Pharmaco-Therapeutic Profiles of Chandraprabhavati- An Ayurvedic Herbo-Mineral Formulation

Abstract

The knowledge about indigenous therapeutics was deposited in the ayurvedic classics like Charaka Samhita, Sushruta Samhita, Ashtanga hrudaya etc. These works of ancient period mainly incorporated herbal formulation and a few herbo-mineral compounds. During medieval period the works like Gadanigraha, Chakradatta and Saranagadhara Samhita included certain herbo-mineral and mineral preparations (containing mercury and certain heavy metal like Gold, Lead etc.). Among the herbo-mineral preparations ChandraprabhaVati was formulated with broad spectrum activity. It is a safe formulation containing Loha (Iron)and shilajita (Bitumen) without any heavy metals.Certain researches had been carried out related to its hypoglycaemic, hypotensive and bacteriostatic activities.Pharmaco-therapeutic profile clearly indicate that Chandraprabha Vati is useful in 31 disease conditions like Prameha (Urinary disease including diabetes), Ashmari (Urolithiasis), Katishoola (lumbago), Shoola (Pain in abdomen), Kamala (Jaundice), Pleeharoga (Splenomegaly), Arsha (Piles), Bhagandhara (Fistula in ano), shukradosha (Defective spermatogenesis), Artavaruja (Dysmenorrhea)etc. The details are furnished in this paper.

Full text

*Corresponding Author: Dr.Sushama B Bhuvad, Email:bsushama87@gmail.com
ISSN 0976 – 3333
REVIEW ARTICLE
Available Online at www.ijpba.info
International Journal of Pharmaceutical & Biological Archives 2012; 3(6):1368-1375
Pharmaco-Therapeutic Profiles of Chandraprabhavati- An Ayurvedic Herbo-Mineral
Formulation
Sushama.B*, K.Nishteswar
Department of Dravyaguna, Institute for Post Graduate Teaching and Research in Ayurveda, Gujarat Ayurveda
University, Jamnagar- 361008
Received 11 Sep 2012; Revised 01 Dec 2012; Accepted 09 Dec 2012
ABSTRACT
The knowledge about indigenous therapeutics was deposited in the ayurvedic classics like Charaka
Samhita, Sushruta Samhita, Ashtanga hrudaya etc. These works of ancient period mainly incorporated
herbal formulation and a few herbo-mineral compounds. During medieval period the works like
Gadanigraha, Chakradatta and Saranagadhara Samhita included certain herbo-mineral and mineral
preparations (containing mercury and certain heavy metal like Gold, Lead etc.). Among the herbo-
mineral preparations ChandraprabhaVati was formulated with broad spectrum activity. It is a safe
formulation containing Loha (Iron)and shilajita (Bitumen) without any heavy metals.Certain researches
had been carried out related to its hypoglycaemic, hypotensive and bacteriostatic activities.Pharmaco-
therapeutic profile clearly indicate that Chandraprabha Vati is useful in 31 disease conditions like
Prameha (Urinary disease including diabetes), Ashmari (Urolithiasis), Katishoola (lumbago), Shoola
(Pain in abdomen), Kamala (Jaundice), Pleeharoga (Splenomegaly), Arsha (Piles), Bhagandhara (Fistula
in ano), shukradosha (Defective spermatogenesis), Artavaruja (Dysmenorrhea)etc. The details are
furnished in this paper.
Key words: Indigenous therapeutics, Charaka Samhita, Sushruta Samhita, Ashtanga hrudaya , herbal
formulation, herbo-mineral compounds.
INTRODUCTION
AcharyaCharaka identified three important organs
i.e. Shira (Head/Brain), Hridaya (Heart) and Vasti
(Urinary bladder and related organs of urine
formation) under the heading of Trimarmas
(Three vital parts of the body) [1]
Table 1: Showing various references quoted in different Ayurvedic text
. Keeping in view
of the importance of these organs Charaka had
allocated a separate chapter which details the
management of different diseases originating or
involving these organs. Ayurvedic claims
enumerated for certain diseases related to Vasti
such as Mutrakruchhra (Dysuria), Mutraghata
(Anuria), Prameha (It includes diabetes mellitus
and D. insipidus), Asthila (Benign prostate
hypertrophy) and Ashmari (Urolithiasis), Sotha
(Edematous condition due to involvement of
Heart, Liver, Kidney), Chhardi (Vomiting
including condition like Uraemia), Hikka
(Hiccup), Adhogata raktapitta (Haematuria)have
also been described with certain formulations
containing Punarnava, Gokshura, Dashamoola
etc. ChandraprabhaVati appears to be one of the
potent herbo-mineral formulation having wider
therapeutic application in such conditions.
S. No
[2]
Reference
Indication
1
R.Ra.su, R.R.S, Ha.Sam
Meha
2
G.Ni
Gudaja Vydhi, Mutravaha strotasa Vydhi, Meha, Shukragata Vydhi, Pandu, kamala,
Shosha, Gulma, Granthi, Arbuda, Shleepada
3
Bh.P, V.S, R.Ka.Dh, R.Ch, Bh.R
Jwara, Atisara, Grahani vikara, Gudagata vikara, Pandu, Kamala, Meha,
Grudhrasi, Mutravaha srotoja Vyadhi, Marmagata Vyadhi, Vrana, Udara
4
Sh.S, Bh.R, Br.Y.T.
Prameha, Mutravaha srotaja vyadhi, Anaha, Shoola, Shwasa, Kasa, Shukradosha,
Pandu, Kamala, Gudagata Vyadhi, Netraroga, Dantaroga, Kushtha
5
R.Ka.Dh
With Mercury
+
Sulphur combination
Shwitra Kushtha
6
R. Ka.Dh
Pama Kushtha
7
R. Ra. Su, R.Ch, R.Ka.Dh,
Y.R, Br.Y.T
Tridoshaja Atisara, Jwara

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8
R. Ra. Su, Ra.Sa.Sam,
Rasendrachintamani
Sarvameha
Various Ayurvedic formulations with the name
of ChandraprabhaVati:
Various formulations quoted in ayurvedic texts
with the name of ChandraprabhaVati are
analysed with a main emphasis on the marketed
formulations currently being prescribed in general
practice. The published data on the studies carried
out with ChandraprabhaVati have also been
reviewed.
In total 8 formulations with the name of
ChandraprabhaVati were recorded in various
compendia of Ayurveda like Harita Samhita,
Gada nigraha, Vangasena, Sharangadhara
samhita, Bhavaprakasha samhita, Yogaratnakara,
Bhaishajya ratnavali, Rasa Rajasundara, Rasa
ratnasamuchhaya, Rasachandashu, Brihat
yogatarangaini, Rasakamadhenu,
Rasasarasamgraha (Table 1).
Ingredient of ChandraprabhaVati:
The analysis of data clearly indicates that, out of 8
formulations four formulations have mercury and
sulphur combination. Though Chandraprabha
Vati mainly indicated in treatment of Prameha,
Mutravaha srotaja vikara but the other
formulations with the same name quoted in
various texts have incorporated the diseases like
Kushtha, Atisara, Jwara, Udararoga, Netraroga,
Dantaroga, Gudagata Vyadhi in the list of
indication.
ChandraprabhaVatifromSharanagadharasamhita
was included in Ayurvedic formulary of India [3]
Most of the pharmacies like Baidyanath, Dabur,
AVN, Kottakkal Arya Vaidyashala, Sri Sri
Pharmacy, Divya pharmacy are preparing the
Chandraprabhavatiaccording to formulation
mentioned by
Sharangadharasamhita.(http://ayurmedinfo.com/)
The drugs having action on major system like
urinary system, reproductive system are
incorporated in this formulation. It is a herbo-
mineral compound preparation. Its ingredients are
listed below
.
[5] (Table 2).
Table 2: Showing list of ingredient of ChandraprabhaVati. [6,7
S. No
]
Ingredient
Commentary
Action
Indication
Doshaghna
Activity
1
Chandraprabha
Karpoora
Cinnamomum
camphora
(Linn.) Nees &
Eberm.
Vrushya,
ChakshushyaLe
khana,
Daha, Trushna,
Asyavairasya, Meda
daurgandhya nashaka
Kapha-pitta
Shathi
Hedychium spicatum
Ham. ex Smith.
Grahi
Shotha, Kasa, Vrana,
Shwasa, Shoola,
Sidhma
Kapha-Vata
Hypotensive, hypoglycaemic,
anti-inflammatory,
vasodilatory, anti-bacterial,
anti-
fungal, spasmolytic,
analgesic, anti-microbial
Shatavari
Asparagus racemosus
willd.
Rasayana,
Netrya,
Stanyakari,
Balya,
Shukrakari,
Agnipushtida
Gulma, Atisara,
Shotha
Kapha-pitta
Anti-cancer, anti-fungal,
anti-
bacterial, diuretic,
hypoglycaemic, hypotensive,
anti-oxitoxic.
2
Vacha
Acorus calamus Linn.
-
Vanhikara,
Vantikara,
Shakrut-Mutra
vishodhini
Vibandha, Adhmana,
Shoola, Apsmara,
Bhutonmada, Krimi
Kapha, Vata
Sedative, analgesic,
hypotensive, spasmolytic,
anti-microbial, anti-bacterial
3
Musta
Cyperus rotundus Linn.
-
Grahi,
Deepana,
Pachana
Trushna, Jwara,
Aruchi, Krimi
Kapha, Pitta
Anti-inflammatory, Anti-
pyretic, diuretic, smooth
muscle relaxant, anti-
microbial, estrogenic.
4
Bhunimba
Swertia chirayita
(Roxb. ex Flem.) Karst.
Kairata
Sara
Sannipataka Jwara,
Shwasa, Kasa, Shotha,
Trushna,
Kushtha,Vrana, krimi
Kapha pitta
Anti-spasmodic, anti-
inflammatory,
hypoglycaemic, hepato-
protective, anti-cancer,
cardio stimulant, anti-
diabetic.
5 Amruta
Tinospora cordifolia
(Willd.) Miers ex Hook.
f. &Thoms.
Guduchi
Rasayana,
Sangrahana,
Balya
Trushna, Daha, Meha,
Kasa, Pandu, Kamala,
Kushtha, Vatarakta,
Jwara, Krimi,
Prameha, Shwasa,
Arsha, Hrudroga
Tridoshaghna
Hypoglycaemic, anti-
bacterial,
anti-inflammatory, anti-
pyretic, analgesic,
hepato-protective, immune-
modulatory,
anti-stress,
anti-tumour,
anti-
oxidant, hypotensive,
diuretic.
6
Daruka
Cedrus deodara (Roxb.)
Devadaru
-
Vibandha, Adhmana,
Shotha, Tandra,
Kapha vata
Spasmolytic, anti-
inflammatory, anti-bacterial,
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Loud.
Hikka, Jwara,
Prameha, Peenasa,
Kasa, Kandu
anti-fertility, anti-fungal,
anti-diabetic, immune-
modulatory, analgesic.
7
Haridra
Curcuma longa Linn.
-
Varnya
Twak-dosha, Meha,
Shotha, Pandu, Vrana
Kapha, pitta
Anti-bacterial, insecticidal,
anti-inflammatory,
anti- fertility,
anti-protozoal,
anti-fungal,
hypocholesteremic anti-
hepatotoxic.
8
Ativisha
Aconitum heterophyllum
Wall. ex Royle.
