ChemInform Abstract: Diketopiperazine Alkaloids from a Deep Ocean Sediment Derived Fungus Penicillim sp

ArticleinCHEMICAL & PHARMACEUTICAL BULLETIN 57(8):873-6 · September 2009with16 Reads
Impact Factor: 1.16 · DOI: 10.1248/cpb.57.873 · Source: PubMed

Five new diketopiperazine alkaloids, brevicompanines D-H (3-7), together with two known analogs, allo-brevicompanine B (1) and fructigenine B (2), were isolated from a deep ocean sediment derived fungus Penicillium sp. Their structures were established by spectroscopic methods including 2D NMR and chiral HPLC analysis. Compounds 4 and 7 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in BV2 microglial cells.

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