hazelnut-enriched diet in rats. Hazel-enriched diet mitigated also against HFD-induced alteration in liver weight, biochemistry and morphology as well as omental fat weight and morphometry (Turkish hazelnut), this corroborates the result of the study by Abeer and Amr (2013) that also reported similar effects albeit in diabetic rats. ...
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In this study, the nutraceutical potential of two hazelnut varieties (Turkey and Italy) were examined by studying several aspects including the phytochemical properties, antioxidant potential, cell viability and ex vivo neuroprotective potential. Results showed that the Turkish hazelnut had the higher concentration of phenolic acids, flavonoids, higher antioxidant capacity and enzyme inhibition properties and lower saturated fatty acid concentration than the Italian sample. The in vivo studies showed that compared to the Italian hazelnuts, the addition of Turkish hazelnuts to high fat diet was associated with a more significant decrease in body weight, food consumption, atherogenic index, lipid peroxidation levels and biochemical/morphological markers of liver injury. Also, from our results, the two hazelnut varieties were protective against β-amyloid-induced neurochemical changes and high-fat diet induced alteration of metabolic indices.
... In another study using hamsters no significant in weight was observed throughout the experimental period (Caimari et al., 2015). However in a recent study Abeer and Amr (2013) examined the effect of dietary supplementation with hazelnut on food intake and body weight in a rat model of diabetes and reported that hazelnut-enriched diet caused a dose-related decrease in food intake and a significant decrease in body weight gain compared to rodents fed A. Mollica et al. Journal of Functional Foods 47 (2018) 562-574 normal diet. ...
... In this study the consumption of Italian hazelnut enriched diet resulted in a dose-related (0.5, 1%) increase in blood glucose levels compared to mice fed normal diet or HFD; while Turkish hazelnut-enriched diet had a normoglycaemic effect. These results corroborates a few studies in humans reporting that supplementation with hazelnut diet did not significantly alter blood glucose levels (Lima et al., 2017;Perna et al., 2016), although Abeer and Amr (2013) reported a hypoglycaemic effect of hazelnut-enriched diet in rats. Hazel-enriched diet mitigated also against HFD-induced alteration in liver weight, biochemistry and morphology as well as omental fat weight and morphometry (Turkish hazelnut), this corroborates the result of the study by Abeer and Amr (2013) that also reported similar effects albeit in diabetic rats. ...
... These results corroborates a few studies in humans reporting that supplementation with hazelnut diet did not significantly alter blood glucose levels (Lima et al., 2017;Perna et al., 2016), although Abeer and Amr (2013) reported a hypoglycaemic effect of hazelnut-enriched diet in rats. Hazel-enriched diet mitigated also against HFD-induced alteration in liver weight, biochemistry and morphology as well as omental fat weight and morphometry (Turkish hazelnut), this corroborates the result of the study by Abeer and Amr (2013) that also reported similar effects albeit in diabetic rats. ...
... However, the observed significant increase in BUN in the DC and treated diabetic groups may be unrelated to renal function. However, contrary to our results, some researchers have observed that there was a significant increase in serum concentrations of BUN, UACA, and CREA in the DC group when compared to the NC group [24]. ...
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Treatment of diabetic patients with antioxidant, such as extra virgin olive oil (EVOO), may be beneficial in numerous debilitating complexities. This study was aimed at assessing the protective role of virgin olive oil in reducing hyperglycemia in streptozotocin- (STZ-) induced diabetic rats. Thirty-six healthy male Sprague-Dawley rats were divided into six groups (6 rats per group) including nondiabetic control (NC), diabetic control (DC), and animals treated with metformin, olive oil, and a combination of olive oil and metformin, respectively. The protective effect of olive oil was evaluated by determining the biochemical parameters (lipid profile, liver, and kidney) and by studying the histopathological alterations in pancreas, liver, and kidney tissues. The results showed a significant increase in alanine aminotransferase (ALT) and alkaline phosphatase (ALP) levels in diabetic rats. ALP levels remained significantly elevated in the diabetic rats that were treated with metformin and/or olive oil, and the highest level was noted in the group treated with olive oil (568.33 U/L). Contrarily, pretreatment with olive oil significantly decreased ALT (67.64 U/L) and ALP (226.17 U/L) levels. Histopathological data revealed that all the disorganized islets of Langerhans along with the clusters of inflammatory cells were absent in the group pretreated with the combination of virgin olive oil and metformin, which shows that prophylactic administration of this combination reduces the diabetic complications in a much better way. Therefore, pretreatment with olive oil with or without metformin is an encouraging approach for diabetes therapy with immense potential.
