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Pharmacological basis for the medicinal use of cardamom in asthma



Cardamom (Elettaria cardamomum) is widely used in folk medicine for the treatment of asthma. This study describes its airways relaxant potential, with elucidation of possible underlying mechanism. Crude extract of cardamom which tested positive for alkaloids, flavonoids, saponins, sterols and tannins, when tested against carbachol-mediated bronchoconstriction in rats under anesthesia, dose-dependently (10-100 mg/kg) suppressed the carbachol (1 mu mol/kg)-evoked increase in the inspiratory pressure. In isolated rabbit trachea tissues, crude extract of cardamom caused relaxation of both carbachol (1 mu M) and high K+ (80 mM)-induced contractions, like that caused by verapamil, suggesting its Ca++ channel blockade action. These results indicate that cardamom exhibits bronchodilatory effect, mediated through Ca++ antagonist mechanism, which provides sound mechanistic background for its medicinal use in asthma.
Elettaria cardamomum Maton (family: Scitaminaceae)
commonly known as “cardamom” and locally known
as “elaichi” is a perennial herb, indigenous to India,
Pakistan, Burma and Sri Lanka (Nadkarni, 1976). In
addition to its wide use for culinary purpose,
cardamom has been used in traditional medicine for
asthma, constipation, colic, diarrhea, dyspepsia,
hypertension, epilepsy and is considered useful as
antibacterial, antifungal, antiviral, carminative, diuretic
and stomachic (Kapoor, 1990; Duke et al., 2002).
Phytochemical studies revealed that cardamom
contains α-terpineol, myrcene, heptane, subinene,
limonene, cineol, menthone, α-pinene, β-pinene, linalol,
nerolidol, β-sitostenone, phytol, eugenyl acetate,
bisabolene, borneol, citronellol, geraniol, geranyl
acetate, stigmasterol and terpinene (Gopalakrishnan et
al., 1990; Duke, 1992). Despite the fact that cardamom
has been used medicinally, it has not been widely
studied to rationalize its use in hyperactive status of
airways, asthma. In this study, we evaluated that the
bronchodilatory effect of cardamom is mediated
through Ca++ channel blockade, which provide
pharmacological rational for its effectiveness in the
Materials and Methods
Plant material and preparation of extract: Dried fruits of
cardamom were purchased from a local market in
Karachi and the sample voucher (EC-SE-07-04-54) was
submitted to the Department of Biological and
Biomedical Sciences herbarium, Aga Khan University,
Karachi. After cleaning of adulterant material, the fruits
were ground with an electric grinder into a coarse
powder. Extraction and fractionation was carried out as
described previously. About 986 g of ground material
A Journal of the Bangladesh Pharmacological Society (BDPS) Bangladesh J Pharmacol 2011; 6: 34-37
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ISSN: 1991-007X (Print); 1991-0088 (Online); DOI: 10.3329/bjp.v6i1.8133
Pharmacological basis for the medicinal use of cardamom in
Arif-ullah Khan1,2, Qaiser Jabeen Khan1,3 and Anwarul-Hassan Gilani1
1Natural Product Research Division, Department of Biological and Biomedical Sciences, Aga Khan University
Medical College, Karachi 74800, Pakistan; 2Institute of Pharmaceutical Sciences, Kohat University of Science and
Technology, Kohat 26000, Pakistan; 3Faculty of Pharmacy and Alternative Medicine, The Islamia University of
Bahawalpur 63100, Pakistan.
Cardamom (Elettaria cardamomum) is widely used in folk medicine for the
treatment of asthma. This study describes its airways relaxant potential, with
elucidation of possible underlying mechanism. Crude extract of cardamom
which tested positive for alkaloids, flavonoids, saponins, sterols and tannins,
when tested against carbachol-mediated bronchoconstriction in rats under
anesthesia, it dose-dependently (10-100 mg/kg) suppressed the carbachol (1
µmol/kg)-evoked increase in the inspiratory pressure. In isolated rabbit
trachea tissues, crude extract of cardamom caused relaxation of both carbachol
(1 µM) and high K+(80 mM)-induced contractions, like that caused by
verapamil, suggesting its Ca++ channel blockade action. These results indicate
that cardamom exhibits bronchodilatory effect, mediated through Ca++
antagonist mechanism, which provides sound mechanistic background for its
medicinal use in asthma.
Article Info
Received: 30 July 2011
Accepted: 1 August 2011
Available Online: 3 August 2011
Ca++ channel blocker
Number of Figures: 2
Number of Refs: 14
Correspondence: AHG
This work is licensed under a Creative Commons Attribution 3.0 License. You are free to copy, distribute and perform the work. You must attribute
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was soaked in 4 liters of the aqueous-methanol (70%)
for three days with occasional shaking. It was filtered
through a muslin cloth and then through a Whatman
qualitative grade 1 filter paper. This procedure was
repeated twice and the combined filtrates were
evaporated on rotary evaporator under reduced
pressure (-760 mmHg) to a thick, semi-solid pasty mass
of dark brown color; i.e. the crude extract of cardamom,
yielding approximately 10.81%, soluble in saline/
distilled water.
Animals: Animals used in this study, such as Sprague-
Dawley rats (230-260 g) and rabbits (1.5-2.0 kg) of either
sex and local breed were housed at the Animal House
of the Aga Khan University, maintained at 23-25 C.
Experiments performed complied with the rulings of
the Institute of Laboratory Animal Resources,
Commission on Life Sciences, National Research
Council (1996) and approved by Ethical Committee of
Aga Khan University.
Chemicals: Carbachol, salbutamol and pentothal sodium
(thiopental sodium) were respectively obtained from
Sigma Chemicals Co., St. Louis, MO, USA, Glaxo
Wellcome and Abbot Laboratories, Karachi, Pakistan.
Chemicals for Krebs solutions include: potassium
chloride (Sigma Chemical Company), calcium chloride,
glucose, magnesium sulphate, potassium dihydrogen
phosphate, sodium bicarbonate and sodium chloride (E.
Merck, Darmstadt, Germany). The chemicals used in
phytochemical analysis include: acetic anhydride,
al um in um chloride, ammonium hy dr ox id e,
dragendorff's reagent, ferric chloride (Sigma Chemical
Co, St Louis, MO, USA), benzene, chloroform,
hydrochloric acid and petroleum ether (BDH
Laboratory supplies, Poole, England). All the chemicals
used were of analytical grade available.
Phytochemical screening: Preliminary screening of the
plant extract for various phytochemical classes was
carried out following the reported methods (Gilani et
al., 2007). Alkaloids were tested by using Dragendorff’s
reagent. Appearance of yellow color with AlCl3reagent
and green or black with aqueous FeCl3 detects
flavonoids and tannins respectively. Plant material
treated with petroleum ether and subsequently
extracted with CHCl3 was noted for green to pink or
pink to purple color after reaction with acetic anhydride
and HCl in succession to detect sterols and terpenes
respectively. Saponins were detected on the basis of
froth upon vigorous shaking. The observation of yellow
florescence under UV light on filter paper impregnated
with the vapours from boiling extract indicates the
presence of coumarins. Benzene extract prepared from
acidified plant material was treated with NH4OH for
anthraquinones based on the appearance of pink, violet
or red color.
Bronchodilatory activity: Rats were anaesthetized with
sodium thiopental (Pentothal, 80-100 mg/kg, i.p.), than
incubated with a tracheal tube and ventilated with a
volume ventilator (Miniature ideal pump, Bioscience,
UK) adjusted at a rate of 70-80 strokes/min to deliver 7-
10 mL/kg of room air. A polyethylene catheter was
inserted into the jugular vein for drugs administration.