-
Pachana,
Deepana
Atisara, Amavisha,
Kasa, Vami, Krimi
Tridosha
Hypotensive, antifertility,
psycho-stimulant,
antidepressant, CNS-
inhibitor, anti-diabetic,
antipyretic, anti-bacterial,
analgesic.
9
Darvi
Berberis aristata DC.
-
Like Haridra
Netra, Karna,
Asyaroga
Kapha pitta
Anti-tumour, hypoglycaemic,
anti-cancer, anti-bacterial,
anti-inflammatory,
hypotensive.
10
Pippali
Moola
Piper longum Linn.
-
Pachana, Bhedi
Anaha, Pleeharoga,
Gulma, Krimi,
Shwasa, Kshaya
Kapha, Vata,
Pittakara
Anti-bacterial, anti-
inflammatory, insecticidal,
hypoglycaemic, anti-
ulcerogenic, immune-
stimulatory, anti-spasmodic.
11
Chitraka
Plumbago zeylanica
Linn.
-
Pachana,
Vanhikrut,
Grahi
Grahani, Kushtha,
Shotha, Arsha, Krimi,
Kasa
Vata-Kapha,
Pittakara
Anti-pyretic, appetiser,
uterotonic, anti-bacterial,
anti-fungal, anti-fertility,
anti-cancer, anti-tumour,
hepatoprotective.
12
Dhanyaka
Coriandrum sativum
Linn.
-
Avrushya,
Mutrala,
Deepana,
Pachana,
Jwaraghna,
Rochana, Grahi
Trushna, Daha, Vami,
Shwasa, Kasa,
Karshya, Vami
Tridosha
Spasmolytic,
Anti-microbial
13
Haritaki
Terminalia chebula
Retz.
-
Deepana,
Medhya,
Rasayana,
Chakshushya,
Aayushya,
Brumhaniya,
Anulomini
Shwasa, Kasa,
Prameha, Arsha,
Kushtha, Shotha,
Udara, Krimi,
Grahaniroga,
Vibandha,
Vishamajwara,
Gulma, Adhmana,
Trushna, Chhardi,
Hikka, Kandu,
Kamala, Anaha,
Pleeha-
yakrut roga,
Ashmari,
Mutrakruchha,
Mutraghata
Tridosha
Anti-microbial, anti-fungal,
anti-bacterial,
anti-
stress, hypotensive,
hypolipidaemic, anti-
spasmodic.
14
Bibhitaki
Terminalia bellirica
Roxb.
-
Bhedana,
Netrahita,
Keshya,
Madakrut
Kasa, Krimi ,
Vaisvarya, Trushna,
Chhardi
Tridosha
BP depressant, anti-fungal,
anti-asthmatic,
bronchodilator, anti-bacterial,
anti-stress.
15 Aamalaki
Emblica officinalis
Gaertn.
-
Vrushya,
Rasayana
Prameha, Raktapitta
Tridosha
Spasmolytic,
Hypolipidaemic, anti-
microbial, anti-oxidant,
immune-modulatory, anti-
fungal, anti-tumour,
hypoglycaemic, anti-
inflammatory
Triphala
-
Sara,
Chakshushya,
Deepana,
Ruchya
Meha, Kushtha,
Vishamajwara
Tridosha
16
Chavya
Piper chaba Hunter
non-Blume.
-
Like
pippalimoola
Gudajaroga
17
Vidanga
Embelia ribes Burm. f.
-
Vanhikara
Shoola, Adhmana,
Udara, Krimi,
Vibandha
Vata kapha
Estrogenic, hypoglycaemic,
anti-biotic, anthelminthic,
anti-fertility, anti-
inflammatory, hypotensive,
diuretic, hepato-protective,
immune-stimulant
18 Gajapippali
Scindapsis officinalis -
Vanhivardhini
Atisara, Shwasa,
Kantharoga, Krimi
Hypoglycaemic, anti-
protozoal
19 Shunthi
Zingiber officinale
Rosc.
