ArticlePDF Available

ALOE VERA: A REVIEW OF ITS CLINICAL EFFECTIVENESS

DOI:10.7897/2230-8407.04812
Authors:
Malik Itrat at National Institute of Unani Medicine
Malik Itrat
Zarnigar
Zarnigar
Zarnigar
  • This person is not on ResearchGate, or hasn't claimed this research yet.
Download full-text PDFDownload full-text PDF
Read full-text
Download citation

Abstract

Aloe vera has been used for over five thousand years. Throughout history, it has been considered a magical plant, almost a panacea, capable of remedying many of mankind’s ailments. It is only in the last 20 years, after a series of proven research, that we can highlight the characteristics of this plant, whose secrets have been hidden behind a blanket of botanical and pharmacological puzzles that only today begin to yield some answers. The Aloe vera plant and its clinical uses are briefly reviewed in this article.
1936_p
df.pdf
Content uploaded by Malik Itrat
Author content
All content in this area was uploaded by Malik Itrat on Nov 06, 2020
Content may be subject to copyright.
ALOE VERA: A REVIEW OF ITS CLINICAL EFFECTIVENE
SS.pdf
Available via license: CC BY-NC-ND 4.0
Content may be subject to copyright.
A preview of the PDF is not available
... The Egyptians called Aloe "the plant of immortality." Today, the Aloe vera plant has been used for various purposes in dermatology, National Institutes of Health Suggests [6] . Aloe vera grows in a clump. ...
Effectiveness of Aloe Vera gel application on the treatment of intravenous phlebitis among patients receiving intravenous therapy at tertiary hospitals of Gangtok, Sikkim
Article
  • Jan 2023
Introduction: Intravenous infusion is the organization of liquid or medicine intravenously in intense conditions for impact. Phlebitis is one of the foremost common complications of intravenous treatment. Around 80% of hospitalized patients are given intravenous infusion therapy at a point admit their remain in a advanced medical facility. Aloe Vera may be a best known plant utilized for treating skin wounds, but it has few other uses that could potentially benefit health. Objective: To evaluate the effectiveness of Aloe Vera gel application among patients with IV phlebitis. Methods: Quasi Experimental study was conducted among 60 hospitalized patients who developed intravenous phlebitis. Purposive sampling technique was used and randomly assigned to the experimental and control groups that met the inclusion criteria. On the first day, a VIP score was used to determine the degree of phlebitis, and then the Aloe Vera gel was applied twice a day for three days in the experimental group and once a day in the control group. On the fourth day, both groups received post-test evaluations using the same scale. Results: The mean post test IV phlebitis score (3.07± 2.477) which was less than the mean pre-test score (9.40 ± 2.673) with a mean difference of 6.33 & t value ( t=8.250 at df = 29) was statistically significant at the p< 0.05 level in the experimental group. In the experimental group, a significant association was found between educational qualification and previous history of any chronic illness in patients with a pre-test level of IV phlebitis (p 0.05). Conclusion: It is concluded that Aloe Vera gel was effective in the treatment of intravenous phlebitis among patients receiving intravenous therapy and can be recommended for use in grade I and II phlebitis.
View
... Aloe vera itself has a unique feature, namely its ability to survive in dry areas during the dry season, by closing its stomata tightly. Thus this plant is very suitable to be cultivated in Indonesia (Malik and Zarnigar, 2013). Parthasarathy et al. (2017) conducted a research related to the qualitative test of phytochemical compounds in Aloe vera extract. ...
