Aurora A moonlights in neurite extension

ArticleinNature Cell Biology 11(9):1053-4 · October 2009with2 Reads
Impact Factor: 19.68 · DOI: 10.1038/ncb0909-1053 · Source: PubMed

    Abstract

    Aurora A, an integral mitotic kinase, is essential for microtubule dynamics of post-mitotic neurons. PKCzeta activates Aurora A, which in turn phosphorylates NDEL1 to promote neurite extension. This raises the possibility that Aurora A may also be involved in establishing cell polarity and axon/dendrite elaboration in young neurons.