Difficulties in diagnosis of hemophagocytic lymphohistiocytosis: Case report

Dicle Medical Journal 01/2009;
Source: DOAJ


In 1991, diagnostic guidelines for hemophagocytic lymphohistiocytosis were presented by the Histiocyte Society; however, a number of patients may develop one or more of the diagnostic criteria late during the course of the disease. With these concerns in mind, the diagnostic guidelines have been revised at 2004. Delay in diagnosis may result in high morbidity and mortality. If we don’t verify the patient has a genetically disease or a familial form of hemophagocytic lymphohistiocytosis, and if the disease is severe, persistent, or recurrent, we have to start specific therapy for hemophagocytic lymphohistiocytosis. Here, we report the difficulties in diagnosis and treatment in a case with an atypical and insidious course in whom all criteria are not fulfilled at the beginning, and although the corticosteroid usage for suspicious underlying disease made the diagnosis conflict, and delayed criteria for hemophagocytic lymphohistiocytosis.

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Available from: Fatih Azik, Feb 25, 2014
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