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Radical scavenging activity and cytotoxicity of Euphorbia hirta L. growing in Egypt
Abstract
Cited By (since 1996):1, Export Date: 18 October 2014
... The results obtained suggest that the extracts of E. hirta had strong antioxidant potential. These results are similar to those of kandalkar et al. (2010); Basma et al. (2011);Bakr et al. (2012) who found that E. hirta possesses antioxidant activity. Some health disorders like mastitis which can affect all lactating mammals, occurs during the early of lactation generally the first month, seems to be related to oxidative stress. ...
Breastfeeding is widely recognized to have many health benefits for
both infants and mothers and in developing countries, women rely on
medicinal plants to increase breast milk production. Euphorbia hirta is
one of the medicinal plants used in Burkina Faso for the treatment of
lactation insufficiency. The purpose of this study was to investigate its
effect on milk production. Previous studies were achieved to identify
phytochemical compounds, to assess innocuity and antioxidant activity
of the plant. Oral acute and sub-acute toxicity were carried out as
described by Organization for Economic Cooperation and Development
(OECD) 2001 and 2008, respectively. Several methods including
Diphenylpicrylhydrazyl (DPPH), Ferric reducing power (FRAP), Lipid
peroxidation were used to evaluate antioxidant activity. The effect of
Euphorbia hirta on milk production was assess in lactating rats.
Preliminary phytochemical screening revealed the presence of steroids
and triterpenoids, tannins, flavonoids, coumarins, anthocyanosids,
reducing sugars. The plant exhibited strong antioxidant potential. Limit
test of 2000 mg/kg b.w. did not cause any mortality and no signs of
acute toxicity suggesting that the plant is practically non-toxic.
Concerning sub-acute toxicity, no mortality and no signs of toxicity
were observed in all the extract treated groups similarly to control
group. Haematological and biochemical parameters were not affected
by the extract, therefore the plant is safe for use when it is administered
orally. The extract treated rats produced higher milk than blank and
reference controls. The body weight gain of the pups was 2.40±0.08,
2.81±0.22 and 2.78±0.28 for blank, reference controls and extract
treated group, respectively. Euphorbia hirta contains several
phytochemical compounds which may stimulate milk production in
mammalian.
... The results obtained suggest that the extracts of E. hirta had strong antioxidant potential. These results are similar to those of kandalkar et al. (2010); Basma et al. (2011);Bakr et al. (2012) who found that E. hirta possesses antioxidant activity. Some health disorders like mastitis which can affect all lactating mammals, occurs during the early of lactation generally the first month, seems to be related to oxidative stress. ...
... Euphorbia hirta L. is used as a folk medicine in Taiwan. Its pharmacological properties include sedative, anxiolytic, analgesic, antipyretic [20], anti-anaphylactic [21], antidiarrheal [22], antibacterial [23,24], antifungal [25], radical scavenging activity [26], diuretic [27] effects, and suppression of the onset of acute allergic phase activities [28]. In addition, the anti-inflammatory effect of Euphorbia hirta L., via its active component β-amyrin (Figure 1), has been demonstrated in LPS-activated macrophages [29]. ...
The inflammatory reaction in large blood vessels involves up-regulation of vascular adhesion molecules such as endothelial cell selectin (E-selectin), soluble vascular cell adhesion molecule (sVCAM)-1, and soluble intercellular adhesion molecule (sICAM)-1. These vascular dysfunctions are associated with the development of atherosclerosis. β-Amyrin, an active component of Euphorbia hirta L., has potent anti-inflammatory effects. So far, its preventive effects against the expression of inflammatory mediator-induced adhesion molecules have not been investigated. Endothelial cells (SVEC4-10 cell line) were treated with 50% RAW conditioned media (i.e., normal SVEC4-10 culture media contains 50% of lipopolysaccharide-activated macrophage culture media) without or with β-amyrin (0.6 and 0.3 µM). The production levels of E-selectin, sICAM-1, and sVCAM-1 in the SVEC4-10 cells were measured with ELISA assay kits. Under the same treatment conditions, expression of endothelin (ET)-1 and endothelial type of NO synthase (eNOS) mRNA were analyzed by RT-PCR and agarose gel. With β-amyrin, the 50% RAW conditioned media-induced E-selectin, sICAM-1, and sVCAM-1 levels as well as ET-1 gene expression were all suppressed. β-Amyrin treatment also restored the 50% RAW conditioned media-suppressed eNOS mRNA expression. These data indicate that β-amyrin is potentially useful in preventing chronic inflammation-related vascular diseases.
Carica papaya L., Cynodon dactylon (L.) Pers, Euphorbia hirta L., Melia azedarach L., Psidium guajava L. belong to 5 different families, viz., Caricaceae, Gramineae (Poaceae), Euphorbiaceae, Meliaceae and Myrtaceae. The plant leaves contain a number of medicinally important compounds. In the present study, we evaluated the phytochemical analysis for the quantity of amino acids, α amylase, β- amylase, carbohydrate, glutamine, protein, proline, phenolic compounds and the presence of various secondary metabolites such as alkaloids, anthroquinone, catachol, flavonoids, phenols, saponins, steriods, triterpenoids, tannins. The antibacterial activity of the leaf extracts of Carica papaya, Cynodon dactylon, Euphorbia hirta, Melia azedarach and Psidium guajava against pathogenic bacteria like gram positive (Bacillus subtilis, Pseudomonas aeruginosa and Staphylococcus aureus) and gram negative (Escherichia coli and Klebsiella pneumoniae) bacteria by in vitro agar well diffusion method. The plants aqueous leaf extracts showed pronounced inhibition than chloroform leaf extracts. Leaf extracts showed more inhibitory action on Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae.