To the Editor.—
May I call the attention of your readers to an uncommon side effect of methysergide, which is used in the prophylaxis of migraine and related headaches? A woman, aged 30, subject to frequent migraine attacks, was given methysergide, 2 mg twice daily. After two months she began losing scalp hair, although the migraine attacks remained in abeyance. Methysergide dosage was reduced ... [Show full abstract] to 2 mg daily. On this regimen, she had a few headaches, but hair loss continued, requiring a wig. After one month, methysergide therapy was discontinued and hair loss was reversed. This is a highly uncommon side effect of methysergide and has been reported only rarely. The hair loss may be self-limiting, despite the use of the drug. Spontaneous hair loss in patients with migraine or other disorders is also reported, but in this case seems unlikely.