-
Pachani,
Vrushya,Svarya
,Grahi
Amavata, Vibandha,
Vami, Shwasa, Shoola,
Kasa, Hrudroga,
Shleepada, Shotha,
Kapha, Vata
Anti-inflammatory,
hypolipidaemic, antiemetic,
anti-ulcer, anti-pyretic, anti-
oxidant, anti-bacterial,
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Arsha, Anaha, Udara
analgesic, hypoglycaemic,
hepatoprotective
20
Maricha
Piper nigrum Linn.
-
Deepana
Shwasa, Shoola, Krimi
Vata, Kapha,
Pittakara
Anti-oxidant, sedative,
analgesic, CNS depressant,
muscle relaxant, anti-
inflammatory,
hepatoprotective, anti-fungal,
anti-ulcer, lipolytic
21
Pippali
Piper longum Linn.
-
Deepana,
Vrushya,
Rasayani,
Rechani,
Medhya
Shwasa, Kasa, Udara,
Kushtha, Prameha,
Gulma, Arsha,
Pleeharoga, Shoola,
Jwara
Kapha, Vata
Anti-bacterial, anti-
inflammatory, insecticidal,
hypoglycaemic, anti-
ulcerogenic, immune-
stimulatory, anti-spasmodic.
22
Trivrut
Operculina turpethum
(Linn.) Silva Manso.
-
Rechana
Jwara, Shotha, Udara
Pitta, Kapha,
Vatavardhaka
Anti-bacterial, anti-
inflammatory, anthelmintic,
cardiac depressant,
spasmodic to smooth muscle,
and skeletal muscle.
23
Danti
Baliospermum
montanum
(Willd.) Muell.-Arg.
Danti moolatwak
Or Dantibeeja
Sara, Deepana
Gudankura, Ashmari,
Shoola, Kandu,
Kushtha, Daha,
Shotha, Udara, Krimi
Kapha-Pitta
Anti-asthmatic, anticancer,
hypotensive, purgative
24
Patraka
Cinnamomum tamala.
-
Arsha, Hrullasa,
Aruchi, Peenasa
Vata, Kapha
Anti-bacterial,
hypoglycaemic, anti-oxidant,
anti-fungal,
anti-microbial,
hypolipidaemic,
25
Twak
Cinnamomum
zeylanicum.
-
Shukrala, Balya
Mukhashosha,
Trushna
Vata, Kapha,
Pittakara
Anti-allergic, lipolytic,
anti-fungal,
anti-microbial, anti-oxidant,
anti-bacterial
26
Ela
Sthula
Amomumsubul
atum Roxb.
-
Analakara
Kandu, Shwasa,
Trushna, Hrullasa,
Visha, Bastyaroga,
Asyaroga, shiroroga,
Vami, Kasa
Tridosha
Hypoglycaemic
Sukshma
Elettaria
cardamomum
Maton.
Shwasa, Kasa, Arsha,
Mutrakruchha
27 Vanshalochana
Bambusa bambos (L.)
Voss.
-
Brumhani,
Vrushya, Balya
Trushna, Kasa,
Shwasa, Jwara,
Kshaya, Kamala,
Mutrakruchha, Vrana,
Pandu, Kushtha
Vata,Pitta
28
Guggulu
Commiphora mukul
(Hook. ex Stocks) Engl.
