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Clinical success of lysine in association with serumal and salivary presence of HSV-1 in patients with recurrent aphthous ulceration
Abstract and Figures
Objective: The aim of this study was to investigate the clinical effects of L-lysine monohydrochloride which is known to be a natural viral inhibitor based on a probable role of herpes simplex virus on recurrent aphthous ulcer (RAU) etiology. Method: Thirty patients were divided into placebo and lysine treatment groups. After the end of two months’ therapy, clinical changes of ulcers were recorded and the effectiveness of the study was measured by the success degrees given by the patients. Herpes simplex type-1 (HSV-1) presence was examined by ELISA in serumal samples and by real-time PCR technique in salivary samples of the patients. Results: The number and the recurrence of the ulcers decreased significantly in lysine group. Most patients in lysine group found the therapy more successful. The difference in HSV-1 IgG was statistically significant between the healthy and aphthous ulcer groups while the difference in HSV-1 DNA was not. Conclusion: The presence of HSV in saliva suggests a possible role in RAU etiology, and it seem to be worthwhile to attempt antiviral therapies for RAU treatment. [J Exp Integr Med 2011; 1(3.000): 191-196]
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