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Observation on therapeutic effect of acupuncture for treatment of optic atrophy
Abstract
To search for an effective therapy for patients with optic atrophy to improve the visual function.
Thirty-eight cases (fifty-four affected eyes) of optic atrophy were treated with acupuncture, local points combined with points selected acording to syndrome differentiation were used, Jingming (BL 1), Cuanzhu (BL 2), and Fengchi (GB 20) were selected as main points, the therapeutic effects were evaluated after 2 courses of treatment, and variation of the indexes in patients such as vision, visual field and visual evoked potential were observed before and after treatment.
The total effective rate was 83.3%, the vision, visual acuity, and the amplitude of P100-wave were obviously improved after treatment (all P < 0.05).
Acupuncture can improve the visual function of patients with optic atrophy, and can be a effective therapy.
... The main points in the included studies were; Jingming (BL 1), Cuanzhu (BL 2), and Fengchi (GB 20). After two courses of treatment, the therapeutic effects were evaluated, and variation of the indexes in patients such as vision, visual field and visual evoked potential were observed before and after treatment and acupuncture showed a great treatment effect on patients in all included studies [31]. Another study containing 33 participants with optic atrophy treated with acupuncture on selected acupoints such as: Chengqi (ST 1), Shangjingming (Extra), Qiuhou (EX-HN 7) and Fengchi (GB 20), retaining needles after 30, once a day, for 14 days result shows that, the visual acuity was increased (P < 0.05), the MD value was decreased (P < 0.05), the thickness of nerve fiber layer on the upper temporal side of optic disc was thinner (P < 0.05), and the choroidal thickness of average, nasal side and lower temporal side of optic disc was increased (P < 0.05) as compared before treatment. ...
... [12][13][14][15][16][17][18][19][20] Several previous studies have reported that acupuncture may also benefit for patients with OPA. [21][22][23][24][25][26] However, its effectiveness for this disorder is still inconclusive. Thus, this study will comprehensively and systematically assess the effectiveness and safety of acupuncture for patients with OPA. ...
Background:
Optic atrophy (OPA) is a very tricky disorder. Presently, no effective management is available for this condition. Previous studies have reported that acupuncture may be effective for the treatment of OPA. However, its effectiveness is still inconclusive. Thus, this study will aim to assess the effectiveness and safety of acupuncture for OPA.
Methods:
A comprehensive literature search for relevant studies will be performed from the databases of PUMBED, EMBASE, CINAHI, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, Cochrane Library, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, and other literature sources from inception up to the present. No language limitations will be applied to all literature searches. We will consider all randomized controlled trials (RCTs) and case-controlled trials (CCTs) for assessing the effectiveness and safety of acupuncture for OPA. The primary outcomes include the rates of vision improvement and visual field improvement. The secondary outcomes consist of the increased visual field average sensitivity, pattern visual evoked potential (PVEP) amplitude, and shortened PVEP latency, as well as any expected and unexpected adverse reactions. Risk of bias assessment will be performed by Cochrane risk of bias for RCTs and Newcastle-Ottawa Scale for CCTs.
Results:
In this study, we will outline details of the aims and methods on the effectiveness and safety of acupuncture for the treatment of OPA.
Conclusion:
The results of this study will summarize the most current evidence of acupuncture for the treatment of patients with OPA.
Dissemination and ethics:
The results of this study are expected to be published on peer-reviewed journals. This is a literature-based study; therefore, no ethical approval is necessary.
Systematic review registration:
PROSPERO CRD42019135785.
... net. cn appear bleak, innovative approaches to the treatment of optic atrophy offer a ray of hope to these unfortunate patients [23,24] . Among others, a recent meta analysis of thirteen randomized controlled trials of acupuncture for treatment of optic atrophy showed promising results [25] . ...
