Tumor-to-tumor Metastases to Follicular Variant of Papillary Thyroid Carcinoma: Histologic, Immunohistochemical, and Molecular Studies of Two Unusual Cases

ArticleinEndocrine Pathology 20(4):235-42 · September 2009with9 Reads
Impact Factor: 1.76 · DOI: 10.1007/s12022-009-9087-x · Source: PubMed


    Tumor-to-tumor metastasis in thyroid neoplasms is exceedingly uncommon. Two unusual cases of breast carcinoma and renal cell carcinoma metastatic to follicular variant papillary carcinoma are reported. On histologic sections, the donor tumor cells infiltrated the substance of the recipient tumor and the angiolymphatic channels, but the bulk of metastatic tumor was confined within the thyroid carcinoma. Immunohistochemical stains as well as molecular studies confirmed the origin of both donor tumors, as well as the diagnosis of follicular variant of papillary carcinoma in the recipient tumors. Distinguishing between two such tumor populations may be difficult when the donor tumor cells morphologically resemble primary neoplasms of the recipient organ. A history of previous malignancy and ancillary studies can be helpful in making this distinction and rendering the correct diagnosis. A brief review of literature and discussion of tumor-to-tumor metastasis in thyroid neoplasms is also presented.