ArticlePDF Available

A Retrospective Study in 1,070 Feline Tumor Cases of Japan.

Authors:
Takuo Shida
Takuo Shida
Takuo Shida
  • This person is not on ResearchGate, or hasn't claimed this research yet.
Tohru Yamada
Tohru Yamada
Tohru Yamada
  • This person is not on ResearchGate, or hasn't claimed this research yet.
Takuya Maruo at Azabu University
Takuya Maruo
Takuo Ishida
Takuo Ishida
Takuo Ishida
  • This person is not on ResearchGate, or hasn't claimed this research yet.
Show all 12 authorsHide
Download full-text PDF
Read full-text
Download citation

Abstract and Figures

The purpose of this study was to document the incidence of feline tumors in the Japanese cat population. 1,078 feline tumors obtained from 1,070 cats. All of these were cytologically or histologically diagnosed at Azabu University Veterinary Teaching Hospital in Japan from April 1985 to March 2008. The baseline hospital population during the same period included 6,748 cats. The 1,070 tumor-bearing cats were analyzed for age, sex, breed, type of tumors, site-specific tumor incidence and malignant tumor incidence rate. The average age was significantly higher in the tumor group (9.9± 3.8years) than in the baseline hospital population (5.6± 4.9years). As to gender difference, the incidence of tumors was significantly higher in female cats. The incidence rate of malignant tumors in cats was significantly higher with an odds ratio of 4.55 as compared to 6,302 tumor-bearing dogs at the same university teaching hospital. The odds ratio for malignancy was significantly higher in cats for specific tumors such as lymphomas (8.39), the head and neck(5.18), mammary gland(4.55), female genitalia(3.64), and skin/subcutis(1.64) tumors. On the other hand, as compared to dogs, the incidence of the following tumors was significantly lower in cats; mast cell tumor, urologic tumors, male genital tumors, bone and joint tumors and endocrine tumors. This study provided a substantial amount of information useful for client education as well as diagnosis and treatment of feline tumors.
Figures - uploaded by Takuya Maruo
Author content
All figure content in this area was uploaded by Takuya Maruo
Content may be subject to copyright.
Content uploaded by Takuya Maruo
Author content
All content in this area was uploaded by Takuya Maruo on Jun 19, 2021
Content may be subject to copyright.
1
󰰪󰰹󰯥󰰦󰰱








 




A Retrospective Study in 1,070 Feline Tumor Cases
of Japan.
Takuo Shida1）
, Tohru Yamada2）
, Takuya Maruo1）
, Takuo Ishida3）
, Hiroko Kawamura1）
Haruo Takeda1）
, Hiroki Sugiyama1）
, Takeshi Ishikawa1）
, Tetsuro Ito1）
, Hiroo Madarame1）
Hideki Kayanuma1）
, and Tsunenori Suganuma1）
Abstract
   


          
    









Key word：Cat, Epidemiological research , Retrospective study , Tumors.






2
󰰪󰰹󰯥󰰦󰰱

      
      


   

󰰝

  
󰰕


The population studied


Comparison between tumor-bearing cat population and baseline hospital cat population

   󰰵 
        


󰰵󰰵
󰰵

  
Fig. 1．Age distribution of the baseline hospital population and tumor-bearing cats.
󲆉󲆊󲆈󲆈
󲆉󲆈󲆈󲆈
󲆎󲆈󲆈
󲆌󲆈󲆈
󲆊󲆈󲆈
󲆈
Fig. 1 Age distribution of the baseline hospital population and tumor-bearing cats.
󲆉󲆊󲆈󲆈
󲆉󲆈󲆈󲆈
󲆎󲆈󲆈
󲆌󲆈󲆈
󲆊󲆈󲆈
󲆈
Fig. 1 Age distribution of the baseline hospital population and tumor-bearing cats.
3
󰰪󰰹󰯥󰰦󰰱
   


Analysis of tumor-bearing cats

󰰵







󰰵󰰵
󰰵󰰵󰰵









󰰵
󰰵󰰵
󰰵
Fig. 2．Site distribution* and type of 1,078 feline tumors
Skin an
d
Mast Ce
Mamma
r
Head an
A
liment
a
Urinary
S
Genital
S
Genital
S
Bones a
Lympho
Respira
t
Endcrin
e
d
Subcutan
e
ll Tumor
r
y Gran d
d Neck
a
ry System
S
ystem
S
ystem Mal
e
S
ystem Fe
m
nd Joints
id/hematopi
t
ory Tract
e
Grands
e
ous
e
m
ale
etic
Fig. 2 Site distribution* and type of 1,078 feline tumors
Skin an
Mast Ce
Mamma
r
Head an
A
liment
a
Urinary
S
Genital
S
Genital
S
Bones a
Lympho
Respira
t
Endcrin
e
Subcutan
ll Tumor
r
y Gran d
d Neck
a
ry System
S
ystem
S
ystem Mal
e
S
ystem Fe
m
nd Joints
id/hematopi
t
ory Tract
e
Grands
ous
e
m
ale
etic
Fig. 2 Site distribution* and type of 1,078 feline tumors
4
󰰪󰰹󰯥󰰦󰰱