-
Sara,
Bhagnasandhan
akara, Vrushya,
Svarya,
Rasayana,
Deepana, Balya
Medoroga, Meha,
Kushtha, Pidaka,
Granthi, Shotha,
Arsha, Gandamala,
Krimi, Vrana, Apachi
Tridosha
Hypolipidaemic, anti-
bacterial, anti-inflammatory,
hypocholesteremic, anti-
fertility, atherosclerotic, anti-
arthritic, Ca2+antagonist
activity
29
Makshika
Iron pyrite
Swarna
Makshika
Vrushya,
Rasayana,
Svarya,
Chakshushya
Kshaya, Arsha, Meha,
Pandu, Shotha,
Kushtha, Jirnajwara,
Apsmara, Arochaka
Tridosha
30
Yavakshara
Potassium Salt
-
Deepana,
Pachana,
Hrudya, Sara,
Mutrala, Sveda-
pravartaka
Gulma, Pleeharoga,
Shoola, Anaha, udara,
Adhmana,
Mutrakruchha,
Kantharoga, Meha,
Shotha
Kapha, Vata
31
Svarjiaka kshara
Potassium Salt
-
Pachana, Agni-
diptikara
Kasa, Shwasa, Gulma,
Adhmana, Vrana,
Udara, Krimi
Vata
32
Saindhava
Sodium Chloride
-
Hrudya,
Vrushya,
Netrya,
Ruchikara,
Pachana,
Deepana,
Vranadosha,
Vibandha
Tridosha
33 Sauvarachala -
Hrudya,
Pachana,
Deepana,
Rochana,
Bhedana,
Gulma,Vibandha,
Anaha, Shoola, Krimi,
Arochaka
Vatanuloman
a
34
Bid lavana
-
Deepana,
Hrudya
Ajirna, Anaha, Shoola,
Vibandha
Kapha
vatanulomana
35
Loha
Iron
-
Lekhana,
Netrya, Balya,
Vrushya,
Varnya, Medhya
Jathararoga
Kapha, Pitta
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36
Sharkara
Sugar
-
Ruchya,
Shukrala
Murchha, Chhardi,
Jwara
Vata , Pitta
37
Shilajatu
Asphaltum punjabinum
-
Mutrala,
Rasayana,
Chhedi,
Ashmari, Sharkara,
Mutrakruchha,
Kshaya, Shwasa,
Apsmara, Arsha,
Unmada, Shotha,
Kushtha, Udara,
Krimi
Kapha
Indications of ChandraprabhaVati:
Various diseases related to the MutravahaStrotasa
(Urinary System), ShukravahaStrotasa
(Reproductive system), Medoroga (Obesity) etc.
are included in the indications. The indications
given for Chandraprabha Vati (Sarangadhara
samhita) are as follows (Table 3):
Table 3: Showing different indications of ChandraprabhaVati mentioned in SharangadharaSamhita
S. No
Disease condition
Dosha
Dushya
Strotasa
1
Prameha -20 type
Tridosha
Meda, Rakta, Shukra, Ambu,
Vasa, Rasavaha, Oja, Lasika,
Majja, Mamsa
Udakavaha, Medovaha,
Mutravaha
2
Mutrakruchha
Vata
Mutravaha
3
Mutraghata
Vata
Mutravaha
4
Ashmari
Vata, Kapha
Mutravaha
5
Vibandha
Vata
Purishavaha
6
Anaha
Vata
Purishavaha
7
Shoola
Vata
Purishavaha
8
Upadansha
Tridosha
Shukravaha
9
Shukadosa
Tridosha
Shukravaha
10
Granthi
Tridosha
Rakta, Mamsa, Meda, Sira
Raktavaha, Mamsavaha
11
Arbuda
Tridosha
Mamsa, Rakta
Raktavaha, Mamsavaha
12
Aantravrudhhi
Vata
Mamsavaha
13
Katishoola
Vata
Asthivaha
14
Shwasa
Vata, Kapha
Pranavaha, Rasavaha
15
Kasa
Vata
Pranavaha, Rasavaha
16
Vicharchika
Vata, Kapha
Rasavaha, Raktavaha
17
Andavrudhhi
Vata
Shukravaha
18
Pandu
Pitta
Rakta, Mamsa
Rasavahavaha
19
Kamala
Pitta
Rakta, Mamsa
Raktavahavaha
20
Halimaka
Vata, Pitta
Raktavahavaha
21
Kushtha
Tridosha
Twak, Rakta, Mamsa, Ambu
Rasavahavaha, Raktavaha,
Mamsavahavaha
22
Arsha
Tridosha
Twak, Mamsa, Meda
Mamsavaha
23
Kandu
Kapha
Twak
24
Pleehodara
Pitta, Kapha
Rakta
Raktavahavaha
25
Bhagandara
Vata
Mamsa
Mamsavaha
26
Dantaroga
Tridosha
Asthi
Asthivaha
27
Netraroga
Tridosha
Majja
Majja vaha
28
Artavaruja
Vata
Artavavaha
29
Shukragata Dosha
Vata
Shukravaha
30
Mandagni
Annavaha
31
Aruchi
Kapha
Annavaha, Rasavaha
It appearsthat ChadraprabhaVati mostly acts on
Tridoshas; Rakta, Mamsa, Meda, Shukra Dhatu;
Purisha, Mutra malas; Rasavaha, Raktavaha,
Mamsavaha, Medovaha, Shukravaha,
Purishavaha andMutravaha srotasa.
