Article

Frontopolar activation during face-to-face conversation: An in situ study using near-infrared spectroscopy

Department of Psychiatry and Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Neuropsychologia (Impact Factor: 3.3). 10/2009; 48(2):441-7. DOI: 10.1016/j.neuropsychologia.2009.09.036
Source: PubMed

ABSTRACT

Near-infrared spectroscopy (NIRS) is a functional brain imaging technique for monitoring brain activation in a natural setting using near-infrared light, and hence, is considered to have some advantages for studies of brain function during social interactions such as face-to-face conversation compared with functional magnetic resonance imaging and positron emission tomography, which have methodological constraints for studying brain mechanisms underlying social interactions: subjects have to lie down on a bed in a small gantry during examination. The purpose of this study was to validate the possible use of NIRS as a functional brain imaging technique for studying social interactions in a natural setting; therefore, we investigated frontal and temporal lobe activation during face-to-face conversation in healthy subjects in the sitting position. The frontal and superior temporal regions were activated during face-to-face conversation, with higher activity in the speaking segments than in the mute segments during conversation particularly in frontopolar NIRS channels. The magnitude of frontopolar activity negatively correlated with the cooperativeness score of the subjects assessed using the temperament and character inventory. These results demonstrated the successful monitoring of brain function during realistic social interactions using NIRS and interindividual differences in frontopolar activity during conversation in relation to the cooperativeness of an individual.

Download full-text

Full-text

Available from: Yuichi Takei, Apr 22, 2015
    • "Since fNIRS is relatively insensitive to motion artifacts, subjects can be examined in a natural sitting position, without any surrounding distraction (Takizawa et al., 2008). For example, fNIRS has been used in real-world situations (Dresler et al., 2009) such as face-to-face communication (Suda et al., 2010) and interpersonal cooperation (Cui et al., 2012). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Abstract: Social defeat (SD) hypothesis of schizophrenia posits that repeated experiences of SD may lead to sensitization of the mesolimbic dopaminergic system and precipitation of psychosis. Based on previous definitions adapted to human experimental paradigm, we prepared a computer simulation of SD to mimic this subjective experience. We measured prefrontal cortex (PFC) activity in subjects with schizophrenia and healthy controls during exposure to a single SD experience with functional near infrared spectroscopy. PFC activity declined in both groups. Compared with the control condition, SD exposure was associated with broader decline in left ventromedial, right medial and right lateral PFC activity in healthy controls (n=25), and a sharper decline in right ventrolateral PFC activity in subjects with schizophrenia (n=25). The activity in right ventrolateral PFC, was significantly lower in patients compared to controls. This may be due to deficiency in emotion regulation or self control or may be related to impairment in empathy in schizophrenia. Different brain activity during the SD experience in subjects with schizophrenia versus healthy controls may provide indirect evidence regarding SD hypothesis of schizophrenia.
    No preview · Article · Sep 2015 · Psychiatry Research: Neuroimaging
    • "Since fNIRS is relatively insensitive to motion artifacts, subjects can be examined in a natural sitting position, without any surrounding distraction (Takizawa et al., 2008). For example, fNIRS has been used in real-world situations (Dresler et al., 2009) such as face-to-face communication (Suda et al., 2010) and interpersonal cooperation (Cui et al., 2012). "
    [Show abstract] [Hide abstract]
    ABSTRACT: The social defeat (SD) hypothesis of schizophrenia posits that repeated experiences of SD may lead to sensitization of the mesolimbic dopaminergic system and to precipitation of psychosis. Based on previous definitions adapted to a human experimental paradigm, we prepared a computer simulation of SD to mimic this subjective experience. We measured prefrontal cortex (PFC) activity in subjects with schizophrenia and healthy controls during exposure to a single SD experience with functional near infrared spectroscopy. PFC activity declined in both groups. Compared with the control condition, SD exposure was associated with a broader decline in left ventromedial, right medial and right lateral PFC activity in healthy controls (n=25), and a sharper decline in right ventrolateral PFC activity in subjects with schizophrenia (n=25). The activity in the right ventrolateral PFC, was significantly lower in patients compared with controls. This may be due to a deficiency in emotion regulation or self-control, or it may be related to impaired empathy in schizophrenia. Different patterns of brain activity during the SD experience in subjects with schizophrenia versus healthy controls may provide indirect evidence regarding the SD hypothesis of schizophrenia. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
    No preview · Article · Jul 2015
  • Source
    • "However, in all of these studies, participants are, at best, detached observers of short, unrelated fragments of conversations, between people they don't know and don't care about. A number of recent studies (e.g., Dumas, Nadel et al., 2010; Dumas, Chavez, et al., 2012; Stephens, Silbert, & Hasson, 2010; Suda et al., 2010; for an overview see Babiloni & Astolfi, 2012) took issue with that, and started to investigate participants actively taking part in an interaction. Unfortunately, these studies had to restrict themselves to looking at very global measures of contiguity and synchronicity of processing; none of them takes into account what participants say to each other, when they say it, and how they say it. "

    Full-text · Chapter · Jun 2014
Show more