Anti-hyperglycemic Effects of Dillenia philippinensis Rolfe. (Dilleniaceae) Crude Leaf Extracts on Hyperglycemic Mice
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ABSTRACT
Several scientific endeavors have been conducted in order to address the increasing problem concerning hyperglycemia leading to diabetes mellitus. Hyperglycemia, being the hallmark characteristic of diabetes mellitus, has been widely studied as part of research endeavors in treating the said disease. In this study, D. philippinensis crude leaf extracts were used to explore its anti-hyperglycemic effects on hyperglycemic mice. Hyperglycemia was induced through the use of oral glucose loading method. Phytochemical analysis of the crude leaf extracts revealed the presence of anti-oxidative substances such as tannins and flavonoids Results of the animal testing procedures showed that the normal control, positive control and the test groups 1, 2, and 3, with 50, 100 and 150 mg/kg dosages, respectively, exhibit significant differences from each other. Moreover, it was found that the dosages affect the hypoglycemic effects of the extract such that highest concentrations produced faster hypoglycemic effects and that these effects significantly wear off after a certain period of time. Nevertheless, it was concluded that D. philippinensis crude leaf extract exhibited significant hypoglycemic effects on hyperglycemic mice.
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Three plants with claims of antidiabetic potential: Dillenia philippinensis (katmon bark), Codiaeum variegatum (San Francisco) and Hydrocotyle vulgaris (Gutokola) were tested for their antidiabetic potential on lowering the blood glucose level in alloxan-induced diabetic mice. D. philippinensis (Katmon Bark) effectively lowered the blood glucose levels of diabetic mice. Upon oral administration of the extract D. philippinensis, the blood glucose level had lowered by 15.92% at 30 mins, 5.57% at 120 mins and 12.43% 24 hours post treatment administration with significantly comparable values on the positive control (glibenclamide) with percentage mean values lowered by 4.88% at 30 mins, 15.5% at 120 mins and 5.8% at 24 hours respectively.
This book contains contributions presented at the last of the Alcuin Symposia, held in April 2000, as a Festschrift to honour Prof. Axel Wollmer on the occasion of his retirement from the Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen. The Alcuin Symposia were initially held alternatively in York and Aachen, in recent years in Aachen only, as joint workshops on insulin between the groups of Prof. Guy Dodson in York and the groups of Profs Dietrich Brandenburg and Axel Wollmer in Aachen. The Symposium was named after Alcuin, an Anglo-Latin poet, educator and cleric from York, who was invited to join the court of Charlemagne at Aachen. Alcuin’s first 50 years were spent in Yorkshire, were he was first a pupil, later headmaster of the cathedral school of York, the most renowned of its day. Charlemagne was gathering at Aachen the leading Irish, English and Italian scholars of the age. Alcuin was appointed head of the Palatine school, where Charlemagne himself, his family, his friends, and his friends’s sons were taught. Alcuin introduced the traditions of Anglo-Saxon humanism into Western Europe and was the foremost scholar of the revival of learning known as the Carolingian Renaissance. He also promoted the use of the beautiful Carolingian minuscule script, the ancestor of modern Roman typefaces.
Diabetes is now one of the major causes of morbidity worldwide. In many cases, the onset of diabetes is progressive, developing via a condition of insulin resistance. This book considers the development of this condition, its consequences and clinical and therapeutic aspects. The book reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. Provides an expert review of the phenomenon of insulin resistance Brings together a host of recent research for the first time Written by leading experts in biological and clinical research.