The extracellular matrix: At the center of it all

Texas A&M Health Science Center College of Medicine, Division of Molecular Cardiology, 1901 South 1st Street, Building 205, Room 1R24, Temple, TX 76504, USA.
Journal of Molecular and Cellular Cardiology (Impact Factor: 4.66). 09/2009; 48(3):474-82. DOI: 10.1016/j.yjmcc.2009.08.024
Source: PubMed


The extracellular matrix is not only a scaffold that provides support for cells, but it is also involved in cell-cell interactions, proliferation and migration. The intricate relationships among the cellular and acellular components of the heart drive proper heart development, homeostasis and recovery following pathological injury. Cardiac myocytes, fibroblasts and endothelial cells differentially express and respond to particular extracellular matrix factors that contribute to cell communication and overall cardiac function. In addition, turnover and synthesis of ECM components play an important role in cardiac function. Therefore, a better understanding of these factors and their regulation would lend insight into cardiac development and pathology, and would open doors to novel targeted pharmacologic therapies. This review highlights the importance of contributions of particular cardiac cell populations and extracellular matrix factors that are critical to the development and regulation of heart function.

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Available from: Indroneal Banerjee
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    • "Specific cell–substrate or cell to cell interactions involve components of the extracellular matrix and cell adhesion molecules as integrins, cadherins, and selectins (Bowells Sthepanie et al., 2010; Juliano, 2002; Kleinmann et al., 2003). Otherwise, unspecific adhesion mechanisms are rather resulting of the interaction due to the physico-chemical properties of the substrate such as surface hydrophobicity, surface charge, and surface functional groups (Lee et al., 2005). "
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