Synthesis of a Neonicotinoid Pesticide Derivative via Chemoenzymatic Dynamic Kinetic Resolution

ArticleinThe Journal of Organic Chemistry 74(19):7407-10 · October 2009with7 Reads
Impact Factor: 4.72 · DOI: 10.1021/jo9014276 · Source: PubMed

    Abstract

    Chemoenzymatic dynamic kinetic resolution (DKR) via combined ruthenium and enzyme catalysis was used in the key step of a synthesis of a neonicotinoid pesticide derivative (S)-3. The DKR was carried out under mild conditions with low catalyst loading. The method gives (S)-3 in high enantiomeric excess (98%).