Changes in airways resistance (mmHg) were measured
by a pressure transducer (MLT-1199) connected to side
arm of tracheal cannula and recorded by PowerLab
4/25 with running chart software via Quad bridge
amplifier (ADInstruments, Bella Vista, NSW, Australia).
Bronchoconstriction was induced with carbachol (1
µmol/kg), which was reversed within 7-10 min. The
test drug was given to the animals 5-8 min prior to
administration of carbachol. The responses were
expressed as the percent reduction of the carbachol-
evoked bronchospasm (Khan and Gilani, 2009).
Isolated rabbit trachea: Tr ach ea fr om rab bi t,
sacrificed by blow on back of head was dissected out
and kept in Kreb’s solution. The tracheal tube was cut
into rings, 2-3 mm wide, each containing about two
cartilages. Each ring was opened by a longitudinal cut
on ventral side, forming a tracheal chain with smooth
muscle in the center and cartilaginous portions on the
edges Each preparation was then mounted in 20 mL
tissue bath containing Kreb’s solution, maintained at
37ºC and aerated with carbogen (5% CO2in 95% O2).
The composition of Kreb’s solution was (mM): NaCl
118.2, NaHCO325.0, CaCl22.5, KCl 4.7, KH2PO41.3,
MgSO41.2 and glucose 11.7 (pH 7.4). A tension of 1 g
was applied to each of the tracheal strip and was kept
constant throughout the experiment. The tissue was
equilibrated for 1 hr before the addition of any drug.
Then sustained contractions of the agonists, carbachol
(1 µM) and/or K+ (80 mM) were obtained and tracheo-
relaxant effect of the test material was assessed by
adding in a cumulative fashion. Carbachol is a
c h o l i ne rgi c a gon i s t , k n o wn t o c a u s e
bronchoconstriction via stimulation of muscarinic
receptors (Gilani et al., 2010). High K+(> 30 mM) is
known to cause smooth muscle contractions through
opening of voltage-dependent L-type Ca++ channels,
thus allowing influx of extracellular Ca++ causing a
contractile effect and the substance causing inhibition of
high K+-induced contraction is considered as inhibitor
of Ca++ influx (Godfraind et al., 1986). The changes in
isometric tensions of the tracheal strips were measured
via a force-displacement transducer (FT-03) using a
Grass model 7 Polygraph (Grass Instrument Company,
Quincy, MA, USA).
Bangladesh J Pharmacol 2011; 6: 34-37 35
Statistical analysis: The data expressed are mean
standard error of mean (SEM, n=number of experiment)
and the median effective concentrations (EC50) with
95% confidence intervals (CI), analyzed by using
GraphPad program (GraphPAD, San Diego, CA, USA).
Crude extract of cardamom was found to contain
alkaloids, flavonoids, saponins, sterols and tannins
while tested negative for the rest of classes (data not
Crude extract of cardamom at the doses of 10, 30 and
100 mg/kg caused 9.0 2.1, 37.7 5.4 and 83.4 4.4%
(n=4) respective inhibition of carbachol (1 µmol/kg)-
evoked increase in inspiratory pressure of
anaesthetized rats. Salbutamol suppressed the
carbachol (1 µmol/kg)-induced bronchoconstriction at
0.3 mg/kg by 78.7 3.9% (n=4; Figure 1).
In tracheal preparations, pre-contracted with carbachol
(1 µM) and K+ (80 mM), crude extract of cardamom
caused concentration-dependent relaxant effect, being
more potent against K+, with respective EC50 values of
0.85 (0.6-1.3, 95% CI, n=5) and 0.37 mg/mL (0.32-0.43,
n=4; Figure 2A). Verapamil also caused inhibitory
effect, possessing higher potency against K+, with EC50
values of 0.26 (0.18-0.33, n=3) and 0.09 µM (0.06-0.14,
n=3) respectively (Figure 2B).
In view of the well known medicinal use in asthma, the
cardamom was tested for its possible bronchodilatory
effect in anaesthetized rats, where it inhibited the
carbachol-evoked bronchospasm, like that caused by
salbutamol, a standard bronchodilator (Barnes, 2006).