Pharmacological Effects and Pharmaceutical Dosage Forms Development of Aloe vera
Article
Full-text available
  • Oct 2021
Tanaman lidah buaya merupakan salah satu tanaman tertua yang digunakan selama ribuan tahun. Lidah buaya telah digunakan sebagai ramuan yang menyembuhkan berbagai penyakit sepanjang sejarah. Sejumlah penelitian yang dilakukan dalam dua dekade terakhir menjelaskan sifat kimia dan senyawa alami yang terkandung dalam tanaman ini, seperti antrakuinon, asam amino, acemannan, aloesin, dan glukomanan, yang menunjukkan efek terapeutik yang beragam. Artikel ini bertujuan untuk meninjau efek farmakologis tanaman lidah buaya dan berbagai bentuk sediaan farmasinya. Data dikumpulkan dari literatur internasional yang diterbitkan di PMID dan Google Scholar. Dapat disimpulkan bahwa lidah buaya memiliki berbagai efek terapi seperti anti inflamasi, penyembuhan luka, anti oksidan, anti kanker, anti tumor, anti tukak, antivirus dan antibakteri, serta anti kolesterol. Selain itu, beberapa formulasi farmasi Aloe vera dapat disiapkan selama pengembangan produk, termasuk supositoria, krim, gel, dan tablet. Kata kunci: Lidah buaya; bentuk sediaan farmasi; efek farmakologis; pengembangan produk. The Aloe vera plant is one of the oldest plants used for thousands of years. Aloe vera has been used as a herb that cures multiple diseases throughout history. Numerous studies conducted in the past two decades shed light on the chemical properties and natural compounds contained in this plant, such as anthraquinone, amino acids, acemannan, aloesin, and glucomannan, exhibiting diverse therapeutic effects. This article aimed at reviewing the pharmacological effects of Aloe vera plant and its different pharmaceutical dosage forms. Data were collected from international published literature in PMID and Google Scholar. It can be concluded that the Aloe vera has various therapeutics effects such as anti-inflammatory, wound healing, anti-oxidant, anticancer, anti-tumor, antiulcer, antiviral and antibacterial, and anti-cholesterol. In addition, some pharmaceutical formulations of Aloe vera can be prepared during product development, including suppositories, creams, gels, and tablets.
View
... As examples, among the ingredients of more common use are: Ascorbic acid (vitamin C), utilized for its antioxidant properties in the pigment-lightening formulations together with alpha lipoic acid, arbutin and Kojic acid [42]; aloe vera, which finds applications for its antibacterial, antiviral and immune modulating effectiveness [43]; grape seed oil, used as anti-aging agent thanks to its antioxidant and healing properties [44]; and green and black tea rich in antioxidant and antibacterial molecules, which are also able to inhibit the virus entry [45]. Some selected natural ingredients of common use in the cosmetic field and obtained from waste, micro algae and bacteria are reported in Table 1 as an example [46][47][48][49][50][51][52][53][54][55][56], while the more used ones, such as hyaluronic acid, oligopeptides, biomimetic peptides and collagen, are described reporting their supposed mechanism of action. ...
Active Ingredients and Carriers in Nutritional Eco-Cosmetics
Article
Full-text available
  • Jan 2023
Beauty and personal care became a significant part of the global economy for two reasons: (1) The elderly growing in the global population and (2) the desire of women and men to appear younger and more attractive. Thus, both young and old people are looking for revolutionary nutritional eco-cosmetics (combined use of cosmeceuticals and nutraceuticals) manufactured by natural active ingredients, using biopolymers as substrates, and made by innovative and sustainable technologies. Consequently, the market of both cosmetics and diet supplements is continually growing together with the request of natural active ingredients, including bio-peptides and biological macromolecules such as chitin and lignin. Therefore, both consumers and industry need to recover innovative active ingredients and carriers (vehicles), naturally derived and supported by advanced methods for controlling their effectiveness and safeness on skin and mucous membrane layers. The use of selected bio-ingredients, such as hyaluronic acid and bio-mimetic peptides, obtained by advanced, innovative and sustainable bio nanotechnologies, will be of interest to develop smart cosmeceutical and nutraceutical formulations. Innovation is considered the key business strategy to drive sustainable economic growth. For trying to reduce waste and produce sustainable, biodegradable and innovative products, the realization of new non-woven tissues, used as carriers for making innovative cosmeceuticals and nutraceuticals was considered. Both carriers and active ingredients have been obtained from food waste to reduce loss and pollution. This review will report a brief description of the skin functions, trying also to focus and discuss some of the active ingredients and carriers used in nutritional eco-cosmetics to clarify the supposed mechanism of action, effectiveness and safeness of both active ingredients and carriers, as well as the supposed activity of beauty and personal care products.