Research studies:
1. An experimental study was carried out to
observe the effect of ChandraprabhaVati
on alloxan induced diabetes in rabbits and
significant regression of fasting blood
sugar was noted. The improvement in
hyperglycaemia suggests that either the
drug helps in regeneration of the islets of
Langerhans or it stimulates the secretion of
undamaged ones.
2. In a clinical experiment the single dose of
ChandraprabhaVati on blood sugar in
diabetes has been estimated. And the effect
of ChandraprabhaVati on blood sugar
level in usual subjects has been estimated.
In both these experiments the fasting blood
sugar has been recorded. The peak of the
action has been noted in 2 hours and
hypoglycaemic effect had a reducing trend
after 3 hrs.
In another study ChandraprabhaVati has
been administered in the dose of 3gm/day
in 3 divided doses before meals, for the
period of 3 months in 20 cases of maturity
onset DM. The patients were kept on
hospital diet. The assessment of the result
was done at monthly intervals by clinical
evaluation as well as by repeated glucose
tolerance test. The fall in BSL after
treatment was compared with the initial
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1373
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recording and it was analysed statistically.
The difference was classified as good, fair
and poor control following the criteria of
Joslin’s clinics. On this basis, the inference
has been drawn that ChandraprabhaVati is
a dependable oral hypoglycaemic agent
suitable for the use from mild to moderate
cases of maturity onset diabetes.
(S.N.Tripathi et al) [8]
3. An experimental study had been carried
out to evaluate anti-inflammatory activity
of two ayurvedic formulations containing
Guggului.e.ChandraprabhaVati (CPV)
and Mahayogarajaguggulu (MYG) by
using ethanol extract of CPV and MYG in
carrageenan induced rat paw edema. This
study showed that they have dose
dependent significant anti-inflammatory
activity
.
[9]
4. Polycystic Ovarian Syndrome (PCOS) can
be correlated with the condition known as
AartavaKshayadescribed in Ayurvedic
literature. It is common endocrinopathy in
women of reproductive age. Therefore a
study was carried out to evaluate clinical
efficacy of Ayurveda treatment regimen on
Subfertility with poly cystic ovarian
syndrome (PCOS). Total 40 patients were
selected by using purposive sampling
method. According to the theories of
Ayurveda of Shodhana, Shamana and
Tarpana, the treatment was conducted in 3
stages for the duration of 6 months. The
response to the treatment was recorded and
therapeutic effects were evaluated by
symptomatic relief and through Trans
vaginal scan and LH, FSH hormone levels.
The results revealed that, subfertility due
to PCOS can be cured successfully by
using this Ayurvedic treatment regimen
.