Figure 1: Bar chart showing inhibitory effect of the crude extract
of cardamom and salbutamol on the carbachol-mediated
bronchoconstriction in anesthetized rats. Values shown are
mean ± SEM, n=4
10 30 100 0.3
Crude extract of cardamom
% of Carbachol (1 mol/kg)-induced
Inspiratory Pressure
Figure 2: Concentration-dependent inhibitory effect of (A)
crude extract of cardamom and (B) verapamil against
carbachol and high K+-induced contractions in isolated rabbit
tracheal preparations. Values shown are mean ± SEM, n=3-5
0.03 0.3 3
Carbachol (1 M)
K+ (80 mM)
[Crude extract of cardamom] mg/mL
% of Induced Contraction
0.003 0.03 0.3 3
Carbachol (1 M)
K+ (80 mM)
[Verapamil] M
% of Induced Contraction
36 Bangladesh J Pharmacol 2011; 6: 34-37
The cardamom extract was then studied in isolated
tracheal tissues, to elucidate the possible mode of
bronchodilator action, where crude extract of
cardamom caused relaxation of both carbachol and K+-
induced contractions, like verapamil, a Ca++ antagonist
(Fleckenstein, 1977) used as positive control. High K+
and carbachol are known to cause smooth muscle
contractions through opening of L-type Ca++ channel
and stimulation of muscarinic receptors respectively,
eventually leading to an increase in the intracellular
Ca++ level, resulting in airways constriction (Gilani et
al., 2007). The inhibitory effect of crude extract of
cardamom against the two spasmogens, indicates non-
specific tracheao-relaxant effect, mediated through Ca++
channel blocker-like mechanism (Gilani et al., 2010).
Ca++ antagonists are known to be effective in asthma
(Twiss et al., 2002) and the presence of such activity, as
observed in this study may explain the medicinal use of
cardamom in such disorder of airways hyperactivity.
The results of phytochemical analysis showed that
cardamom contains alkaloids, flavonoids, saponins,
sterols and tannins. The flavonoids are well known for
their bronchodilatory activity (Ghayur et al., 2007) and
the presence of such class of compounds in cardamom
is likely to contribute in its airways relaxing action.
However, the contribution of other constituents cannot
be ignored.
In conclusion, cardamom exhibits bronchodilatory
effect, mediated through Ca++ antagonist mechanism,
which provides pharmacological basis for its
application in the disorder of hyperactive status of
respiratory system, known as asthma.
This study was supported by funds made available by
Pakistan Science Foundation.
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... Bioenhancer activity of cardamom. The essential oil obtained from cardamom acts as a bioenhancer by increasing the glutathione-S- transferase (GST) and decreasing lipid per oxidation [33][34][35][36][37] as shown in Fig. 2(B). 38 Some of the reported bioenhancer activity of cardamom is listed in Table 3. ...
Spices are natural plant products enriched with the history of being used as herbal medicine for prevention of diseases. India is also known as "Land of Spices". Out of 109 spices recognized by the International Organization for Standardization (ISO) world more than 52-60 spice crops are grown in India. The major spices exported by India are Turmeric, Cumin, Coriander, Fenugreek, Peppers etc. The Indian spices are divided into three era viz. early period, middle age and early modern period. Spices are used in beverages, liquors, and pharmaceutical, cosmetic and Perfumery products. The major issue with spices is their handling and storage. This review article mainly focuses on two aspects: At the outset the handling and storage of the spices is essential factor as spices are available in different forms like raw, processed, fresh, whole dried, or pre-ground dried. So the need of processing, packaging, storage and handling of the spices is important as spices deterioration can leads to the loss of its therapeutic activity. Furthermore many herbal constituents have the capability to enhance the bioavailability of drugs. So an attempt has been made to throw a light on the bio enhancer activity and therapeutic activity along with their mechanism of action of the some Indian Spices which are regularly used for cooking purpose on the daily basis to enhance the taste of food. The spices suggested by ministry of AYUSH which is relevant to its medicinal and biological property in treatment and prevention from COVID-19 are discussed. This article is protected by copyright. All rights reserved.