  󰰵 
󰰵󰰵

      
Table 1. Site distribution* and histologic types of com-
mon benign tumors in the cat.
 
 
  
  
  
  
 
  
  
  
 
  
  
  
 
  
  
 
  
  
 
  
  
  
  
 
 
  
 
  
       

 
 
  
  
  
  
 
  
  
  
  
  
 
  
  
  
  
  
 
  
  
  
  
  
  
  
  
 
  
  
  
 
  
  
  
  
 
  
  
  
 
  
  
 
  
  
  
  
 
  
   
Table 2. Site distribution* and histologic types of com-
mon malignant tumors in the cat.
       

5
󰰪󰰹󰯥󰰦󰰱
      



    



                

      









  󰰵              






󰰵







        


  

  
 



6
󰰪󰰹󰯥󰰦󰰱
References
  󰰆󰰩󰰻󰯳󰯥󰰛󰰪󰰹󰯳󰯥󰰘󰰨󰰮󰯳󰯥󰰈󰰴󰰲󰰵󰯳󰯥󰰒󰰪󰰩󰯳
  󰰆󰰲󰯳󰯥󰰏󰯳󰯥󰰛󰰪󰰹󰯳󰯥󰰗󰰪󰰸󰯳
  󰰛󰰪󰰹󰯳󰯥󰰗󰰪󰰨󰯳
  󰰈󰰴󰰳󰰹󰰮󰰳󰯳󰯥󰰊󰰩󰰺󰰨󰯳󰯥󰰕󰰷󰰦󰰨󰰹󰯳󰯥󰰛󰰪󰰹󰯳
         
󰰏󰯳󰯥󰰓󰰦󰰹󰰱󰯳󰯥󰰈󰰦󰰳󰰨󰰪󰰷󰯥󰰎󰰳󰰸󰰹󰯳
  
      󰰏󰯳󰯥󰰓󰰦󰰹󰰱󰯳󰯥󰰈󰰦󰰳󰰨󰰪󰰷󰯥󰰎󰰳󰰸󰰹󰯳

  󰰏󰯳󰯥󰰆󰰲󰯳󰯥󰰆󰰳󰰮󰰲󰯳󰯥󰰍󰰴󰰸󰰵󰯳󰯥󰰆󰰸󰰸󰰴󰰨󰯳
  
󰰊󰰺󰰷󰯳󰯥󰰏󰯳󰯥󰰈󰰦󰰳󰰨󰰪󰰷
  󰰛󰰪󰰹󰯳󰯥󰰕󰰦󰰹󰰭󰰴󰰱󰯳



󰰏󰯳󰯥󰰓󰰦󰰹󰰱󰯳󰯥󰰈󰰦󰰳󰰨󰰪󰰷󰯥󰰎󰰳󰰸󰰹󰯳

󰰏󰯳󰯥󰰏󰰵󰰳󰯳󰯥󰰛󰰪󰰹󰯳󰯥󰰒󰰪󰰩󰯳󰯥󰰆󰰸󰰸󰰴󰰨󰯳



7
󰰪󰰹󰯥󰰦󰰱







Key word：Cat, Epidemiological research , Retrospective study , Tumors.
猫の腫瘍症例1,070例の回顧的分析


