AIM: To describe the aetiology and clinical profile of non-glaucomatous optic atrophy in a tertiary hospital in Malaysia. METHODS: A retrospective case series was conducted on patients diagnosed with non-glaucomatous optic atrophy who presented to the Eye Clinic of Hospital Universiti Sains Malaysia from 2007 until 2011 with a minimum of one year follow-up. Medical records of these patients were reviewed and the findings compiled. RESULTS: Of the 100 patients who met the selection criteria, 56% had bilateral involvement. The chief presenting symptom was visual blurring (61%), followed by visual blurring with neurological symptoms (18%) and visual field constriction (9%). Most patients (63%) had a presenting visual acuity worse than 3/60 in the affected eye. The main aetiologies were space-occupying intracranial lesions (26%), congenital/hereditary diseases (13%), hydrocephalus (12%), trauma (12%), and vascular causes (12%). The majority of cases (67%) were managed conservatively. Regardless of aetiology, optic atrophy was associated with variable degrees of visual dysfunction. At the end of one year, 50% of the patients had some degree of visual impairment. CONCLUSION: The main aetiology of optic atrophy was space-occupying intracranial lesions, followed by congenital/hereditary, trauma and vascular problems. Visual or neurological symptoms usually preceded the diagnosis, and visual acuity was significantly affected by the disease. A high level of suspicion is required in order to make an early diagnosis of optic atrophy, as the main complaint of visual blurring is usually non-specific.
... net. cn appear bleak, innovative approaches to the treatment of optic atrophy offer a ray of hope to these unfortunate patients [23,24] . Among others, a recent meta analysis of thirteen randomized controlled trials of acupuncture for treatment of optic atrophy showed promising results [25] . ...
AIM:To describe the aetiology and clinical profile of non-glaucomatous optic atrophy in a tertiary hospital in Malaysia. 誗METHODS: A retrospective case series was conducted on patients diagnosed with non-glaucomatous optic atrophy who presented to the Eye Clinic of Hospital Universiti Sains Malaysia from 2007 until 2011 with a minimum of one year follow-up. Medical records of these patients were reviewed and the findings compiled. 誗 RESULTS: Of the 100 patients who met the selection criteria, 56% had bilateral involvement. The chief presenting symptom was visual blurring (61%) , followed by visual blurring with neurological symptoms (18%) and visual field constriction (9%). Most patients (63%) had a presenting visual acuity worse than 3 / 60 in the affected eye. The main aetiologies were space-occupying intracranial lesions (26%) , congenital / hereditary diseases (13%) , hydrocephalus (12%) , trauma (12%) , and vascular causes (12%). The majority of cases (67%) were managed conservatively. Regardless of aetiology, optic atrophy was associated with variable degrees of visual dysfunction. At the end of one year, 50% of the patients had some degree of visual impairment. 誗CONCLUSION: The main aetiology of optic atrophy was space-occupying intracranial lesions, followed by congenital / hereditary, trauma and vascular problems. Visual or neurological symptoms usually preceded the diagnosis, and visual acuity was significantly affected by the disease. A high level of suspicion is required in order to make an early diagnosis of optic atrophy, as the main complaint of visual blurring is usually non-specific.
... Acupuncture has been widely used for ophthalmological diseases. Recently, studies on dry eye, glaucoma, optic nerve atrophy and other disorders have actively attempted to assess the efficacy and safety of acupuncture (Law & Li 2007;Liu et al. 2009;Lee et al. 2010). To show the specific effect of acupuncture for dry eye, randomized controlled trials (RCTs) adopting sham control groups are necessary. ...
To evaluate the efficacy and safety of acupuncture for ocular symptoms, tear film stability and tear secretion in dry eye patients.
This is a randomized, patient-assessor blinded, sham acupuncture controlled trial. Forty-two participants with defined moderate to severe dry eye underwent acupuncture treatment three times a week for 3 weeks. Seventeen standard points (GV23; bilateral BL2, GB14, TE23, Ex1, ST1 and GB20; and unilateral SP3, LU9, LU10 and HT8 on the left for men and right for women) with 'de qi' manipulation for the verum acupuncture group and seventeen sham points of shallow penetration without other manipulation for the sham group were applied during the acupuncture treatment. Differences were measured using the ocular surface disease index (OSDI), the visual analogue scale (VAS) of ocular discomfort, the tear film break-up time (BUT) and the Schimer I test with anaesthesia. In addition, adverse events were recorded.
There were no statistically significant differences between results on the OSDI, VAS, BUT or Schimer I tests from baseline between the verum and sham acupuncture groups. However, results from the within-group analysis showed that the OSDI and VAS in both groups and the BUT in the verum acupuncture group were significantly improved after 3 weeks of treatment. No adverse events were reported during this trial.