... Cardamom blossoms develop on leafless shoots from the rhizome; the fruit is a capsule usually 7 mm in size with a green color, containing many highly aromatic black seeds with capsules round or long, but they all have the same taste and properties [18]. Traditional medicine has used cardamom capsules, as popular remedies to treat many conditions, cardiac and kidney disorders, teeth and gum infections, nausea, diarrhea, asthma and digestive disorders [19][20][21]. In recent years, E. cardamomum has been found to possess biological activities, such as gastric antiulcerogenic [22] anti-inflammatory [23], antidiarrhoeal [24], antidiabetic [25] and antimutagenic [19]. ...
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The aim of this work was to study the chemical composition of the essential oil extracted from ginger rhizomes (Zingiber officinale Roscoe) and cardamom seeds (Elettaria cardamomum (L.) Maton). Using gas chromatography coupled with mass spectrometry (GC/MS), a total of 43 compounds were identified in ginger essential oil and 17 compounds in cardamom. The most abundant components, respectively, were zingiberene (22.18%) and 1.8-cinéol (43.47%). Essential oils, metha-nol, ethanol and chloroform extracts for both plants were tested against nine bacteria and yeast. The highest sensitivity was noticed against Staphylococcus aureus with a 25 mm inhibition zone. The an-tioxidant potency of both oils and extracts were measured using DPPH (1,1-diphenyl-2-picryl hy-drazyl) free radical scavenging and the ferric reducing power (FRP) method; the ethanolic extract of cardamom fruits exhibited the best results for both tests, with an IC 50 = 0.423 ± 0.015 mg/mL and 95.03 ± 0.076 FRP mg AAE/g.
... Kardamon jest stosowany głównie w dolegliwościach układu pokarmowego (niestrawność, kolki, brak apetytu) oraz w schorzeniach dróg oddechowych. Działa też przeciwzapalnie, przeciwbakteryjnie, a blokując kanały wapniowe, pośredniczy w rozszerzaniu oskrzeli, co stanowi uzasadnienie jego skuteczności w astmie (16)(17)(18)(19). ...
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SUMMARY Introduction. Some of the medicinal plants, which are also spices, show multidirectional pharmacological activity resulting from the presence of numerous active compounds, including polyphenols. Spice extracts often have antioxidant properties, and when used to improve the taste of dishes, they also contribute to the prevention and treatment of many civilization diseases. Plants with a potential antioxidant activity are popular spices: cinnamon, ginger, turmeric, nutmeg and cardamom. Aim. Comparison of water and alcohol extracts from five spices in terms of the total phenolic content and antioxidant activity. Material and methods. The study was conducted on the water and methanol extracts from five spices derived from the three producers. The total phenolic content in the extracts was determined by the colorimetric method with the use of the Folin-Ciocalteu (FC). The antioxidant activity was determined by methods with the ABTS •+ radical cation and the reduction of iron (III) ions (FRAP). Results. The total phenolic content in the examined extracts, ranged from 0.74 to 39.32%, expressed as gallic acid. The highest total polyphenol content was determined in cinnamon extracts (29.72-39.32%). The antioxidant properties of the examined extracts were as follows: the IC 50 parameter (for the method with the ABTS •+ radical cation) was from 245.94 to 1.148 (mg/ml), and the IC 0.5 parameter (for the FRAP method) from 91.67 to 0.70 (mg/ml). Conclusions. The content of polyphenolic compounds in the tested extracts differed depending on the type of spice and the preparation of the extract. The highest antioxidant activity was shown by cinnamon extract, followed by ginger, nutmeg and turmeric, while cardamom turned out to be the least free radical scavenger.