󰽌
... Feline lymphoma is a common neoplastic condition that affects cats worldwide. Lymphoma can arise from lymphoid and non-lymphoid tissues throughout the body and can affect various anatomical locations [1][2][3][4][5]. The classification of lymphoma in cats is complex, with different subtypes identified based on their biological behavior, cell origin, and anatomical location [2,6,7]. ...
... Previous studies have reported variations in the prevalence of different anatomical forms of lymphoma in feline populations across different countries [2,3,5]. Classification based on anatomical location usually differentiates gastrointestinal or alimentary lymphoma from other extranodal forms (nasopharyngeal, renal, central nervous system, etc.), and also multicentric (peripheral lymph nodes), mediastinal, and mixed forms [2,6,7]. ...
... This leads to regional variability of anatomical presentations with gastrointestinal lymphoma being the most prevalent in countries with a low FeLV prevalence [4,[12][13][14], and multicentric and mediastinal forms being more common in countries with a higher rate of FeLV infections [3,15]. Different forms and types of lymphoma have, however, been reported in countries with a relatively low prevalence of FeLV-infected cats such as Australia, Japan, the USA, and other European countries [2,5,[16][17][18]. In Hong Kong, FeLV infection is considered rare, similar to what has been reported in the UK and USA [19]. ...
Description and Characterization of Different Types of Lymphoma in Cats in Hong Kong
Article
Full-text available
  • May 2024
Simple Summary Lymphoma is one of the most common neoplastic malignancies in cats. The relative prevalence of different types of lymphoma in cats living in Hong Kong has never been reported. This study provides valuable information on the frequency, characteristics, and anatomical forms of feline lymphoma in cats in Hong Kong, contributing to the limited knowledge of feline lymphoma in Asian populations. Abstract This study aimed to characterize and describe the different lymphoma types and anatomical forms in cats in Hong Kong. The clinical and histopathological data of cats diagnosed with lymphoma by cytology and/or histopathology were collected from a large diagnostic laboratory in Hong Kong. In total, 444 cats were diagnosed with lymphoma over four years (2019–2022). Like other countries where there is a low prevalence of FeLV infection, the predominant form of lymphoma was gastrointestinal (abdominal). Nasopharyngeal and peripheral nodal lymphoma were the second and third most common forms of lymphoma. The large cell/high-grade lymphoma type was much more common than the low-grade/small cell lymphoma in the study population. Domestic short hair was the most commonly affected breed in our study (n = 259/444). Among the cats with identified T/B-cell status, B-cell lymphoma (n = 61/81) prevailed as the most common phenotype. This study describes and characterizes the different types of feline lymphoma in cats in Hong Kong, adding valuable information to the body of knowledge.
View
... Female dogs have a higher risk of developing tumors than male dogs, but this link is controversial in cats. Shida et al. (2010) reported that the frequency of tumors was substantially higher in female cats, whereas Dorn et al. (1968) observed higher frequencies in male cats. Moreover, lymphomas were more frequently seen in male cats than female cats in another study (Dorn et al., 1968) but further research found that lymphomas had no significant correlation with sex (Shida et al., 2010). ...
... Shida et al. (2010) reported that the frequency of tumors was substantially higher in female cats, whereas Dorn et al. (1968) observed higher frequencies in male cats. Moreover, lymphomas were more frequently seen in male cats than female cats in another study (Dorn et al., 1968) but further research found that lymphomas had no significant correlation with sex (Shida et al., 2010). In addition, one study found that the median age of tumor incidence for cats was 9.5 years old (Pérez-Enriquez et al., 2020), while another reported a median of 9.14 years old (Rafalko et al., 2022;Pinello et al., 2022b). ...
... Various studies on tumor frequency in cats have been published (Gülçubuk et al., 2005;Shida et al., 2010;Manuali et al., 2020). Shida et al. (2010) observed that the skin and subcutis were the most common sites for tumors (n = 318, 29.7%), followed by the mammary glands (n = 182, 17.0%), and the lymphoid/hematopoietic system (n = 176, 16.5%). ...
Evaluation of cat tumors in Samsun between 2004-2022
Article
Full-text available
  • Nov 2023
This study investigated the incidence of various tumors detected in 169 cat tissue and organ samples brought to the Samsun Ondokuz Mayis University, Veterinary Faculty, Department of Pathology between 2004–2022. Of the 169 specimens, five were acquired from necropsy and 164 were biopsy samples. Various tumors were evaluated retrospectively according to localization, sex, breed, and tumor origin. Tumors were common in mixed breeds (n = 96, 56.8%). Age of tumor incidence was examined; cats between 6 and 9 years of age most frequently had tumors (n = 45, 26.6%) in both sexes. In terms of tumor origin, 79 (47.0%) were mesenchymal, 83 (49.4%) were epithelial, and seven (4.2%) were of mixed components, i.e., mesenchymal and epithelial. In total, 147 (87%) tumors were classified as malignant and 22 (13%) tumors were classified as benign. Regardless of sex, the most commonly observed tumors were skin and subcutis tumors (n = 56, 32.1%). In conclusion, tumor incidence in Samsun was determined by retrospectively evaluating tumors in cats according to location, breed, sex, age range, and origin and comparing these with the literature.
