Inflammatory Biomarkers and Fatigue during Radiation Therapy for Breast and Prostate Cancer

Department of Psychology, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095-1563, USA.
Clinical Cancer Research (Impact Factor: 8.72). 09/2009; 15(17):5534-40. DOI: 10.1158/1078-0432.CCR-08-2584
Source: PubMed


Biomarkers of radiation-induced behavioral symptoms, such as fatigue, have not been identified. Studies linking inflammatory processes to fatigue in cancer survivors led us to test the hypothesis that activation of the proinflammatory cytokine network is associated with fatigue symptoms during radiation therapy for breast and prostate cancer.
Individuals with early-stage breast (n = 28) and prostate cancer (n = 20) completed questionnaires and provided blood samples for determination of serum levels of interleukin 1beta (IL-1beta) and IL-6 at assessments conducted before, during, and after a course of radiation therapy. Serum markers of proinflammatory cytokine activity, including IL-1 receptor antagonist and C-reactive protein, were examined in a subset of participants. Random coefficient models were used to evaluate the association between changes in cytokine levels and fatigue.
As expected, there was a significant increase in fatigue during radiation treatment. Changes in serum levels of inflammatory markers C-reactive protein and IL-1 receptor antagonist were positively associated with increases in fatigue symptoms (Ps < 0.05), although serum levels of IL-1beta and IL-6 were not associated with fatigue. These effects remained significant (Ps < 0.05) in analyses controlling for potential biobehavioral confounding factors, including age, body mass index, hormone therapy, depression, and sleep disturbance.
Results suggest that activation of the proinflammatory cytokine network and associated increases in downstream biomarkers of proinflammatory cytokine activity are associated with fatigue during radiation therapy for breast and prostate cancer.

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Available from: Najib Aziz, Mar 12, 2014
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    • "a ) , a marker of IL - 1b activity ( Arend et al . , 1998 ) ; and C reactive protein ( CRP ) , a marker of IL - 6 activity ( Dayer et al . , 2007 ) . All of these markers have been associated with cancer related fatigue in previous research ( Bower et al . , 2002 ; Collado - Hidalgo et al . , 2006 ; Orre et al . , 2009 ; Alexander et al . , 2009 ; Bower et al . , 2009 ) . In addition , we assessed IL - 6 based on earlier yoga trials showing effects on this cyto kine ( Pullen et al . , 2008 , 2010 ) . Plasma levels of IL - 1ra and sTNF - RII were determined by ELISA ( R&D Systems , Minneapolis , MN ) according to the manufacturer ' s protocols , with a lower limit of detection of 31 and 234 pg / ml , "
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