A new effective scaffold to facilitate peripheral nerve regeneration: Chitosan tube coated with maggot homogenate product

Department of Orthopedic Surgery, First Affiliated Hospital, Dalian Medical University, Dalian 116011, Liaoning Province, China.
Medical Hypotheses (Impact Factor: 1.07). 09/2009; 74(1):12-4. DOI: 10.1016/j.mehy.2009.07.053
Source: PubMed


Recent efforts in scientific research in the field of peripheral nerve regeneration have been directed towards the development of artificial nerve guides. Chitosan tubes applied as a biocompatible and biodegradable bilateral guide for nerve repair is a hot spot in research to date. In previous study, we have found the homogenate product from disinfected maggot larvae can promote wound nerve regeneration and neuropeptides release. Wound nerves belong to the peripheral nerve system. We thus hypothesize that maggot homogenate product use as an external layer outside the chitosan tube will be an effective therapy to facilitate peripheral nerve regeneration.

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    • "Using remittance spectroscopy to evaluate patients before and after maggot therapy, Wollina and colleagues [68] found that vascular perfusion and tissue oxygenation surrounding the wound actually increased following maggot therapy. Zhang and colleagues [69] are currently seeing evidence that maggot extracts may even stimulate the growth of neural tissue. Early clinical reports of maggot-induced wound healing were merely case studies or series; but beginning in the 1990's, controlled comparative trials of maggot therapy began to appear. "
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