Obesity and Osteoarthritis: Is Leptin the Link?

Washington University School of Medicine, St. Louis, Missouri.
Arthritis & Rheumatology (Impact Factor: 7.76). 10/2009; 60(10):2858-60. DOI: 10.1002/art.24862
Source: PubMed

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    • "The current study showed a significant correlation between serum leptin and BMI. Revising literature, serum leptin was elevated in obese persons and correlated with the percent of body fat [13] [14] [22], also leptin concentration decreased after weight loss [22]. High serum and synovial leptin in obese patients with OA were thought to control local inflammatory processes [23]. "
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    ABSTRACT: The aim of the present work was to correlate between serum level of leptin, matrix metalloproteinase-13 (MMP13), interleukin-1β (IL1β), tumour necrosis factor (TNF-α), nitric oxide (NO) and functional impact in obese patients with knee osteoarthritis (KOA).
    Full-text · Article · Jun 2015 · Egyptian Rheumatologist
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    • "In humans, obesity is one of the major risk factors for developing OA, and recent studies indicate that, next to increased body weight and thus increased mechanical joint load, the adipose tissue itself may also induce or exacerbate OA, by excreting pro-inflammatory cytokines such as leptin (Otero et al. 2005; Gabay et al. 2008; Sandell 2009; Yusuf et al. 2010). However, if this will hold for TTD mice as well will necessitate extensive further analyses. "
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    ABSTRACT: The increasing average age in developed societies is paralleled by an increase in the prevalence of many age-related diseases such as osteoarthritis (OA), which is characterized by deformation of the joint due to cartilage damage and increased turnover of subchondral bone. Consequently, deficiency in DNA repair, often associated with premature aging, may lead to increased pathology of these two tissues. To examine this possibility, we analyzed the bone and cartilage phenotype of male and female knee joints derived from 52- to 104-week-old WT C57Bl/6 and trichothiodystrophy (TTD) mice, who carry a defect in the nucleotide excision repair pathway and display many features of premature aging. Using micro-CT, we found bone loss in all groups of 104-week-old compared to 52-week-old mice. Cartilage damage was mild to moderate in all mice. Surprisingly, female TTD mice had less cartilage damage, proteoglycan depletion, and osteophytosis compared to WT controls. OA severity in males did not significantly differ between genotypes, although TTD males had less osteophytosis. These results indicate that in premature aging TTD mice age-related changes in cartilage were not more severe compared to WT mice, in striking contrast with bone and many other tissues. This segmental aging character may be explained by a difference in vasculature and thereby oxygen load in cartilage and bone. Alternatively, a difference in impact of an anti-aging response, previously found to be triggered by accumulation of DNA damage, might help explain why female mice were protected from cartilage damage. These findings underline the exceptional segmental nature of progeroid conditions and provide an explanation for pro- and anti-aging features occurring in the same individual.
    Full-text · Article · Sep 2011 · Age
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    • "The present study confirmed that the serum leptin concentration was significantly correlated with the body weight and total fat mass in postmenopausal women with knee OA. These positive findings are consistent with the well-known fact that the serum leptin concentration is closely correlated with fat mass and decreases after weight loss [20]. OA is well known to be strongly correlated with a high BMI [20]. "
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    ABSTRACT: The objective of the present study was to identify factors correlated with the serum leptin concentration in women with knee OA. Fifty postmenopausal Japanese women with knee OA (age: 50-88 years) were recruited in our outpatient clinic. Plain radiographs of the knee were taken, and urine and blood samples were collected. Dual-energy X-ray absorptiometry (DXA) scanning was performed for the whole body and lumbar spine, and factors correlated with the serum leptin concentration were identified. A simple linear regression analysis showed that body weight, body mass index, whole-body bone mineral density (BMD), total fat mass, and total fat percentage, but not age, height, lumbar spine BMD, lean body mass, serum and urinary bone turnover markers, or the radiographic grade of knee OA, were significantly correlated with the serum leptin concentration. A multiple regression analysis showed that among these factors, only body weight and total fat mass exhibited a significant positive correlation with the serum leptin concentration. These results suggest that the serum leptin concentration might be related to increases in body weight and total fat mass, but not to BMD or bone turnover markers, in postmenopausal women with OA.
    Full-text · Article · Jan 2011
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