View
... Succulent plants are water-retaining plants, which can store water in their leaves, stems, and roots to survive in a dry environment. Aloe barbadensis Miller (Aloe Vera), Beschorneia and Sansevieria plants belong to succulent family [39,40]. These plants can grow in tropical, sub-tropical, warmer temperature regions, and exchange the oxygen and CO 2 using CAM process at night. ...
Plant Base Renewable Energy to Power Nanoscale Sensors
Chapter
Full-text available
  • Nov 2022
The modern technologies have been revolutionized due to tremendous progress in Internet-of-Things (IoT). Sensors are a core component to make a bridge between the Internet and surrounding environments. The progress in power efficient communication network makes it possible to deploy the sensors in remote areas. The major drawback of these sensors is that they use Li-ion battery for power supply, which needs frequent recharging/replacement due to massive number of connected devices to IoT. The hazardous chemicals left in environment after the use of battery is another concern. Since modern nanoscale sensors need only nanoscale power (of order of μWatt), nanogenerators can play an important role to provide self-powered sensors, which is growing technology that can harvest small-scale energy from piezo- and pyroelectric effect. However, this technique is lightweight but not cost-effective and biodegradable. We have proposed a green, sustainable energy harvesting system based on living plants because plants are the undisputed champion of solar power that operates at nearly 100% efficiency. Plant-based energy generation is a method that harvests electrical energy from living plants due to a chemical reaction between the plant and a pair of electrodes. This energy is available 24×7 day and night irrespective of environmental conditions.
View
Formulation and evaluation of anti-acne face cream
Article
Full-text available
  • Jul 2023
Now a day’s the majority of Indians are affected by the persistent skin illness known as acne vulgaris. Sebaceous glands are involved in the chronic inflammatory skin condition known as acne. Propionibacterium acnes (P. acne), altered follicular keratinization, inflammation, and androgen-induced enhanced sebum hyper-production are four primary pathophysiology. Due to their minimal adverse effects, many now prefer using herbal products over synthetic ones. We create the anti-acne face cream using ingredients like Manjishtha, Aloe Vera, and almond oil. Indian madder, also known as Rubia cordifolia, is found close to streams and rivers. It contains additional qualities including anti-ageing, anti-inflammatory, antibacterial, etc. and is typically used to treat acne. Almond oil is filled with vitamin E, and aloe vera is advantageous and mostly used to cure skin conditions. Certain evaluation test are performed to check whether cream suitable for human skin, its checks whether cream cause the irritancy after applying to skin or not.
View
FORMULATION AND EVALUATION OF ALCOHOL BASED HERBAL HAND SANITIZER
Article
Full-text available
  • May 2023
The aim of the present work was to prepare an alcohol based herbal hand sanitizer. This sanitizer was prepared by using herbal oils such as eucalyptus oil, lemongrass oil, clove oil and aloe vera gel including other excipients. The sanitizer was formulated by the dispersion method. The excipients which were used included denatured alcohol, Carbopol 940, polysorbate 20, glycerine, triethanolamine and preservatives. This study was aimed to prepare an alcohol based herbal hand sanitizer for antimicrobial purpose. The pH of sanitizer was found to be between 6.56 to 6.67. The viscosity of sanitizer was found to be between 376 to 838. The spread ability was good and found in range between 6.33 to 7.16. The drug content of Eucalyptus Oil in formulations was found to be 89.8% in F1, 93% in F2 and 97.4% in F3 and the drug content of Lemongrass Oil in formulations was found to be 87% in F1, 88% in F2 and 90% in F3. In-vitro drug release study was found to be 52.6% in F1, 35.2% in F2 and 62.65 in F3. The Anti-microbial study of the formulation was done against the standard drug (Streptomycin) and found to be effect and the Stability of the formulations was found to be stable upon storage for 3 months. All these studies have revealed that the formulation F3 is best because it has better pH, Viscosity, spread ability, Drug content, In-vitro drug release study, Anti-microbial study and Stability.
View
Synthesis of Medicinal Agents from Plants
Book
Full-text available
  • Sep 2022
This book is an effort to throw light on the importance of biologically active molecules which are isolated from different plants, their biological activity, extraction from natural sources and their in vivo production to preserve the biodiversity of medicinal plants.