[10]
5. ‘Mutraghata’ is a group of obstructive
uropathic disorders, as explained in
SushrutaSamhita, is of 12 types &
‘Vatashtila’ is one among them, which is
closely similar to Benign Prostatic
Hyperplasia (BPH). Usually men around
60 years, suffer from Mild, Moderate &
Severe grade of BPH. In classics
ChandraprabhaVati(BhaishajyaRatnavali)
&Mustadikalpa (Sushruta Samhita) are
indicated in Mutraghata&Mutrakruccha.
So the study was carried out as single
blind method of diagnosed cases of B.P.H,
.
Chandraprabhavati 1-tid &Mustadikalpa
1-tsp bid given for 30 days & follow-up
was carried upto of 60 days.Changes in
subjective criteria (by IPSS Index) and
objective criteria (by USG) were recorded
before and after the treatment and relief
from the symptoms were
noted.(http://www.neifm.org)
DISCUSSION
The drugs of ChandraprabhaVatilike Yavakshara
and Svarjikakshara- alkaline substances decrease
the acidity of urine and gives relief in burning
micturition. The drugs like Pippalimoola [12] and
Vacha[13,14]act as sedative and relieve anxiety
which help in the management of psycho-somatic
diseases like hypertension, diabetes and obesity.
The drugs namely Trikatu, Chavya, Musta,
Elavaluka, Lavanas, Ksharas help to relieve the
state of Mandagni which is identified as a root
cause for all disease conditions.
ChandraprabhaVati successfully prevents
Diabetic neuropathy, Diabetic retinopathy and
mayprevents the renin formation in Kidney which
is a known cause for essential hypertension. The
drugs like Musta[15], Triphala, Shilajita and
Guggulu[16,17]
AcharyaVagbhata suggests Shilajita as the drug of
choice for the management of Vastigatavyadhi
(Urinary disease)
help to treat dyslipidaemias and
prevent ischaemic condition in all the organs in
the body including Kidney, heart, liver and brain.
[18]. The diseases related to
Mutra (Urine) like Mutraghata (Anuria),
Mutrakrichhra (Dysuria),Ashmari (Urolisthesis)
are indicated for therapeutic application of
Chandraprabhavati. Prameha includes the disease
conditions like Diabetes mellitus and research
studies proved anti-diabetic activity of
ChandraprabhaVati. The drug namely Guggulu is
included in higher quantity which is a proven anti-
inflammatory drug [19]. Inflammatory conditions
in entire genito-urinary tract are amenable with
administration of ChandraprabhaVati. The
conditions like cystitis which presents as dysuria;
the disease like BPH, Epididymitis, Salpingo-
oopheritis are addressed with ChandraprabhaVati.
The formulation acts as anti-spasmodic and
analgesic agent to manage Kashthartava
(Dysmenorrhoea) and Katishoola (Lumbago). It
relieves the infection and acts as spermatopoietic
agent. In a nut shell this is employed in male as
well as female infertility. The drugs like Triphala
[20], Guduchi [21]
IJPBA, Nov - Dec, 2012, Vol. 3, Issue, 6
which are proven anti-oxidants
and anti- tumour agents increase the immunity and
act as immune-modulatory agents in the

Sushama B et al / Pharmaco-Therapeutic Profiles of Chandraprabhavati- An Ayurvedic Herbo-Mineral Formulation
1374
© 2010, IJPBA. All Rights Reserved.
conditions of autoimmune and immune-deficient
state. It protects the liver and act as hematopoietic
agent. Though it contains salts and sugar, the
formulation can be suggested for hypertension and
diabetes as each tablet of 250mg or 500mg
contains least quantity (in milligram) of salt and
sugar.
CONCLUSION
ChandraprabhaVaticontains 37 ingredients of
plant and mineral origin, used in the treatment of
diabetes, diseases of urinary tract, and many other
disease conditions having involvement of all the
three Doshasi.e. Vata, Pitta, Kapha..It has broad
spectrum activity for the management of life style
disorders. It is widely used in Ayurvedic practice,
across the country.
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