This paper highlights the potential of key themes in Catholic Social Teaching (CST), when applied to business, to address the eradication of poverty. The themes selected are human dignity; solidarity; rights and responsibilities; and the spirit of enterprise. After summarizing each theme, the authors articulate each one in terms of a type of 'capital' (factor of production). They also present case studies that illustrate how responsible corporations can tackle poverty simply by executing their core business, rather than by adopting CSR projects. The authors conclude that CST provides a rich resource for reflection and action on the role of business in poverty alleviation. Its key insight is that poverty can best be overcome through enterprise in the global economy – 'entering the circle of exchange' (Centesimus annus). In the light of such teaching,, the Catholic church could play a crucial role in creating the moral and spiritual ethos in which pro-poor business can flourish, thereby helping to make poverty history.