The results of adjuvant radiotherapy in endometrial carcinoma

ArticleinGynecological Endocrinology 26(4):240-5 · September 2009with2 Reads
Impact Factor: 1.33 · DOI: 10.1080/09513590903225341 · Source: PubMed

    Abstract

    To examine the clinical characteristics and treatment outcomes in patients with endometrial cancer receiving adjuvant radiotherapy.
    A total of 157 patients who received postoperative radiotherapy (RT) between 1999 and 2008 were evaluated, retrospectively. The mean age was 59 years (34-82). All patients received RT following surgery. Stage distribution was as follows: 92 patients (59%) stage I, 21 patients (13%) stage II, and 44 patients (28%) stage III.
    Overall survival rate was 95% at 2 years and 84% at 5 years. By the end of follow up, 135 patients (86%) were disease-free, and 4 (2%) were alive with disease. Univariate and multivariate analyses identified stage, grade, and serosal involvement as significant predictors for overall survival.
    The results of our study suggests that early stage, low-grade endometrial cancer with no serosal involvement is associated with a better survival and adjuvant radiotherapy is a well tolerated and effective therapeutic option.