This article concerns individual differences in workplace safety behavior. We identify six performance dimensions related to overall safety performance, which in turn, leads to occupational accidents and injuries. We define these dimensions and develop personality-based safety scales to predict them by combining facets of Five-Factor Model scales. Next, we validate these safety scales by aggregating results from independent criterion-related studies and show that a composite safety scale is more predictive of overall safety performance than individual Five-Factor Model scales. Also, results show that safety scales predict accidents and injuries, but this relationship is mediated by safety performance. We consider implications of using individual differences to study links between personality, safety performance, and accidents and injuries in selection, training, and organizational safety culture.