Outcomes Research in Cardiovascular Imaging: Report of a Workshop Sponsored by the National Heart, Lung, and Blood Institute

Division of Cardiovascular Medicine, Duke University Medical Center, Durham, NC, USA.
Circulation Cardiovascular Imaging (Impact Factor: 5.32). 07/2009; 2(4):339-48. DOI: 10.1161/CIRCIMAGING.108.123999
Source: PubMed


In July of 2008, the National Heart, Lung, and Blood Institute convened experts in noninvasive cardiovascular imaging, outcomes research, statistics, and clinical trials to develop recommendations for future randomized controlled trials of the use of imaging in: 1) screening the asymptomatic patient for coronary artery disease; 2) assessment of patients with stable angina; 3) identification of acute coronary syndromes in the emergency room; and 4) assessment of heart failure patients with chronic coronary artery disease with reduced left ventricular ejection fraction. This study highlights several possible trial designs for each clinical situation.

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Available from: Robert Bonow, Jun 15, 2014
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    • "The majority of clinical trials evaluating the performance of an imaging test have examined diagnostic accuracy. Linking an imaging test, subsequent therapy, and outcome can be difficult even within the context of a carefully conducted trial, owing to individual patient and provider behaviors [24]. Imaging tests can only capture a snapshot of cardiac structure or physiology, and provide an estimation of the natural progression of the disease of interest. "
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