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Cardamom (Elettaria cardamomum) fruits or capsules are rich in bioactive phytochemicals with beneficial health impacts. Very few studies reported the chemistry and functionality of Elettaria cardamomum lipids, fixed oil, and cold pressed cardamom oil (CPCO). This work characterized CPCO for its lipid classes, fatty acids, phytosterols, tocols, total phenolics, antiradical potential (toward galvinoxyl and DPPH· radicals), antioxidative effects, and antimicrobial behavior (against foodborne bacteria and dermatophytic fungi). Neutral lipids were detected at the highest amount (ca. 96.6%), followed by glycolipids (ca. 2%) and phospholipids (ca. 1.3%). Oleic (C18:1, 43.7%), palmitic (C16:0, 21.6%), and linoleic (C18:2, 17.6%) were the major fatty acids in CPCO. The levels of monounsaturated fatty acids (MUFA), saturated fatty acids (SFA), and polyunsaturated fatty acids (PUFA) were 47%, 32%, and 21%, respectively. CPCO contained large amounts of unsaponifiables (16.4 g/kg). The total content of phytosterols was 222 mg/100 g oil, wherein β-sitosterol was the main compound, followed by sitostanol, campesterol, stigmasterol, Δ5-avenasterol, and citrostadienol. The total content of tocols was 2.38 mg/100 g of oil, and the contents (mg/100 g oil) of α-, β-, γ-, and δ-tocopherols in CPCO were 1.25, 0.08, 0.58, and 0.28, respectively. Besides, CPCO contained high amounts of total phenolics (3.9 mg GAE/g oil). CPCO exhibited better antiradical traits than extra virgin olive oil. The induction time (IT) recorded for sunflower oil (SFO) and CPCO blend (9:1, v/v) was 405 min, while the IT for blend) 8:2, v/v) was 532 min. Besides, CPCO showed broad antimicrobial effects against foodborne pathogens (Salmonella enteritidis, Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli) and dermatophytic fungi (Trichophyton mentagrophytes and Trichophyton rubrum). It could be concluded that CPCO is a good source of lipid-soluble bioactives, making it a unique raw material for novel food, cosmetic, and pharmaceutical products.
Background & aims Cardamom known as “queen of spice” seems to be an anti-diabetic agent due to its poly phenolic content. Since, recent studies reported controversial results related to its effect on metabolic factors, present meta-analysis examined the effect of cardamom supplementation on glycemic indices and weight profile of randomized controlled clinical trials (RCTs). Methods A wide search was done on biomedical electronic databases including Scopus, PubMed, Cochrane, EMBASE and Iranian databases, for all relevant literature published up to May 2021. Our search strategy included: [HbA1C, Blood Sugar, glycemic index, glucose tolerance test, insulin, insulin resistance, insulin sensitivity, body weight, BMI, body composition, waist circumferences] added to searched queries based on scientific Mesh terms. The included papers required to be RCTs that reported the effect of cardamom on glycemic and weight indices. We excluded studies with: a) non-randomized or non-controlled trials, b) animal studies, c) not available full text articles d) duplicate citations and e) not available full text articles. The risk of bias was assessed based on the Cochrane Risk of Bias tool. The effects of cardamom supplementation were assessed using standardized mean difference (SMD) statistics. The SMD of metabolic risk factors were pooled together using random effect meta-analysis method. Results Totally, six publications enrolling 410 participants was included in present meta-analysis. Daily 3 g supplementation of cardamom from 8 weeks to 3 months showed no significant effect on BMI (WMD: 0.07; 95% CI: [-0.12, 0.27]; P:0.5), weight (WMD: 0.01; 95% CI: [-0.22, 0.21]; P:0.95) and WC (WMD: 0.09; 95% CI: [-0.34, 0.17]; P:0.63), FBS (WMD: 0.10; 95% CI: [ −0.32, 0.12]; P:0.37), insulin (WMD: 0.83; 95% CI: [-2.07, 0.40]; P:0.19) and QUICKI (WMD: 1.14; 95% CI: [-1.11, 3.39]; P:0.32). However, significant effect occurred on HOMA-IR (WMD: 0.40; 95% CI: [-0.65, −0.15]; P:0.00), and HbA1C (WMD: 0.48; 95% CI: [-0.80, −0.16]; P:0.00). Conclusion Final findings suggest ameliorative effect of cardamom on metabolism of glucose.