Both types of acupuncture improved signs and symptoms in dry-eye patients after a 4-week treatment. However, verum acupuncture did not result in better outcomes than sham acupuncture.
Acupuncture is a treatment option for dry eye syndrome (DES), but its efficacy remains still controversial. We assessed the effectiveness of this treatment for typical DES without specific aetiologies. Eight databases up through June 2018 were searched for randomized clinical trials (RCTs) comparing treatments of acupuncture with artificial tears. The risk of bias was assessed using Cochrane criteria, and a random effects model was used for meta‐analyses on tear‐film breakup time (BUT), Schirmer test, corneal fluorescein staining (CFS), ocular surface disease index, visual analogue scale and score of symptoms (SOS). Subgroup and sensitivity analyses were conducted to explore the heterogeneity, and publication bias was assessed by funnel plot using Egger’s test. Twenty‐one RCTs in 19 studies (n = 1542 eyes) met our eligible criteria. The results demonstrated the superiority of acupuncture in improving the symptoms of BUT, Schirmer test, CFS and SOS, compared to artificial tears acting alone. The BUT and Schirmer test were also more improved in acupuncture combination with artificial tears than artificial tears alone. Further subgroup analyses suggest that acupuncture applied at 2.0–3.0 times per week for 21–30 days may be optimal for treating typical DES. This provides useful information for guiding acupuncture in the clinical trials.
Objective:
To assess the effectiveness of acupuncture for the treatment of functional constipation
(FC).
Methods:
The literature was searched for randomized controlled trials (RCTs) comparing acupuncture
with medical treatment; no medical treatment, placebo acupuncture, and sham acupuncture in patients
with FC were searched. Data were extracted by two independent reviewers using standard data
extraction forms. Risk of bias for each RCT was assessed using a modified Oxford 5-point quality
scale. Data were pooled according to intervention and treatment course. Parameters evaluated included
effectiveness/invalidity, Cleveland Clinic score (CCS), colon transit time (CTT) and adverse effects.
Results:
Nineteen studies involving 1679 participants were eligible for inclusion; of these studies,
16 were published in Chinese and three in English. Risks of bias were high. Acupuncture was significantly
superior to medication therapy in short-term (effectiveness/invalidity, P = 0.0009; CCS, P = 0.02)
and long-term (effectiveness/invalidity, P = 0.004; CCS, P = 0.04; CCT, P < 0.0001) effectiveness. A
short treatment course of less than 15 days was sufficient. The likelihood of adverse effects was significantly
lower for acupuncture than for medication therapy (P = 0.002).
Conclusion:
Compared with medication, acupuncture was more effective and had a lower adverse
effect rate in the treatment of FC. A short treatment course of two weeks was sufficient for a
good effect. However, the poor quality of the included trials indicates the need for well-designed
RCTs, including adequate sample size and a reasonable placebo control, to assess the effectiveness of
acupuncture for FC.
Objective : The endpoint of this trial is to verify therapeutical availability of conventional western eyedrops combined with acupuncture treatment by means of BUT(tear film break-up time), Schirmer`s test, which have been considered to be typical methods for diagnosing dry eye syndrome. Methods : The subjects of this trial included the outpatients who had been diagnosed with dry eye syndrome in Pusan national university hospital and underwent acupuncture treatment from March 2011 to April 2011. They received acupuncture treatment once a week, three times while constantly using Restasis or artificial tears. We collated and analyzed the outcome data of Schirmer`s test and BUT conducted at the beginning of this trial and three times more after each acupuncture treatments. Acupoints, such as, Chanjuk(BL2), Eoryo, Sajukgong(TE23), Taeyang, Sabaek(ST2), limited around both eyes were selected based on their clinical effects referring to medical books. Results : 1. From BUT test results, Restasis and acupuncture combined group showed statistically significant difference, however, artificial tears and acupuncture combined group showed difference only between before and after the treatment, which is not statistically significant. 2. From Schirmer`s test results, Restasis and acupuncture combined group showed statistically significant difference, however, artificial tears and acupuncture combined group showed difference only between before and after the treatment, which is not statistically significant. 3. The average duration of treatment was statistically 16.3 days for Restasis and acupuncture combined group. Conclusions : Combination of acupuncture and Restasis for dry eye syndrome can shorten the duration of treatment. Therefore, clinical benefit is expected to be worth.
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