View
... For example, the Swiss Feline Tumor Registry [10], which includes data from 51,322 feline patients between 1965 and 2008, serves as a global point of reference. While some studies have been conducted in Asia, such as those in Korean and Japan [17,18], the available data are significantly more limited compared to Western countries, emphasizing the need for more region-specific research in Asian populations. ...
Regional Variations in and Key Predictors of Feline Tumor Malignancy: A Decade-Long Retrospective Study in Korea
Article
Full-text available
  • Oct 2024
Feline cancer is increasingly recognized as a major cause of mortality, yet data on tumor prevalence and behavior in cats, particularly in non-Western regions, remain limited. This study analyzed a decade of feline tumor data in Korea from 2012 to 2022, focusing on age, breed, and anatomical location as predictors of malignancy. Data were collected from 683 cats, with regression analysis applied to determine significant associations. Older cats exhibited a markedly higher risk of malignancy, particularly in mast cell and mammary tumors. Tumors in the mammary gland and alimentary tract had malignancy rates exceeding 90%, underscoring the need for early detection in these regions. Interestingly, squamous cell carcinoma was rare in the skin, in stark contrast to Western studies, likely reflecting differences in environmental exposure. While breed was not a statistically significant predictor, certain breeds, including Persians and Russian Blues, showed a higher frequency of malignancy. These findings highlight the importance of regional tumor research in cats and the need for larger, multicenter datasets that incorporate environmental, genetic, and lifestyle factors. Understanding these influences will help refine veterinary care and improve cancer treatment outcomes in feline populations.
View
... Age average of affected patients was high, as observed by Al Attar et al., (2016), Chun (2005), Harasen and Little (2015), Helm and Morris (2012). Shida et al., (2010) reported mean age of 9,9  3,8 years for general feline neoplasia development, not bone tumors exclusively, in Japan. Likewise, an Italian study reported age from 8 to 11,9 years old for cats presented with neoplasms (Vascellari et al., 2009). ...
Malignant feline primary bone tumors: integrating clinical, radiographic and histopathological findings to improve disease knowledge in cats.
Article
Full-text available
  • Aug 2024
Bone neoplasms are considered rare in feline species. Osteosarcoma (OSA) is responsible for 85% of malignant bone tumors in dogs and 70% in cats, however, demographic information regarding feline OSA is less reliable than in dogs, for being a less ommon disease. Apparently, cats develop osteosarcoma at a higher age average than dogs. Tumor clinical course is slower compared to canine one, especially in appendicular skeleton. Presented study evaluated 14 cases of primary bone tumors in cats, integranting clinical, imaging and histopathological analysis for better understading this disease in feline species. Male cats were the most affected ones (71,4%) and age average for neoplasia development was 9 years old. Bone sclerosis predominated in radiographic images, being justified by histopathological findings. Osteosarcoma (n=10) was the most frequent neoplasia, followed by chondrosarcoma (n=3). The most common osteosarcoma subtype was chondroblastic. The only diagnosed benign tumor was an osteochondroma. Metastasis rate was 46,2% affecting lungs, skin and other bones. The knowledge and relationship observed between clinical, radiographic and pathological findings in feline bone tumors must be taken into consideration to better prognostic determination and disease follow-up in cats.
View
... Chondrosarcoma is a rare spinal tumor in cats. Despite being the second most common type of primary bone tumors in dogs, only 0.3% of all feline malignant tumors were identified as chondrosarcoma in a retrospective study of 938 malignant feline tumors (16,17). In another retrospective study on 85 cats with tumors affecting the spinal cord, lymphoma and osteosarcoma were the most common tumors affecting the spinal cord, followed by glial tumors, meningioma, and fibrosarcoma, whereas chondrosarcoma accounts for only 1% of all feline spinal tumors (11). ...
View
... This difference is postulated to be due to lower quantities of tryptophan metabolites in feline urine, species-specific differences in ectoparasite preventative formulations, and underdiagnosis in geriatric cats with comorbidities. 1,15,16 Similar to dogs, urothelial carcinoma is the most common malignant neoplasm in the feline urinary bladder. 1 History of lower urinary tract disease may be a predisposing factor in the development of urothelial carcinoma in cats. 17 Clinical signs include classic lower urinary tract signs such as hematuria, stranguria, dysuria, and pollakiuria as well as more nonspecific signs of anorexia, lethargy, and vomiting. ...