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Natural products are a great wellspring of biodiversity for finding novel antivirals, exposing new interactions between structure and operation and creating successful defensive or remedial methodologies against viral diseases. The members of Zingiberaceae traditional plant and herbal products have robust anti-viral action, and their findings will further lead to the production of derivatives and therapeutic. Additionally, it highlights the insight of utilizing these phytoextracts or their constituent compounds as an emergency prophylactic medicine during the pandemic or endemic situations for novel viruses. In this connection, this review investigates the potential candidates of the Zingiberaceae family, consisting of bioactive phytocompounds with proven antiviral efficacy against enveloped viruses. The present study was based on published antiviral efficacy of Curcuma longa, Zingiber officinale, Kaempferia parviflora, Aframomum melegueta Elettaria cardamomum, Alpina Sps (belongs to the Zingiberaceae family) towards the enveloped viruses. The relevant data was searched in Scopus", "Scifinder", "Springer", "Pubmed", "Google scholar" "Wiley", "Web of Science", "Cochrane "Library", "Embase", Dissertations, theses, books, and technical reports. Meticulously articles were screened with the subject relevancy and categorized for their ethnopharmacological significance with in-depth analysis. We have comprehensively elucidated the antiviral potency of phytoextracts, major composition, key compounds, mode of action, molecular evidence, immunological relevance, and potential bioactive phytocompounds of these five species belonging to the Zingiberaceae family. Conveniently, these phytoextracts exhibited multimode activity in combating the dreadful enveloped viruses.
Introduction: Shwasa is said as Shigrapranahara Roga. It occurs as the main disease and also a symptom in various diseases. Shwasakruchrata is a common symptom that occurs in Hrudroga. Acharya Charaka mentioned the unique classification of drugs based on their action. Shwasahara Dashemani is one among them. It is containing 10 herbal drugs which are specially indicated in Shwasa Roga. Hence to evaluate the efficacy of Shwasahara Dashemani in Lakshana Roopi Shwasa in L.V.F (Cardiac Asthma) has taken for the study. Aim and Objective: The objective is to assess the efficacy of Shwasahara Dashemani in L.V.F with dyspnea (Cardiac Asthma). Method: The present study is a controlled comparative, open-label, clinical trial with pre and post-test design. A total of 40 subjects of a diagnosed case of L.V.F with dyspnea (Cardiac Asthma) were selected by using a simple random sampling method. Control group subjects were intervened with standard treatment of L.V.F and intervention group subjects were intervened with standard treatment of L.V.F along with Shwasahara Dashemani Ghana Vati, for the duration of 30 days. Its efficacy was assessed before treatment (0th day) and after treatment (31st day) by using BDI (Baseline Dyspnea Index Scale). Results: The P-value of dyspnea of the control group is 1.000 and the P-value of dyspnea of the intervention group is 0.105. This shows that the results of both groups are statistically not significant. But as compared to the control group, the intervention group is clinically significant because after the intervention 35% of subjects had shown improvement in the intervention group. Conclusion: As compared to the control group, in the intervention group Shwasahara Dashemani Ghanavati is clinically significant in relieving cardiac asthma when used with standard treatment of L.V.F. Keyword: Shwasahara Dashemani. Cardiac Asthma, L.V.F, Dyspnea
Essential oil of Elettaria cardamomum (Green cardamom) is effective in the treatment of various disease conditions. Globally, Guatemala is the leading producer of green cardamom fruits. Green-cardamom fruits from Guatemala were purchased from a Saudi Arabian market. The Guatemala cardamom essential oil (GCEO) was extracted using hydro-distillation method, and analyzed using gaschromatography/ mass-spectrometry (GC-MS). The antioxidant and anti-inflammatory activities were studied using 2,2-diphenyl-1-picrylhydrazyl-hydrate, ferric-chloride, bovine serum-albumin and proteinase inhibitory assays. GC-MS results confirmed the presence of α- terpinyl acetate and 1,8-cineole as major components. The antioxidant and anti-inflammatory activities of GCEO were found to be significant compared with those of standard ascorbic acid and ibuprofen, respectively. The molecular-docking study revealed the considerable binding potential of α-terpinyl acetate and 1,8-cineole with human-peroxiredoxin-5, tyrosine-kinases and Human-5-LOX receptors. The in-silico activity prediction analysis confirmed the antioxidant and anti-inflammatory potential, whereas the pharmacokinetics confirmed the safety of most of the GCEO compounds.
