Carcinoma within solitary ductal papilloma of the breast

ArticleinEuropean journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 36(4):384-6 · August 2009with21 Reads
Impact Factor: 3.01 · DOI: 10.1016/j.ejso.2009.07.001 · Source: PubMed

Solitary ductal papilloma of the breast, traditionally considered a benign disorder, was recently found to have malignant potential, especially when associated with atypical ductal hyperplasia. All patients diagnosed with solitary ductal papilloma at a tertiary medical center from 1994 to 2004 were identified by a database search. Background, clinical and pathological data were collected for those with a carcinoma within the papilloma, and their pathological specimens were revised. Of the 3849 breast biopsies performed in our medical center during the study period, 77 (2%) yielded a solitary ductal papilloma. In 12 cases (15.6% of all solitary ductal papillomas; 0.3% of all breast biopsies), a carcinoma was found within the papilloma. Ten were diagnosed as carcinoma in situ and 2 as microinvasive carcinoma. In the present series, the incidence of carcinoma within solitary ductal papilloma was 15.6%, indicating that solitary ductal papillomas have malignant potential. Carcinoma within solitary ductal papilloma of the breast was found in 15.6% of all papillomas. This seems to indicate a malignant potential of papillomas and the need for surgical excision.

  • [Show abstract] [Hide abstract] ABSTRACT: Intraductal papillomas often present as small, smooth masses, dilated ducts or microcalcifications at mammography and as smooth, hypoechoic masses at sonography. At magnetic resonance imaging (MRI), intraductal papillomas often present as small smooth masses, however, often with strong enhancement with type 2 or 3 time intensity curves. The result of the MR analysis is therefore not infrequently inconclusive in order to characterize the mass as benign or malignant. To characterize the appearance of intraductal papillomas of the breast at MRI, and determine whether the application of diagnostic rules described in literature could contribute to correctly classifying the lesions as benign. Twenty patients with histologically proven intraductal papillomas were included. Two radiologists independently reviewed the MR images of the breast. The BI-RADS(®) nomenclature was used to describe morphology and contrast-enhancement kinetics. Interobserver agreement in the interpretation of the MR images by the two investigators was performed. Kappa coefficient was calculated as index for the level of agreement. Subsequently, three sets of diagnostic rules, including the Göttinger score described by Fischer and the interpretation flowcharts according to Kinkel and to Tozaki were applied to characterize whether a biopsy should be recommended or not. All papillomas presented as masses on dynamic contrast-enhanced MRI. Only five papillomas showed a round, oval, or lobulated shape combined with smooth margins and continuous rise of the time intensity curve. Using the Göttingen score, biopsy would be recommended in 16 patients. Based on the interpretation flowcharts of Kinkel and of Tozaki, an additional 13 and 10 papillomas, respectively, were correctly classified as benign. Dilated ducts were visible in 10 patients. The interobserver agreement was good or excellent for all included variables. Including systematic analysis of breast MRI to the diagnostic protocol and interpreting the images according to predetermined diagnostic rules, most solitary intraductal papillomas of the breast may be correctly characterized as benign.
    Full-text · Article · Apr 2011 · Acta Radiologica
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  • [Show abstract] [Hide abstract] ABSTRACT: Objective: To approach the clinical situation, diagnosis, treatment, and prognosis of breast carcinoma associated with intraductal papilloma ( IP ) and intraductal papillomatosis ( IPS ). Methods: Thirty-five cases of breast carcinoma from IP and 54 cases of breast carcinoma from IPS were retrospectively studied. Results: All patients were examined by mammography and ultrasonography before they underwent surgery. There were 20 cases of ductal carcinoma in situ and 15 cases of invasive carcinoma associated with IP, and 42 cases of ductal carcinoma in situ and 12 cases of invasive carcinoma associated with IPS. They all received breast-conserving surgery or mastectomy with/without axillary lymph node dissection. Adjuvant chemotherapy and radiotherapy accounted for 45.71% and 59.26% in the IP and IPS groups, respectively. There was one case of positive axillary lymph nodes in the IP group and three cases of positive axillary lymph node in the IPS group. All these cases had only one positive lymph node. All patients were followed up 3-8 years post-operation. Chest wall recurrence was observed in only one case, which had positive margin. Conclusion: Breast carcinomas associated with IP and with IPS are rare and have good prognosis. Safe surgical procedures with clean margins are necessary, and sentinel lymph node dissection is recommended.
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  • [Show abstract] [Hide abstract] ABSTRACT: Solitary ductal papilloma of the breast, although considered a benign disorder has a potential association with carcinomas. We studied and analyzed the role of selective ductectomy (SD) for the diagnosis and treatment of intraductal lesions presenting with single duct discharge and ductography suggestive of intraductal (papillary) lesions. During a ten-year-period, files of patients presenting with single (or rarely dual) duct discharge were retrospectively reviewed. The examinations included mammography, ductography and ultrasonography and cytology of the fluid discharged from the duct in all patients. Patients treated with SD were considered further and their histological diagnosis and treatment were analyzed. The series included 100 patients. In 6 cases malignancy was found in the specimen consisting of four in situ and two invasive ductal carcinomas. These 6 patients had a second operation and this was followed by adjuvant treatment. Nine further patients had atypical ductal hyperplasia in or around papillomas and one patient had lobular neoplasia around her papilloma. In the present series, the incidence of carcinoma associated with the clinical suspicion of papillary lesions was 6%, and further 10% had low grade neoplastic proliferations resulting in the diagnosis of atypical papillomas or atypical ductal hyperplasia or lobular neoplasia around the papilloma, indicating that single duct discharge may be a symptom a malignancy, and that ductal papillomas have malignant potential. For such a low risk and grade of malignancy simple follow-up could be one option, but in some cases SD could be applied to relieve the patients from symptoms and establish a diagnosis.
    No preview · Article · Mar 2013 · Pathology & Oncology Research
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