View
Herbal hair oil: A review
Article
Full-text available
  • Jun 2022
Beauty and cosmetic concept is as ancient as mankind and civilization. Cosmetics play a vital role in human life. Herbal cosmetic is one of the most effective areas of cosmetic technology. Herbal cosmetics are developed by the coalition of bioactive ingredients and pharmaceutical products. Herbs are used for beautification purpose of body, preparation of cosmetics, flavouring and colouring agent. Hair plays a vital role in personality of human and we use a lots of cosmetics product for the care of hair. The study aims reviewing the importance of herbal oil and their use in the common hair problem such as baldness, hair fall, hair dryness, dandruff etc. Various beauty and cosmetic products are used which contain herbs to give young and charming look. Various herbal ingredients are used in herbal hair formulation; they provide essential nutrients such as vitamins, antioxidant, etc. Herbal hair oil has been widely used for nourishment of hair and for the protection of hair from hair fall and hair damage. Now a day’s side effect is a major problem after using any beauty product due to which herbal products are preferred because of having less probability of any types of side effects.
View
PHYTOCHEMICAL AND ETHNOBOTANICAL EFFECTS OF ALOE VERA
Article
Full-text available
  • Oct 2021
Aloe vera is part and parcel of the Liliaceae family. This is one of 250 Aloe Barbadensis species, scientifically known as Aloe Vera. Acemannane, one of the most bioactive polysaccharides of Aloe Vera, has effects of immunity modulation, anti-cancer, anti-oxidation, bone repair, neuroprotection and promotion of intestinal health. The mucilaginous gel in the pulp of aloe vera formed by the parenchymal cells has been used for a variety of curative applications since ancient times. Aloe vera is a nutraceutical product used mostly for decades. It is available in a range of health drinks and wellness beverages, in capsules/tablets and in gels & creams externally. This article includes the bioactive components, extraction and processing of aloe vera and the prospects of tissue engineering. This article highlights important uses as a nutraceutical, medicinal, and therapeutic food potential of A. vera constituents. Aloe vera nutraceutical gel scaffolds, such as acemannan, promote biomedical biomedical and polymeric tissue management. The presence of over 200 phytochemicals was revealed by Aloe vera gel. Aloe vera gel from its leaves is extracted and the stabilisation and preparation of the final products requires adequate processing techniques.
View
The Chemical Constituents, Anti-Inflammatory, Anti-Oxidant, and Ethnomedicinal Properties of Aloe barbadensis
Chapter
  • Jan 2022
Aloe vera is a perennial, drought-resisting, succulent plant belonging to the Asphodelaceae family that has a long history of having many tremendous medicinal and anti-inflammatory as well as anti-bacterial properties. This chapter highlights the great potentials of the aloe vera species. Desk study and document analysis guided the systematic and extensive review of both published and unpublished resources on the Aloe vera Species. The chapter contends that horticulturists and plant scientists in the field of agriculture and medicine must pay attention to the Aloe vera as a medicinal plant that possesses the most powerful antibacterial and anti-inflammatory properties, which protects the body against constipation through enhancing the body metabolism, skin, and worm infestations.
View
Aloe vera: A short review
Article
Full-text available
  • Feb 2008
Aloe vera is a natural product that is now a day frequently used in the field of cosmetology. Though there are various indications for its use, controlled trials are needed to determine its real efficacy. The aloe vera plant, its properties, mechanism of action and clinical uses are briefly reviewed in this article.