This study describes the antidiarrheal, antisecretory, and bronchodilatory activities of Hypericum perforatum Linn. (Hypericaceae), commonly known as St. John’s wort, to justify its traditional use in the hyperactivity of the gastrointestinal and respiratory systems. The crude extract of Hypericum perforatum (Hp.Cr) at a dose of 500 mg/kg caused 20% protection against castor oil-induced diarrhea in mice and 60% at 1000 mg/kg (p < 0.05 vs. saline). Hp.Cr at 300 and 1000 mg/kg reduced the castor oil-induced fluid accumulation in mice to 107.0 ± 3.3 g (p < 0.01) and 84.0 ± 4.2 g (p < 0.001) respectively, whereas in the castor oil-treated group, it was 126.9 ± 3.9 g. When tested against carbachol (CCh)-mediated bronchoconstriction in rats under anesthesia, Hp.Cr dose-dependently (3– 30 mg/kg) suppressed the CCh (1 μmol/kg)-induced increase in the inspiratory pressure. Thus this study rationalizes the Hypericum perforatum usefulness in overactive gut and airways disorders, such as diarrhea and asthma.
A chemical investigation based on H-1 NMR and MS studies revealed that the nonsaponifiable lipid fraction of cardamon consisted mainly of waxes and sterols. The waxes identified were n-alkanes (C21, C23, C25, C27, C29, C31, and C33) and n-alkenes (C21, C23, C25, C27, C29, C31, and C33). In the sterol fraction beta-sitostenone and gamma-sitosterol are newly reported. Phytol and traces of eugenyl acetate were also identified in cardamon for the first time.
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This study describes the gut, airways and cardiovascular modulatory activities of Zanthoxylum armatum DC. (Rutaceae) to rationalize some of its medicinal uses. The crude extract of Zanthoxylum armatum (Za.Cr) caused concentration-dependent relaxation of spontaneous and high K(+) (80 mM)-induced contractions in isolated rabbit jejunum, being more effective against K(+) and suggestive of Ca(++) antagonist effect, which was confirmed when pretreatment of the tissues with Za.Cr shifted Ca(++) concentration-response curves to the right, like that caused by verapamil. Za.Cr inhibited the castor-oil-induced diarrhea in mice at 300-1000 mg/kg. In rabbit tracheal preparations, Za.Cr relaxed the carbachol (1 microM) and high K(+)-induced contractions, in a pattern similar to that of verapamil. In isolated rabbit aortic rings, Za.Cr exhibited vasodilator effect against phenylephrine (1 microM) and K(+)-induced contractions. When tested in guinea pig atria, Za.Cr caused inhibition of both atrial force and rate of spontaneous contractions, like that caused by verapamil. These results indicate that Zanthoxylum armatum exhibits spasmolytic effects, mediated possibly through Ca(++) antagonist mechanism, which provides pharmacological base for its medicinal use in the gastrointestinal, respiratory and cardiovascular disorders.