To evaluate safety grade of road dangerous goods transportation enterprises, this paper presents five evaluation indices. In practical engineering, the indices were defined, and their calculating methods and grade values were given. According to the basic principles of subjective and objective weighting methods, an evaluation model is built up by means of a combinational evaluation method based on multi-objective programming, and an example is given to validate the practicability of it. The results show that the model can more accurately work out the safety grade of transportation enterprises than traditional evaluation methods and thus can perfectly reflect the comprehensive level of enterprises safety management.