Pathology in Practice
Article
Full-text available
  • May 2022
  • JAVMA-J AM VET MED A
In collaboration with the American College of Veterinary Pathologists
View
View
Retrospective Evaluation of Canine and Feline Mammary Tumors Diagnosed during the period from 2009 to 2022 in Izmir Province
Article
  • Nov 2024
The aim of this retrospective study was to determine the incidence of canine and feline mammary tumors diagnosed in the Pathology Laboratory of Bornova Veterinary Control Institute in Izmir Province between January 2009 and December 2022, as well as to analyse the relationships between the age and breed characteristics of affected animals and the presence of mammary tumors. For this purpose, the available information regarding each mammary tumor case was collected from archive records. Dogs and cats with mammary tumors were divided into four age groups. All hematoxylin and eosin-stained slides of mammary tumors were histopathologically re-evaluated and classified. The study material consisted of 106 (35.81%) mammary tumor cases, of which 83 (37.55%) belonged to dogs and 23 (30.66%) to cats. The highest incidence of mammary tumors in both species was observed in the age group of 8 to 11 years. A statistically significant relationship was found between the incidences of mammary tumors according to the age groups and breeds in both species (p
View
Primary bone tumors in dogs and cats: 98 casesKöpek ve kedilerde primer kemik tümörleri: 98 vaka
Article
  • Dec 2023
The aim of this study is to contribute to the current literature by determining the distribution of bone tumors in dogs and cats by breed, age, gender and location. Bone tumors are more common in dogs than cats, and the most common primary bone tumor in both species is osteosarcoma. The biopsy and necropsy reports of the Ankara University, Faculty of Veterinary Medicine, Department of Pathology , were retrospectively studied examining for cases of primary bone tumors in dogs and cats. This study's period encompassed from 2001 through 2020 (20 years). A total of 98 bone tumors were detected 70 in dogs and 28 in cats. Of the cases in dogs, 13 (18.57%) were necropsy, while 57 (81.43%) were biopsy. Sex distribution of bone tumors is in female dogs (n:28, 40%) and in male dogs (n:38, 54.29%). Also, females (n:17, 60.7%) and males (n:11, 39.3%) were observed in cats. in dogs, although 57.14% (n=40) were purebreds and 31.43% (n=22) were mongrel breeds, in cats, 75% of them were mongrel (n=21) and 7.1% (n=2) were purebred. While locations of tumors in dogs were appendicular (65.71%, n=46), axial (30%, n=21), locations of tumors in cats were appendicular (50%, n=14), axial (39.29%, n=11) and both appendicular and axial (10.71%, n:3). While 13 benign (18.57%) and 57 malignant (81.43%) tumors were observed in dogs, 4 benign (14.29%) and 24 malignant (85.71%) tumors were observed in cats. The data were analyzed in the SPSS program and no significant relationship was detected between the data (P>0.05). This study would contribute and conduce the comparative oncology for dogs and cats.
View
Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Article
Full-text available
  • Aug 2023
  • GENOME BIOL
Background In humans, muscle-invasive bladder cancer (MIBC) is highly aggressive and associated with a poor prognosis. With a high mutation load and large number of altered genes, strategies to delineate key driver events are necessary. Dogs and cats develop urothelial carcinoma (UC) with histological and clinical similarities to human MIBC. Cattle that graze on bracken fern also develop UC, associated with exposure to the carcinogen ptaquiloside. These species may represent relevant animal models of spontaneous and carcinogen-induced UC that can provide insight into human MIBC. Results Whole-exome sequencing of domestic canine (n = 87) and feline (n = 23) UC, and comparative analysis with human MIBC reveals a lower mutation rate in animal cases and the absence of APOBEC mutational signatures. A convergence of driver genes (ARID1A, KDM6A, TP53, FAT1, and NRAS) is discovered, along with common focally amplified and deleted genes involved in regulation of the cell cycle and chromatin remodelling. We identify mismatch repair deficiency in a subset of canine and feline UCs with biallelic inactivation of MSH2. Bovine UC (n = 8) is distinctly different; we identify novel mutational signatures which are recapitulated in vitro in human urinary bladder UC cells treated with bracken fern extracts or purified ptaquiloside. Conclusion Canine and feline urinary bladder UC represent relevant models of MIBC in humans, and cross-species analysis can identify evolutionarily conserved driver genes. We characterize mutational signatures in bovine UC associated with bracken fern and ptaquiloside exposure, a human-linked cancer exposure. Our work demonstrates the relevance of cross-species comparative analysis in understanding both human and animal UC.
View
ResearchGate has not been able to resolve any references for this publication.