Article

Value and Limitations of Existing Scores for the Assessment of Cardiovascular Risk. A Review for Clinicians

Cardiology Department, Adelaide Meath Hospital, Tallaght, Dublin, Ireland.
Journal of the American College of Cardiology (Impact Factor: 16.5). 09/2009; 54(14):1209-27. DOI: 10.1016/j.jacc.2009.07.020
Source: PubMed

ABSTRACT

Atherosclerotic cardiovascular diseases (CVDs) are the biggest causes of death worldwide. In most people, CVD is the product of a number of causal risk factors. Several seemingly modest risk factors may, in combination, result in a much higher risk than an impressively raised single factor. For this reason, risk estimation systems have been developed to assist clinicians to assess the effects of risk factor combinations in planning management strategies. In this article, the performances of the major risk estimation systems are reviewed. Most perform usably well in populations that are similar to the one used to derive the system, and in other populations if calibrated to allow for different CVD mortality rates and different risk factor distributions. The effect of adding "new" risk factors to age, sex, smoking, lipid status, and blood pressure is usually small, but may help to appropriately reclassify some of those patients who are close to a treatment threshold to a more correct "treat/do not treat" category. Risk estimation in the young and old needs more research. Quantification of the hoped-for benefits of the multiple risk estimation approach in terms of improved outcomes is still needed. But, it is likely that the widespread use of such an approach will help to address the issues of both undertreatment and overtreatment.

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Available from: Marie Therese Cooney, Mar 01, 2014
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    • "org/10.1016/j.dib.2016.01.002i As published scoring systems estimate 10-year risk, risk estimates were recalibrated for 7 years follow up to allow for comparison within the observed follow-up period [3] [4] [5] [6]. Recalibrated risk categories were as following: Low risk o5.25% and high-risk Z5.25%. "
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