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August von Kotzebue’s Bruder Moritz, der Sonderling and German Transcultural Consciousness around 1800
Abstract
abstract:
August von Kotzebue’s drama Bruder Moritz (1791) demonstrates the impact of non-European cultures on the German discourse and expresses a transcultural consciousness in German culture around 1800. Discussing Moritz’s friendship with the Arab Omar and Moritz’s provocative attitude toward female virtue and the incest taboo, this essay shows how Omar co-constructs Moritz’s identity and empowers him to imagine a different moral and social order. Moreover this essay foregrounds the happy ending of Moritz’s refuge in the remote Pacific Islands and argues that non-European cultures evoke the generic instability of bourgeois tragedy and pave ways for melodramas with happy endings.
Cambridge Core - International Relations and International Organisations - The World Imagined - by Hendrik Spruyt
Background and objective:
Recently, differential DNA Methylation is known to affect the regulatory mechanism of biological pathways. A pathway encompasses a set of interacting genes or gene products that altogether perform a given biological function. Pathways often encode strong methylation signatures that are capable of distinguishing biologically distinct subtypes. Even though Next Generation Sequencing techniques such as MeDIP-seq and MBD-isolated genome sequencing (MiGS) allow for genome-wide identification of clinical and biological subtypes, there is a pressing need for computational methods to compare epigenetic signatures across pathways.
Methods:
A novel alignment method, called DEEPAligner (Deep Encoded Epigenetic Pathway Aligner), is proposed in this paper that finds functionally consistent and topologically sound alignments of epigenetic signatures from pathway networks. A deep embedding framework is used to obtain epigenetic signatures from pathways which are then aligned for functional consistency and local topological similarity.
Results:
Experiments on four benchmark cancer datasets reveal epigenetic signatures that are conserved in cancer-specific and across-cancer subtypes.
Conclusion:
The proposed deep embedding framework obtains highly coherent signatures that are aligned for biological as well as structural orthology. Comparison with state-of-the-art network alignment methods clearly suggest that the proposed method obtains topologically and functionally more consistent alignments.
Availability:
http://bdbl.nitc.ac.in/DEEPAligner.
Background:
Identification of pathways that show significant difference in activity between disease and control samples have been an interesting topic of research for over a decade. Pathways so identified serve as potential indicators of aberrations in phenotype or a disease condition. Recently, epigenetic mechanisms such as DNA methylation are known to play an important role in altering the regulatory mechanism of biological pathways. It is reasonable to think that a set of genes that show significant difference in expression and methylation interact together to form a network of pathways. Existing pathway identification methods fail to capture the complex interplay between interacting pathways.
Results:
This paper proposes a novel framework to identify biological pathways that are dysregulated by epigenetic mechanisms. Experiments on four benchmark cancer datasets and comparison with state-of-the-art pathway identification methods reveal the effectiveness of the proposed approach.
Conclusion:
The proposed framework incorporates both topology and biological relationships of pathways. Comparison with state-of-the-art techniques reveals promising results. Epigenetic signatures identified from pathway interaction networks can help to advance Molecular Pathological Epidemiology (MPE) research efforts by predicting tumor molecular changes.
This paper investigates stability analysis and stabilization for networked control systems. By a refined delay decomposition approach, slightly different Lyapunov-Krasovskii functionals (LKFs) with quadruple-integral terms and augmented vectors containing triple-integral forms of state are constructed. New integral inequalities are proposed to estimate the cross terms from derivatives of the LKFs, which can be proved to offer tighter bounds than what the Jensen one produces theoretically. Moreover, the non-strictly proper rational functions in deriving process are fully handled via reciprocally convex approach. A state feedback controller design approach is also developed. Numerical examples and applications to practical power and oscillator systems demonstrate the superiority of the proposed criteria in conservatism reduction compared to some existing ones.
As a very young man, one of the most celebrated English authors of the eighteenth century translated a tome about Ethiopia. This experience permanently marked Samuel Johnson, leaving traces of the African discourse he encountered in that text in his drama Irene;several of his short stories; and his most famous fiction, Rasselas. This book provides a much needed perspective in comparative literature and postcolonial studies on the power of the discourse of the other to infuse European texts. This book illuminates how the Western literary canon is globally produced by developing the powerful metaphor of spirit possession to posit some texts in the European canon as energumens, texts that are spoken through. The model of discursive possession offers a new way of theorizing transcultural intertextuality, in particular how Europe's others have co-constituted European representations. Through close readings of primary and secondary sources in English, French, Portuguese, and G???z, the book challenges conventional wisdom on Johnson's work, from the inspiration for the name Rasselas and the nature of Johnson's religious beliefs to what makes Rasselas so strange.