... [5][6][7][8]45 In ITM, eating hazelnut has been considered in the treatment of AD. [6][7][8] As shown by several studies conducted on hazelnut, it was frequently observed that the consumption of hazelnut is an effective diet that lowers blood glucose level and improves liver and kidney dysfunctions and also protects against the development of hyperlipidemia in diabetic rats. 46,47 Antioxidant activity, 48 antimicrobial activity, 49 antiobesity effect 50 and acetylcholinesterase inhibition 51 of hazelnut have also been reported. ...
Article
Objectives: Corylus avellana L. (hazelnut) is known to be a delicious and nutritious food. This study was carried out to evaluate the use of hazelnut as a therapy for memory impairment because in Iranian traditional medicine, it is recommended for those suffering from a particular type of dementia, with symptoms of Alzheimer's disease. Methods: In this study, rats were fed with hazelnut kernel [(without skin) 800 mg/kg/day] during 1 week before stereotaxic surgery to 24 hours before behavioral testing (in general, for 16 consecutive days) and the effect of hazelnut eating on memory, anxiety, neuroinflammation and apoptosis was assessed in the amyloid beta-injected rat. Results: The results of this study showed that feeding with hazelnut improved memory, (which was examined by using Y-maze test and shuttle box apparatus), and reduced anxiety-related behavior, that was evaluated using elevated plus maze. Also, western blotting analysis of cyclooxygenase-2, interleukin-1β, tumor necrosis factor-α, B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, and caspase-3 showed that hazelnut has an ameliorating effect on the neuroinflammation and apoptosis caused by Aβ. Discussion: These findings suggest that hazelnut, as a dietary supplement, improves healthy aging and could be a beneficial diet for the treatment of AD.
... According to the data reported in ethnobotanical studies, C. avellana has been used for the treatment of varicose veins, hemorrhoids, diabetes mellitus and gynecological disorders (Sezik et al., 1997;Ramalhosai et al., 2011;Abeer and Amr, 2013). The aim of the present study was to evaluate the activity potential of C. avellana oil in the treatment of PCOS and analyze the phytochemical constituents by using chromatographic methods in order to find out the compounds responsible from the efficacy. ...
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The aim of the present study was to assess the activity of the hazelnut oil in the treatment of polycystic ovary syndrome in rats. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, serum lipid parameters, leptin and glucose levels were evaluated. Moreover, antioxidant activity was tested using superoxide dismutase, malondialdehyde, catalase, glutathione peroxidase levels. The phytosterol content of the oil was determined by HPLC. The plasma high density lipoprotein-cholesterol level was found to be significantly high and leptin and glucose concentrations were found to be significantly low in the treatment group. According to the phytochemical analysis, the main components of the oil were detected as α-tocopherol, γ-tocopherol, squalene, β-sitosterol, campesterol and stigmasterol. Corylus avellana oil was found to be effective in the treatment of polycystic ovary syndrome via regulating gonadotropins, steroids and serum lipid parameters and possesses antioxidant activity.
... The early administration of cinnamon extract can prevent insulin resistance and improve insulin signaling [84]. Lower blood glucose, total lipids, triglycerides, total cholesterol , AST, ALT, blood urea nitrogen, uric acid and creatinine ; lower in levels of insulin, thyroid stimulating, folliclestimulating and luteinizing hormones 2013[141] 31[145] Cao et al. found water-soluble extract and purified polyphenols from cinnamon shows insulin-like activity [85], which related to the enhanced expression of TTP, IR, and GLUT4 and the anti-inflammatory and/or anti-angiogenesis activity of cinnamon polyphenols. Moreover, it suggested the polyphenol extract from cinnamon exhibits insulinindependent/like activity on the regulation of gene expression including a decreased expression of specific insulinsignaling pathway genes [86]. ...