View
Inhibition of benzo[a]pyrene-DNA adduct formation by Aloe barbadensis Miller
Article
Full-text available
  • Apr 1997
The antigenotoxic and chemopreventive effect of Aloe barbadensis Miller (polysaccharide fraction) on benzo[a]pyrene (B[a]P)-DNA adducts was investigated in vitro and in vivo. Aloe showed a time-course and dose-dependent inhibition of [3H]B[a]P-DNA adduct formation in primary rat hepatocytes (1x10(6) cells/ml) treated with [3H]B[a]P (4 nmol/ml). At concentrations of 0.4-250 microg/ml aloe, the binding of [3H]B[a]P metabolites to rat hepatocyte DNA was inhibited by 9.1-47.9%. Also, in rat hepatocytes cultured for 3-48 h with aloe (250 microg/ml) and [3H]B[a]P (4 nmol/ml), [3H]B[a]P-DNA adducts were significantly reduced by 36% compared with [3H]B[a]P alone. Aloe also inhibited cellular uptake of [3H]B[a]P in a dose-dependent manner at a concentration of 0.4-250 microg/ml by 6.3-34.1%. After a single oral administration of B[a]P to male ICR mice (10 mg/mouse), benzo[a]pyrene diol epoxide I (BPDE-I)-DNA adduct formation and persistence for 16 days following daily treatment with aloe (50 mg/mouse) were quantitated by enzyme-linked immunosorbent assay using monoclonal antibody 8E11. In this animal model, BPDE-I-DNA adduct formation was significantly inhibited in various organs (liver, kidney, forestomach and lung) (P < 0.001). When mice were pretreated with aloe for 16 days before B[a]P treatment, inhibition of BPDE-I-DNA adduct formation and persistence was enhanced. Glutathione S-transferase activity was slightly increased in the liver but cytochrome P450 content was not affected by aloe. These results suggest that the inhibitory effect of aloe on BPDE-I-DNA adduct formation might have a chemopreventive effect by inhibition of B[a]P absorption.
View
Antibradykinin Active Material in Aloe saponaria
Article
A material having antibradykinin activity on isolated guinea pig ileum was partially purified from the nondialysate of the pulp of Aloe saponaria by repetition of gel chromatography using a hydrophilic polyvinyl gel and dextran gels. From the results of amino acid and carbohydrate analyses, the antibradykinin-active material was estimated to be a glycoprotein. It was found that this material catalyzes the hydrolysis of bradykinin at pH 7.4. The results of peptide analysis using reversed-phase high-performance liquid chromatography coupled with amino acid analysis indicate that this glycoprotein cleaves the Gly4-Phe5 and Pro7-Phe8 bonds of the bradykinin molecule.
View
Influence of Aloe Vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats
Article
The influence of Aloe vera (L.) Burman f. on the glycosaminoglycan (GAG) components of the matrix in a healing wound was studied. Wound healing is a dynamic and complex sequence of events of which the major one is the synthesis of extracellular matrix components. The early stage of wound healing is characterized by the laying down of a provisional matrix, which is then followed by the formation of granulation tissue and synthesis of collagen and elastin. The provisional matrix or the ground substance consists of GAGs and proteoglycans (PGs), which are protein GAG conjugates. In the present work, we have studied the influence of Aloe vera on the content of GAG and its types in the granulation tissue of healing wounds. We have also reported the levels of a few enzymes involved in matrix metabolism. The amount of ground substance synthesized was found to be higher in the treated wounds, and in particular, hyaluronic acid and dermatan sulphate levels were increased. The levels of the reported glycohydrolases were elevated on treatment with Aloe vera, indicating increased turnover of the matrix. Both topical and oral treatments with Aloe vera were found to have a positive influence on the synthesis of GAGs and thereby beneficially modulate wound healing.
View
View
Nitric oxide production by chicken macrophages activated by acemannan, a complex carbohydrate extracted from Aloe Vera
Article
Cultures of normal chicken spleen cells and HD11 line cells produce nitric oxide (NO) in response to Acemannan, a complex carbohydrate derived from the Aloe vera plant. Neither cell type produced detectable amounts of NO in response to similar concentrations of yeast mannan, another complex carbohydrate. Nitric oxide production was dose dependent and inhibitable by the nitric oxide synthase inhibitor NG-methyl-L-arginine. In addition, the production of NO was inhibited by preincubation of ACM with concanavalin A in a dose-dependent manner. These results suggest that ACM-induced NO synthesis may be mediated through macrophage mannose receptors, and macrophage activation may be accountable for some of the immunomodulatory effects of ACM in chickens.
View
Antiinflammatory C -Glucosyl Chromone from Aloe barbadensis
Article
  • Jun 1996
A new antiinflammatory agent identified as 8-[C-beta-D-[2-O-(E)-cinnamoyl]glucopyranosyl]-2- [(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 microg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 microg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 microg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.