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Significant evidences have shown that the polyphenol-rich diets have the ability to protect against diabetes. Since the last several reviews focused on the nutrition and health effects including type 2 diabetes of polyphenols in 2007-2008, a number of related original publications have appeared in this area. This review summarizes important advances related to influence of dietary polyphenols and polyphenol-rich diets on preventing and managing type 2 diabetes, as well as diabetes-mediated changes in bioactivities of dietary polyphenols. It looks like that anthocyanins or anthocyanin-rich foods intakes are related to the risk of type 2 diabetes, but there is no association for other polyphenol subclasses. It illustrated that procyanidins are more active when administered individually than when mixed with food. The benefits of dietary polyphenols for type 2 diabetes can be summarized as: protection of pancreatic β-cells against glucose toxicity, anti-inflammatory, antioxidant, inhibition of starch digestion, inhibition of α-amylases or α-glucosidases, and inhibition of advanced glycation end products formation. Moreover, type 2 diabetes also significantly influence the benefits of dietary polyphenols, although there are very limited studies have been conducted so far. However, how type 2 diabetes impact the pharmacology of dietary polyphenols are not well understood. An understanding of type 2 diabetes-mediated changes in pharmacokinetics and bioactivity of dietary polyphenols will lead to improve the benefits of these phytochemicals and clinical outcomes for type 2 diabetics.
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Diabetes mellitus is one of the most common non communicable diseases around the world and is responsible for many deaths resulting from some of its serious complications. Senna occidentalis Linn. is extensively being used in folklore medicine to cure and/or manage many disease conditions, although its adequate validation as therapeutic (specifically anti-diabetic and hepatoprotective) effects has not been established. The aim of this study is to determine the effects of Senna occidentalis leaf supplement on blood glucose level, liver enzymes and total protein in alloxan-induced diabetic wistar rats. Diabetes was induced by single intraperitoneal injection of alloxan (150 mg/kg). Thereafter the rats were fed with Senna occidentalis leaf supplement at doses of 12.5%, 25% and 50% .Also Glibenclamide was used as a standard drug (2 mg/kg ) as positive control and diabetic control received distilled water as negative control. Blood glucose levels were measured at day 0, 4, 8, 12 and 16. The liver enzymes and total protein were also determined using the serum and histopathological studies of the pancreas and liver were conducted. Quantitative phytochemical screening revealed that the supplement has high amount of phytoconstitutuents like total phenols, flavonoids, tannins, saponins and alkaloids, which have a percentage composition of 20%, 10.80%, 15%, 0.55% and 7.20%, respectively. Blood glucose levels of all animals treated with the supplement were reduced significantly (p<0.05) by about 82.13%, 88.36 and 81.78% respectively when compared with that of the untreated diabetic control group. There was also an increase in the total protein (p< 0.05) to 90.98 ± 6.02, 73.72 ± 3.02 and 92.23 ± 4.01, respectively in comparison to that of the untreated diabetic group having 69.04 ± 3.59; and hepatotoxicity due to the observed increase in the activities of all the liver enzymes as well as hepatocellular necrosis, sinusoidal congestion and hemorrhage as revealed in the histopathological studies of the liver. This study shows that S. occidentalis leaf supplement has potent hypoglycemic effect due to its high content of active principles that possess strong and potent insulinomimetic and β-cell regenerating potential as depicted by the histopathological studies of the pancreatic tissue, even though, some cytotoxic agents like the cytotoxic saponins may be present in the supplement which is capable of causing damage to both pancreas and liver . These findings prove its use in traditional medicine for the treatment of diabetes but with caution due to its probable potential to induce hepatotoxicity. Keywords : Antidiabetic, Hepatoprotective, Hepatotoxicity, Phytoconstitutuents, Insulinomimetic, Senna occidentalis
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Introduction: Idiopathic male infertility is a global problem with almost no definite medicinal treatment. Most patients have to go through intrauterine insemination or assisted reproductive technology for achieving fertility. Unfortunately, success rates are low in cases with very low sperm count. Therefore it seems that improvement in sperm quality can have beneficial effects on assisted reproductive technology outcome. Case report: A 39-year-old man with history of infertility for 6 years was referred to the traditional medicine clinic with a recurrent unsuccessful intracytoplasmic sperm injection trial. His sperm analysis showed severe oligoasthenoteratozoospermia. After taking a traditional remedy he had a remarkable improvement in his sperm parameters, which led to the formation of 8 embryos in the following intracytoplasmic sperm injection cycle. Conclusion: Traditional medicine presents various food and remedy options for treating male infertility. It seems that combination therapy can be beneficial in obtaining better results in treatment of male idiopathic infertility.
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