View
Beneficial Effect of Aloe on Wound Healing in an Excisional Wound Model
Article
  • Feb 1996
Recent evidence from in vitro and in vivo experiments suggests that topical antimicrobials may be toxic to fibroblasts and keratinocytes and retard wound healing. The purpose of this study was to determine the effects of Aloe, a potential wound-healing agent, on wound contraction in excisional wounds treated with topical antimicrobials. Sprague-Dawley rats were prepared with four 1.5 cm2 dorsal defects through the skin and panniculus. The animals were divided into five groups (n = 10 per group): (1) Aloe, (2) NaOCl solution (0.025%), (3) mafenide acetate, (4) mafenide acetate + Aloe, and (5) control. Wounds were treated topically for 14 days 3 times a day. Serial standard photographs and serial wound planimetry were performed weekly. Following healing, the breaking strength of each resultant scar was determined using an Instron tensiometer. Kruskal-Wallis, ANOVA, and multiple comparison methods were used for data analysis. Aloe and NaOCl solution significantly accelerated wound contraction (p < 0.05). In the mafenide acetate + Aloe group, contraction was similar to the control, whereas the mafenide acetate alone retarded wound healing. The addition of Aloe in combination and alone in wounds increased the breaking energy when compared to controls (p < 0.05). Aloe appears to expedite wound contraction and neutralize the wound retardant effect seen with the topical mafenide acetate alone. This effect appears to be due to an increased collagen activity, which is enhanced by a lectin, consequently improving the collagen matrix and enhancing the breaking strength.
View
Influence of Aloe Vera on collagen characteristics in healing dermal wound in rats
Article
  • May 1998
Wound healing is a fundamental response to tissue injury that results in restoration of tissue integrity. This end is achieved mainly by the synthesis of the connective tissue matrix. Collagen is the major protein of the extracellular matrix, and is the component which ultimately contributes to wound strength. In this work, we report the influence of Aloe vera on the collagen content and its characteristics in a healing wound. It was observed that Aloe vera increased the collagen content of the granulation tissue as well as its degree of crosslinking as seen by increased aldehyde content and decreased acid solubility. The type I/type III collagen ratio of treated groups were lower than that of the untreated controls, indicating enhanced levels of type III collagen. Wounds were treated either by topical application or oral administration of Aloe vera to rats and both treatments were found to result in similar effects.
View
Evaluation of Aloe vera gel gloves in the treatment of dry skin associated with occupational exposure
Article
An examination glove that delivers aloe vera (AV) gel to the gloved hand was studied in 30 adult females with bilateral occupational dry skin with or without irritant contact dermatitis (with or without erythema, fissures, and excoriations). All participants were factory assembly-line workers with repeated superficial skin trauma who attributed their dry, irritated, emollient-dependent skin to a common cause (occupational exposure). Participants were sequentially enrolled (after written informed consent, n = 29 evaluable participants) into an open, contralateral comparison study to evaluate efficacy of AV glove use 8 h/day to one hand versus no use to the opposite hand for 30 days, followed by 30 days rest, followed by 10 days of repeated use. Participant's dorsal hands were documented by standardized photos at baseline, during, and at the end of study. Unblinded investigator baseline assessment rated dry skin as mild to moderate (n = 27), or moderate to severe (n = 2). Mean time to noticeable improvement for the AV glove hand was 3.5 days (range: 2-6 days) whereas marked improvement was 10.4 days (range: 7-17 days) for the AV glove hand. No improvement was detected for nonglove hands. Blinded photo assessment was rated independently by dermatology research staff. End-of-study mean global assessment of AV glove hands versus nonglove hands was 1.3 for AV glove hand (0 = no change, 1 = good [10%-89% global improvement], 2 = marked improvement [90%-100% global improvement]) versus 0 for nonglove hand (P <.0001). Mean global end-of-study assessments by the participants = 2.0 for AV glove hand versus 0 for nonglove hand. Dry-coated AV gloves that provide for gradual delivery of AV gel to skin produced a uniformly positive outcome of improved skin integrity, decreased appearance of fine wrinkling, and decreased erythema in the management of occupational dry skin and irritant contact dermatitis.
View